سال:1394 | دوره:3 |تعداد مقالات:122

INTRODUCTION & AIM: VENIPUNCTURE IN GASTROINTESTINAL CANCER PATIENTS IS VERY DIFFICULT AND PAINFUL BECAUSE OF USING CHEMOTHERAPY DRUGS. THEREFORE, THIS STUDY AIMED TO COMPARE THE EFFECT OF CARDAMOM AROMA AND MUSIC THERAPY ON VENIPUNCTURE PAIN IN PATIENTS WITH GASTROINTESTINAL CANCER...

INTRODUCTION & AIM: TGIF2LX (TRANSFORMING GROWTH FACTOR BETA-INDUCED FACTOR 2 LIKE, X-LINKED) IS A HOMEODOMAIN (HD) PROTEIN THAT HAS BEEN IMPLICATED IN THE NEGATIVE REGULATION OF CELL SIGNALING PATHWAYS. THE AIM OF THIS STUDY WAS TO INVESTIGATE THE POSSIBLE FUNCTIONS OF TGIF2LX IN COLON ADENOCARCINOMA...

INTRODUCTION: THE AIM OF THE STUDY IS TO ASCERTAIN HER2 POSITIVITY IN GASTRIC CANCER WITCH OPERATED IN OUR CENTER AND TO EVALUATE ITS CORRELATION WITH STAGING AND RESPONSE TO TREATMENT...

INTRODUCTION: PEDIATRIC ONCOLOGY PATIENTS DEVELOPED SIMILAR ABDOMINAL EMERGENCIES AS IMMUNOCOMPETENT CHILDREN IN ADDITION TO ACUTE ABDOMEN FROM MALIGNANCY OR SECONDARY TREATMENT. CYTOTOXIC CHEMOTHERAPY, RADIOTHERAPY AND EXTENSIVE SURGICAL RESECTION ALL CONTRIBUTE TO THE RISK OF GASTROINTESTINAL SYMPTOMS. IMMUNOCOMPROMISED CHILDREN MAY LACK THE INFLAMMATORY SIGNS OF ACUTE ABDOMEN MAKING PROMPT DIAGNOSIS OF PEDIATRIC ONCOLOGIC ABDOMINAL EMERGENCIES CHALLENGING...

INTRODUCTION: OVARIAN EPITHELIAL CARCINOMA IS ONE OF THE MOST COMMON GYNECOLOGICAL CANCERS AND COLORECTAL CANCER IS THE FOURTH MOST COMMON CANCER IN MEN AND THE THIRD MOST COMMON IN WOMEN. HEREIN, WE REPORT A PATIENT WHO PRESENTED WITH AN ADENOCARCINOMA OF THE COLON OF FOURTEEN YEARS AFTER AN OVARIAN ADENOCARCINOMA...

BACKGROUND AND AIM: THE HYPOTHESIS THAT NON-SECRETOR STATUS OF INDIVIDUALS MAKES THEM MORE SUSCEPTIBLE TO CERTAIN BACTERIAL INFECTIONS AND THEY MIGHT BE AT A GREATER RISK OF METABOLIC SYNDROMES AND AUTOIMMUNE DISEASES MOTIVATED US TO EVALUATE THE RELATIONSHIP BETWEEN SECRETOR STATUS AND RISK FACTORS FOR DUODENAL ULCER IN THE PRESENT STUDY...

INTRODUCTION: STATISTICS SHOW THAT CANCER INCLUDING THREE LEADING CAUSES OF DEATH IN THE WORLD AND IN TERMS OF EPIDEMIOLOGY, DUE TO VARIOUS FACTORS INVOLVED ARE COMPLICATED. THE INCIDENCE OF THE DIFFERENT HISTOLOGICAL TYPES OF CANCER VARIES GREATLY BETWEEN VARIOUS POPULATIONS AND IS ATTRIBUTED TO OCCUPATIONAL, SOCIAL, CULTURAL, RACIAL (POSSIBLY HEREDITARY), AND GEOGRAPHIC INFLUENCES...

