EFFECT OF LORAZPAM ON THE ANATOMICAL DEVELOPMENT OF MORPHOGENESIS OF THE SECONDARY PALATE IN THE RAT EMBRYO

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FAGHANI M.; NADIA SHARIFI Z.; SALSABILI N.

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Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2003 | Volume:10 | Issue:36-37 Page(s): 21-26

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Title

EFFECT OF LORAZPAM ON THE ANATOMICAL DEVELOPMENT OF MORPHOGENESIS OF THE SECONDARY PALATE IN THE RAT EMBRYO

Author(s)

FAGHANI M. | NADIA SHARIFI Z. | SALSABILI N. | Issue Writer Certificate

Keywords

LARAZEPAMQ4

SECONDARY PALATEQ4

ANATOMICALQ4

Abstract

Lorazpam which is one of GABA argic A.B receptors of the Benzodiazepines compile group was studied in view of morphogenesis, histologically and histochemically with dosage of 2mg, 4mg /kg/day compared with control group. In this study, 350 rat embryos (Whistar) of 9 to 17 days of gestation were used. After fixation, they were sectioned serially and stained with Toluidine-blue, H+E, Trichromemasson's, Paraldehyde fushin, in order to find out histochemically the extracellular material exchange and cellular activity.The results: 1-During stage of 9-14 days of gestation no difference or malformation proved significant morphologically and histochemically between two groups of experiments and control group. 2-in stages of 14-17 days of embryo, specially in 4mg/kg/day experiments lorazpam administrated, significantly morphometric difference was observed in height(p<0/05), weight(p,0.01)with control group, whereas malformation of limbs specially in hands, joints, eyes, ears, and body formations were observed in all embryo. 3-In histological & histochimecal study on bone formation in the palate (primary & secondary). Differences in bone growing were significant, the amount of Ca++ and phosphates was vigorously more deposited in the region and stained sharply with special days. Deformity of face and head region also appeared because of elastic band formation in hard palate. Formation in protein synthesis in faster growing of hard palate had caused palate undetachment from the tongue. Tongue, was attached to hard palate causing deformity in face and lower jaw and hard palate culminating in head conical and attachment of shoulder skin to lower part of the jaw.At the end of administration of lorazpam during the second half of the life of embryo, protein synthesis acceleration was proved and its effect on the growth hormon was sole treatagenic.

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APA: Copy

FAGHANI, M., NADIA SHARIFI, Z., & SALSABILI, N.. (2003). EFFECT OF LORAZPAM ON THE ANATOMICAL DEVELOPMENT OF MORPHOGENESIS OF THE SECONDARY PALATE IN THE RAT EMBRYO. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 10(36-37), 21-26. SID. https://sid.ir/paper/89952/en

Vancouver: Copy

FAGHANI M., NADIA SHARIFI Z., SALSABILI N.. EFFECT OF LORAZPAM ON THE ANATOMICAL DEVELOPMENT OF MORPHOGENESIS OF THE SECONDARY PALATE IN THE RAT EMBRYO. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2003;10(36-37):21-26. Available from: https://sid.ir/paper/89952/en

IEEE: Copy

M. FAGHANI, Z. NADIA SHARIFI, and N. SALSABILI, “EFFECT OF LORAZPAM ON THE ANATOMICAL DEVELOPMENT OF MORPHOGENESIS OF THE SECONDARY PALATE IN THE RAT EMBRYO,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 10, no. 36-37, pp. 21–26, 2003, [Online]. Available: https://sid.ir/paper/89952/en

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