EFFECT OF DIBENZO-18-CROWN-6 ON HAEMATOPOITIC CELLS COLONY FORMATION OF MOUSE BONE MARROW

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MASHHADI AKBAR BOUJAR M.; PARIVAR KAZEM; SHOKRAVI ABAS; MOULAEI MARAL

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2009 | Volume:18 | Issue:4 (54) Page(s): 209-215

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

816

Download:

Cites:

Information Journal Paper

Title

EFFECT OF DIBENZO-18-CROWN-6 ON HAEMATOPOITIC CELLS COLONY FORMATION OF MOUSE BONE MARROW

Author(s)

MASHHADI AKBAR BOUJAR M. | PARIVAR KAZEM | SHOKRAVI ABAS | MOULAEI MARAL | Issue Writer Certificate

Keywords

DIBENZO- 18- CROWN-6Q3

RED BONE MARROWQ3

COLONY FORMATIONQ3

Abstract

Background: Known biological effects of crown ethers influence us to investigate its effect in human body and use in drug production. The aim of this study was to evaluate the effects of Dibenzo-18-crown-6 on COLONY FORMATION of bone marrow cells of mouse in culture medium and to find the probable mechanisms of the process.Materials and Methods: In this experimental study, RED BONE MARROW cells of mouse (Balb/C) were used as source of haemapoietic stem cells. Culture of RED BONE MARROW cells was done in the form of semi solid in the presence of different concentrations of crown ether, cAMP, PHO4H2K and PO4H2Na.Results: Different concentrations of crown ether have significant inhibitory effects on colonizing of RED BONE MARROW cells. The maximum inhibitory effect was observed in concentration of 80 mg/ml crown ether and no colony was found. The inhibitory effects of crown ether was diminished in the presence of cAMP with concentration of 10×10-6 mol, PO4H2Na with concentration of 10×10-6 mol and PO4H2K with concentration of 5×106 mol, but it couldn’t achieve the level of control group without presence of crown ether. HPLC method demonstrated that remaining level of crown ether reached to zero after sixth hour.Conclusion: The inhibitory effects of crown ether in control of colonizing the RED BONE MARROW cells occur via decreasing of cations value and changing the physiological function of membrane resulting disorder in the cAMP signaling pathway.

Cites

No record.

References

No record.

Cite

APA: Copy

MASHHADI AKBAR BOUJAR, M., PARIVAR, KAZEM, SHOKRAVI, ABAS, & MOULAEI, MARAL. (2009). EFFECT OF DIBENZO-18-CROWN-6 ON HAEMATOPOITIC CELLS COLONY FORMATION OF MOUSE BONE MARROW. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 18(4 (54)), 209-215. SID. https://sid.ir/paper/98938/en

Vancouver: Copy

MASHHADI AKBAR BOUJAR M., PARIVAR KAZEM, SHOKRAVI ABAS, MOULAEI MARAL. EFFECT OF DIBENZO-18-CROWN-6 ON HAEMATOPOITIC CELLS COLONY FORMATION OF MOUSE BONE MARROW. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2009;18(4 (54)):209-215. Available from: https://sid.ir/paper/98938/en

IEEE: Copy

M. MASHHADI AKBAR BOUJAR, KAZEM PARIVAR, ABAS SHOKRAVI, and MARAL MOULAEI, “EFFECT OF DIBENZO-18-CROWN-6 ON HAEMATOPOITIC CELLS COLONY FORMATION OF MOUSE BONE MARROW,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 18, no. 4 (54), pp. 209–215, 2009, [Online]. Available: https://sid.ir/paper/98938/en

Related Journal Papers