INTRODUCTION AND AIM: RECENTLY NANOPARTICLES HAVE SHOWN GREAT POTENTIAL TO BE USED IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS IN NUCLEAR MEDICINE. CHITOSAN NANOPARTICLES HAVE GAINED MORE ATTENTION AS DRUG DELIVERY CARRIERS BECAUSE OF THEIR BETTER STABILITY, LOW TOXICITY, SIMPLE AND MILD PREPARATION METHOD. DUE TO EXCELLENT BIOCOMPATIBILITY AND BIODEGRADABILITY OF CHITOSAN, HAVE BEEN USED EXTENSIVELY FOR PHARMACEUTICAL APPLICATION AND RADIOPHARMACEUTICAL IN NUCLEAR MEDICINE...

INTRODUCTION & AIM: THE FLUOROPYRIMIDINE DRUG 5-FLUOROURACIL (5-FU) AND THE PRODRUG CAPECITABINE, HAVE BEEN EXTENSIVELY USED FOR TREATMENT OF MANY TYPES OF CANCER INCLUDING COLORECTAL, GASTRIC AND HEAD AND NECK. APPROXIMATELY 10% OF THE PATIENTS SUFFER FROM SEVERE FLUOROPYRIMIDINE-INDUCED TOXICITY, LIKE DIARRHEA, MUCOSITIS, MYELOSUPPRESSION AND HAND-FOOT SYNDROME. THIS MAY LEAD TO DOSE REDUCTION AND TREATMENT DISCONTINUATION. PHARMACOGENETICS RESEARCH COULD BE USEFUL FOR IDENTIFICATION OF PREDICTIVE MARKERS IN CHEMOTHERAPY TREATMENT...

INTRODUCTION & AIM: EPIGENETIC ABNORMALITIES, INCLUDING CHANGES IN DNA METHYLATION, HAVE BEEN OBSERVED IN MANY TYPES OF CANCER, INCLUDING COLORECTAL CANCER (CRC). COLORECTAL CANCER IS THE THIRD MOST COMMON CANCER AND THE FOURTH LEADING CAUSE OF DEATH IN THE WORLD. TUMOR SUPPRESSOR EYA4 GENE THAT ACTS BY INDUCING UPREGULATION OF DKK1 AND INHIBITING THE WNT SIGNALING PATHWAY THAT WNT SIGNALING PLAYS AN IMPORTANT ROLE IN CRC CARCINOGENESIS...

YTTRIUM-90 (90Y) RADIOEMBOLISATION (RE) IS INCREASINGLY USED FOR THE TREATMENT OF PATIENTS WITH UNRESECTABLE PRIMARY OR METASTATIC LIVER TUMOURS. IMAGE-BASED APPROACHES TO ASSESS MICROSPHERE DISTRIBUTION AFTER RE HAVE GAINED INTEREST BUT ARE MOSTLY HAMPERED BY THE LIMITED IMAGING POSSIBILITIES OF THE ISOTOPE 90Y...

INTRODUCTION: COLORECTAL CANCER IS ONE OF THE MOST COMMON GASTROINTESTINAL CANCER, ABOUT 10 PERCENT OF CANCER DEATHS ACCOUNTED FOR. COLORECTAL CANCER IS THE FIFTH MOST COMMON CANCER IN WOMEN BRAS AND IRANIAN MEN TAKEN INTO ACCOUNT. THE CLOSE ASSOCIATION BETWEEN COLORECTAL CANCER AND LIFESTYLE AND EATING BEHAVIORS SHOWN. SO THAT PROPER NUTRITION CAN PREVENT MORE THAN 50% OF THE CASES CAN BE PREVENTED. THIS STUDY AIMED TO REVIEW THE RELATIONSHIP BETWEEN NUTRITIONAL FACTORS AND COLORECTAL CANCER...

