ASSOCIATION OF POLYMORPHISM-308 TNF-ALPHA PROMOTER WITH TYPE 2 DIABETES MELLITUS (A CASE-CONTROL STUDY)

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GOLSHANI H.; DOUSTI M.; SAYEHMIRI F.; HAGHANI K.; BAKHTIYARI S.

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Journal: Journal of Ilam University of Medical Sciences Year:2014 | Volume:22 | Issue:5 Page(s): 1-10

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Title

ASSOCIATION OF POLYMORPHISM-308 TNF-ALPHA PROMOTER WITH TYPE 2 DIABETES MELLITUS (A CASE-CONTROL STUDY)

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Keywords

TYPE 2 DIABETESQ1

INSULIN RESISTANCEQ1

308 TNF-α PROMOTERQ2

KURDQ2

Abstract

Introduction: Tumor necrosis factor a (TN-F-a) is a potent cytokine, which is originally identified as a factor implicated in inflammatory and immunoregulatory actions and it plays a role in the development of obesity, INSULIN RESISTANCE, and probability of TYPE 2 DIABETES. The objectives of the present study were to evaluate the association of -308 TNF-a promoter polymorphism with TYPE 2 DIABETES Mellitus.Materials & Methods: In all, 173 patients with T2DM and 173 normoglycemic subjects were included in this study. All subjects were genotyped using polymerase chain reaction-restriction fragment length and allelic frequencies were then analyzed in each group. Serum lipids, fasting glucose, fasting serum insulin, HOMA-IR, and H-bA1c levels were determined by conventional methods. Data was analyzed using SPSS software.Findings: The allelic frequency of the ‘A’ allele, was significantly different between case and control groups (P=0.006). Also, the genotype frequencies showed a significant difference in GA genotype between case and control individuals (OR=3.67, 95% CI=1.61-8.35, P=0.002). Similarly, the 308 TNF-alpha was found to be significantly associated with T2DM (OR=3.65, 95% CI=1.66-8.02, P=0.001) for the dominant model. But, no significant association was observed for recessive model (P>0.05). Discussion & Conclusion: This is the first study performed in KURDish ethnic group from West Iran. The findings of this study revealed that the allele and genotype frequency of GA variation had a significant difference between case and control groups. Also, the 308 TNFa was found to be significantly associated with T2DM for the dominant model.

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APA: Copy

GOLSHANI, H., DOUSTI, M., SAYEHMIRI, F., HAGHANI, K., & BAKHTIYARI, S.. (2014). ASSOCIATION OF POLYMORPHISM-308 TNF-ALPHA PROMOTER WITH TYPE 2 DIABETES MELLITUS (A CASE-CONTROL STUDY). JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 22(5), 1-10. SID. https://sid.ir/paper/90114/en

Vancouver: Copy

GOLSHANI H., DOUSTI M., SAYEHMIRI F., HAGHANI K., BAKHTIYARI S.. ASSOCIATION OF POLYMORPHISM-308 TNF-ALPHA PROMOTER WITH TYPE 2 DIABETES MELLITUS (A CASE-CONTROL STUDY). JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;22(5):1-10. Available from: https://sid.ir/paper/90114/en

IEEE: Copy

H. GOLSHANI, M. DOUSTI, F. SAYEHMIRI, K. HAGHANI, and S. BAKHTIYARI, “ASSOCIATION OF POLYMORPHISM-308 TNF-ALPHA PROMOTER WITH TYPE 2 DIABETES MELLITUS (A CASE-CONTROL STUDY),” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 5, pp. 1–10, 2014, [Online]. Available: https://sid.ir/paper/90114/en

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