THE EFFECT OF MINOCYCLINE ON GENE EXPRESSION OF GABAA RECEPTOR IN HIPPOCAMPUS AND PIRIFORM BRAIN AREAS ON AMYGDALE KINDLING ACQUISITION IN RAT

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RAMSHINI HASAN; MOHAMMAD ZADEH MOHAMMAD; BEHESHTI NASR SEYED MEHDI

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Journal: Journal of Sabzevar University of Medical Sciences Year:2014 | Volume:21 | Issue:2 Page(s): 352-361

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Title

THE EFFECT OF MINOCYCLINE ON GENE EXPRESSION OF GABAA RECEPTOR IN HIPPOCAMPUS AND PIRIFORM BRAIN AREAS ON AMYGDALE KINDLING ACQUISITION IN RAT

Author(s)

RAMSHINI HASAN | MOHAMMAD ZADEH MOHAMMAD | BEHESHTI NASR SEYED MEHDI | Issue Writer Certificate

Keywords

EPILEPSYQ2

KINDLINGQ2

MINOCYCLINEQ2

GABAA RECEPTORQ2

Abstract

Introduction: MINOCYCLINE has anticonvulsant effects. Since some antiepileptic drugs increase the neurotransmitter GABA in the brain, the aim of this study is the effect of MINOCYCLINE on gene expression of GABAA RECEPTOR in hippocampus and piriform brain areas on amygdale KINDLING acquisition in rat.Methods: In this experimental study, three group (24 Wistar rats), after stereotaxic surgery and 1 week recovery period, received KINDLING stimulations (twice daily at 6 hours interval).Group 1 (n=8) did not receive daily KINDLING stimulations. Group 2 (n=8) received intraperitoneal saline (1ml/kg) and Group 3 (n=8) received intraperitoeneal MINOCYCLINE (25 mg/kg) 60 min before KINDLING stimulation and respectively. Two hours after the last stimulation, animals’ brains were removed and the changes of gene expression by γ2 subunit of GABAA RECEPTOR in the hippocampus and piriform cortex were measured and compared with the control group. Data was analyzed using one-way ANOVA and Tukey post hoc tests (P<0.05).Results: In Group 3 intraperitoneal administration of MINOCYCLINE for 10 days reduced cumulative ADD significantly reduced in comparison with the control group (Group 2) (P<0.001); also, it increased significantly the delay time of stage 4 (p<0.01) and stage 5 (p<0.001) of the seizures. In addition, the injection of MINOCYCLINE before KINDLING stimulations removed the electrical stimulation induced an increase in mRNA of γ2 subunit of GABAA RECEPTOR in hippocampus and piriform cortex of amygdale KINDLING.Conclusion: The results of this study showed that MINOCYCLINE administration before electrical stimulation acts as an anticonvulsant, and this effect occurs via reducing GABAA RECEPTORs.

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APA: Copy

RAMSHINI, HASAN, MOHAMMAD ZADEH, MOHAMMAD, & BEHESHTI NASR, SEYED MEHDI. (2014). THE EFFECT OF MINOCYCLINE ON GENE EXPRESSION OF GABA_A RECEPTOR IN HIPPOCAMPUS AND PIRIFORM BRAIN AREAS ON AMYGDALE KINDLING ACQUISITION IN RAT. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 21(2), 352-361. SID. https://sid.ir/paper/82400/en

Vancouver: Copy

RAMSHINI HASAN, MOHAMMAD ZADEH MOHAMMAD, BEHESHTI NASR SEYED MEHDI. THE EFFECT OF MINOCYCLINE ON GENE EXPRESSION OF GABA_A RECEPTOR IN HIPPOCAMPUS AND PIRIFORM BRAIN AREAS ON AMYGDALE KINDLING ACQUISITION IN RAT. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;21(2):352-361. Available from: https://sid.ir/paper/82400/en

IEEE: Copy

HASAN RAMSHINI, MOHAMMAD MOHAMMAD ZADEH, and SEYED MEHDI BEHESHTI NASR, “THE EFFECT OF MINOCYCLINE ON GENE EXPRESSION OF GABA_A RECEPTOR IN HIPPOCAMPUS AND PIRIFORM BRAIN AREAS ON AMYGDALE KINDLING ACQUISITION IN RAT,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. 2, pp. 352–361, 2014, [Online]. Available: https://sid.ir/paper/82400/en

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