INTRODUCTION & AIM: COLORECTAL CANCER IS THE DEVELOPMENT OF CANCER FROM THE COLON OR RECTUM THAT HAVE THE ABILITY TO INVADE OR SPREAD TO OTHER PARTS OF THE BODY.COLORECTAL CANCER IS A MAJOR WORLDWIDE HEALTH PROBLEM OWING TO ITS HIGH PREVALENCE AND MORTALITY RATES. THE CUCURBITACINS ARE A GROUP OF TETRACYCLIC TRITERPENOIDS DERIVED FROM THE CUCURBITANE SKELETON AND FOUND PRIMARILY IN THE CUCURBITACEAE FAMILY. A FACT WHICH HAS GIVEN RISE TO SEVERAL STUDIES CONCERNING THEIR POTENTIAL USE AS ANTIINFLAMMATORY AND ANTICANCER AGENTS...

INTRODUCTION & AIM: GASTRIC CANCER IS AMONG THE LEADING CAUSES OF CANCER-RELATED DEATH, AND THE SYMPTOMS ARE COMMONLY CHARACTERIZED IN ADVANCED STAGES. HISTONE ACETYLATION IS AMONG THE MOST IMPORTANT EPIGENETIC ALTERATIONS OCCURRING DURING CANCER DEVELOPMENT. IN ADDITION, REDUCED E-CADHERIN EXPRESSION IS A MAJOR CONTRIBUTOR IN THE PROCESS OF TUMOR CELL INVASION AND METASTASIS. OXAMFLATIN IS A HISTONE DEACETYLASE INHIBITOR THAT HAS BEEN SUGGESTED AS A PROMISING ANTI-TUMOR AGENT; YET ITS EFFECT ON THE VIABILITY AND INVASION OF GASTRIC TUMOR CELLS IS UNCLEAR. WE AIMED TO ASSESS THE IMPACT OF OXAMFLATIN ON THE VIABILITY OF GASTRIC TUMOR CELLS AND EXPRESSION OF E-CADHERIN AS A MARKER OF TUMOR INVASION SUSCEPTIBILITY...

INTRODUCTION & AIM: COLORECTAL CANCER (CRC) IS ONE OF THE MOST COMMON TYPES OF CANCERS IN THE WORLD. VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) HAS AN ESSENTIAL ROLE IN TUMOR ANGIOGENESIS AND INVOLVED IN THE GROWTH AND PROGRESSION OF CRC. KDR (VEGFR2) IS THE MAIN PRO-ANGIOGENIC RECEPTOR FOR VEGF AND SEEMS TO PLAY AN IMPORTANT CRUCIAL ROLE IN TUMOR ANGIOGENESIS. THE AIMS OF THIS STUDY WERE TO MEASURE RELATIVE EXPRESSION OF KDR GENE IN TUMOR AND MARGINAL TISSUES IN CRC PATIENTS AND TO ASSAY THE CORRELATION OF KDR MRNA EXPRESSION LEVEL WITH CLINICO-PATHOLOGICAL FACTORS...

INTRODUCTION & AIM: COLORECTAL CANCER IS ONE OF THE MAIN CAUSES OF CANCER RELATED DEATH WORLDWIDE. CRC ARISES FROM MUTATIONS IN DIFFERENT GENES. ONE OF THE MOST IMPORTANT MUTATIONS IN THIS TYPE OF CANCER IS IN THE K-RAS (KIRSTEIN RAT SARCOMA) GENE. THE MOST IMPORTANT MUTATIONS IN KRAS GENE OCCUR IN 12TH AND 13TH CODON OF THE SECOND EXON. MUTATIONS THAT OCCUR IN THIS AREA, ARE VERY IMPORTANT FOR PREDICTING THE RESPONSE OF PATIENTS TO ANTI-EGFR THERAPIES LIKE CTUXIMAB AND PANITUMUMAB. IN THIS STUDY WE AIMED TO STUDY THESE MUTATIONS BY TWO DIFFERENT METHODS...

