CHANGES IN PRE-INFLAMMATORY CYTOKINES AND MARKERS OF VASCULAR INFLAMMATION AFTER REGULAR ENDURANCE TRAINING

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MOGHARNASI M.; GAEINI A.A.; SHEYKH ALESLAMI VATANI D.

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Journal: Zahedan Journal of Research in Medical Sciences Year:2008 | Volume:10 | Issue:2 Page(s): 125-135

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Title

CHANGES IN PRE-INFLAMMATORY CYTOKINES AND MARKERS OF VASCULAR INFLAMMATION AFTER REGULAR ENDURANCE TRAINING

Author(s)

MOGHARNASI M. | GAEINI A.A. | SHEYKH ALESLAMI VATANI D. | Issue Writer Certificate

Keywords

IL-1βQ3

TNF-αQ3

SICAM-1Q3

ENDURANCE TRAININGQ1

INFLAMMATORYQ2

ATHEROSCLEROSISQ3

Abstract

Background: Growing evidence indicates that pre-inflammatory cytokines and cellular adhesion molecules that increase vascular endothelial activity are more sensitive in anticipating cardiovascular diseases. These novel INFLAMMATORY markers may play an important role in pathogenesis of ATHEROSCLEROSIS. The purpose of this study was to determine the changes in preinflammatory cytokines and markers of vascular inflammation after regular ENDURANCE TRAININGin Wistar rats.Materials and Methods: In this experimental study, 24 male rats (3 months old) were kept ina controlled condition and were divided into two different control (n=12, weight=211Bgr) and experimental (n=12, weight=208±7gr) groups. The training program was performed 3 times a week for 12 weeks under certain duration and speed. The blood sampling was performed after 14 fasting hours in different stages and with the same conditions. Elisa trade kits were used to measure SICAM-1, TNF-a, and IL-1b. Resulting data were analyzed by dependent and independent t-tests (a =0. 05).Results: A significant increase was observed in IL-1b (p=0.045), TNF-a (p=0.047), and s1CAM-1(p=0.028) levels in control group, while a significant decrease in IL-1b (p=0.002), TNF-a (p=0.016), and SICAM-1 levels was shown in experimental group (p=0.000). Also, a significant difference was observed in comparison between control and experimental groups about IL-1b (p=0.039), TNF-a (p=0.028), and SICAM-1 (p=0.000).Conclusion: The results of this study showed that regular ENDURANCE TRAINING (V02max55-85%) reduces the amounts of INFLAMMATORY markers of cardiovascular diseases including SICAM-1, TNFa, and IL-1b. This training method can play an efficient role in declining the risk of ATHEROSCLEROSIS by lowering markers of vascular inflammation.

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APA: Copy

MOGHARNASI, M., GAEINI, A.A., & SHEYKH ALESLAMI VATANI, D.. (2008). CHANGES IN PRE-INFLAMMATORY CYTOKINES AND MARKERS OF VASCULAR INFLAMMATION AFTER REGULAR ENDURANCE TRAINING. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 10(2), 125-135. SID. https://sid.ir/paper/84486/en

Vancouver: Copy

MOGHARNASI M., GAEINI A.A., SHEYKH ALESLAMI VATANI D.. CHANGES IN PRE-INFLAMMATORY CYTOKINES AND MARKERS OF VASCULAR INFLAMMATION AFTER REGULAR ENDURANCE TRAINING. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2008;10(2):125-135. Available from: https://sid.ir/paper/84486/en

IEEE: Copy

M. MOGHARNASI, A.A. GAEINI, and D. SHEYKH ALESLAMI VATANI, “CHANGES IN PRE-INFLAMMATORY CYTOKINES AND MARKERS OF VASCULAR INFLAMMATION AFTER REGULAR ENDURANCE TRAINING,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 10, no. 2, pp. 125–135, 2008, [Online]. Available: https://sid.ir/paper/84486/en

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