INTRODUCTION & AIM: THE THIRD MOST COMMON CAUSE OF CANCER DEATH IN THE WORLD IS GASTRIC CANCER. THE POTENTIAL TREATMENTS OF DIFFERENT CHEMOTHERAPY AGENTS HAVE BEEN EVALUATED FOR GASTRIC CANCERS. RECENT RESEARCHES HAVE BEEN FOCUSED ON NATURAL AGENTS WHICH LESS TOXIC AND EFFICIENT. PINEAPPLE EXTRACT, A NATURAL COMPOUND, HAVE BEEN INVESTIGATED AS A POTENTIATED ANTICANCER EXTRACT. THE AIM OF THIS STUDY WAS PERFORMED TO EVALUATE THE CYTOTOXIC EFFECTS OF PINEAPPLE EXTRACT ON, HUMAN GASTRIC (AGS) CELLS UNDER IN VITRO CONDITIONS...

INTRODUCTION: COLORECTAL CANCER IS THE THIRD PREVALENT CANCER IN THE WORLD AND THE SECOND CAUSE OF DEATH AMONG THE CANCERS. CONSIDERING THE INCREASING TREND OF THIS CANCER, A STUDY WAS APPLIED WITH THE OBJECTIVE OF DETECTING THE RISK FACTORS OF COLORECTAL CANCER...

LIVER METASTASES ARE A FREQUENT ONCOLOGICAL SITUATION IN COLORECTAL CANCER AND GLOBALLY ONLY 20% OF PATIENTS PRESENTING THEM ARE CANDIDATES FOR SURGICAL RESECTION. WHILE SYSTEMIC CHEMOTHERAPY IS AN OPTION FOR PATIENTS PRESENTING SIGNIFICANT METASTATIC DISEASE BURDEN, RADIOTHERAPY (RT) IS A SAFE, WELL-TOLERATED LOCAL TREATMENT THAT CAN OFFER A LONGER TUMOR CONTROL AND SYMPTOMS CONTROL...

BACKGROUND: STOMACH CANCER (SC) IS THE SECOND LEADING CAUSE OF CANCER DEATH WITH THE RATE OF 10.4% IN THE WORLD. THE CORRELATION BETWEEN THE INCIDENCE AND MORTALITY RATES OF SC AND HUMAN DEVELOPMENT INDEX (HDI) HAS NOT BEEN GLOBALLY DETERMINED. THEREFORE, THIS STUDY AIMED TO DETERMINE THE ASSOCIATION BETWEEN THE INCIDENCE AND MORTALITY RATES OF SC AND HDI IN VARIOUS REGIONS...

INTRODUCTION & AIM: COLORECTAL CANCER IS ONE OF THE MOST COMMON CANCERS IN THE WORLD, WITH OVER 1.2 MILLION NEW CASES DIAGNOSED EACH YEAR. DESPITE IMPROVEMENTS IN SCREENING FOR EARLY DIAGNOSIS, A HISTORY OF BREAST CANCER CONTINUES TO BE REPORTED AS A RISK FACTOR FOR COLORECTAL CANCER...

INTRODUCTION & AIM: GASTRIC CANCER IS NOW THE FIFTH MOST COMMON CANCER IN THE WORLD, AND THE THIRD LEADING CAUSE OF CANCER DEATH. THE CUCURBITACINS ARE A GROUP OF TETRACYCLIC TRITERPENOIDS FOUND PRIMARILY IN THE CUCURBITACEAE FAMILY...

INTRODUCTION: NOW CANCER IS AMONG THE TOP THREE CAUSES OF DEATH IN DEVELOPED COUNTRIES AND ALSO IN IRAN.THE INCIDENCE OF CANCER VARIES IN DIFFERENT SOCIETIES AND ITS EPIDEMIOLOGICAL CHARACTERISTICS, ESPECIALLY GASTROINTESTINAL CANCERS IN RECENT DECADES HAS BEEN A FUNDAMENTAL CHANGE.THE AIM OF THIS STUDY IS TO DETERMINE THE EPIDEMIOLOGY OF GASTROINTESTINAL CANCERS IN IRAN...

COLORECTAL CANCER (CRC) IS ONE OF THE MOST COMMON CANCERS IN THE WORLD AND CARRIES THE SECOND HIGHEST MORTALITY RATE. CANCER STEM CELLS (CSCS) ARE A SMALL GROUP OF CELLS IN TUMOR TISSUE WITH THE CHARACTER OF STEM CELL, SUCH AS THE POTENTIAL OF SELF-RENEW, MULTILINEAGE DIFFERENTIATION, MULTIDRUG RESISTANCE AND TUMORI-GENESIS. THEY SHOW CHARACTERISTICS OF TUMOR CELL, SUCH AS THE ABNORMAL OF PROTO-ONCOGENE AND TUMOR SUPPRESSOR GENE. THEIR DAUGHTER CELLS ARE INCOMPLETE DIFFERENTIATION AND WITH FUNCTIONAL DEFECTS...

COLORECTAL CANCER (CRC) IS THE FOURTH MOST COMMON CAUSE OF CANCER MORTALITY WORLDWIDE. PATIENTS WITH LYNCH AND FAP, TOGETHER WITH POSITIVE FAMILY HISTORY CONSTITUTING UP TO 30% OF CRC. MICROSATELLITE INSTABILITY (MSI) ABOUT 15% OF SPORADIC CRC. MUTATIONS IN THE MISMATCH REPAIR (MMR) GENES SUCH AS HMLH1 OR HMSH2 GENES AND CPG ISLAND METHYLATOR PHENOTYPE (CIMP) HIGH ESPECIALLY IN MLH1 AND MSH2 ARE THE MOST COMMON DEFECTS THAT HAVE BEEN SEEN IN THESE PATIENTS...

INTRODUCTION & AIM: COLORECTAL CANCER IS THE THIRD MOST COMMON CANCER IN THE WORLD AND GENETIC AND EPIGENETIC ALTERATIONS PLAY AN IMPORTANT ROLE IN ITS DEVELOPMENT. TUMOR SUPPRESSOR OGDHL GENE IS ONE OF THE SUBUNIT OF OXOGLUTARATE DEHYDROGENASE COMPLEX WHICH IS INVOLVED IN THE TCA CYCLE AND IS INDIRECTLY RESPONSIBLE FOR THE INDUCTION OF APOPTOSIS. METHYLATION OF ITS PROMOTER CAN REDUCE ITS EXPRESSION WHICH IN ITS TURN MAY AFFECT THE PROCESS OF APOPTOSIS. THIS STUDY WAS AIMED TO COMPARE THE METHYLATION STATUS OF THE PROMOTER REGIONS OF OGDH LGENE IN TUMORAL AND NONTUMORAL SAMPLES OF PATIENTS WITH COLORECTAL CANCER...

INTRODUCTION & AIM: CANCER IS ONE OF THE MAJOR CAUSES OF DEATH (13%) IN THE WORLD AND THE THIRD LEADING CAUSE OF DEATH IN IRAN. THE EXACT CAUSE OF THE DISEASE IN MODERN MEDICINE, IS UNCLEAR. IT IS ESTIMATED THAT MORE THAN A THIRD OF CASES IF DETECTED EARLY, ARE CURABLE. IN THE VIEWPOINTS OF TRADITIONAL PERSIAN MEDICINE (TPM), CANCER IS A TYPE OF SWELLING AND THE AIM OF THIS STUDY IS TO DERIVE THE PRODUCT BASED ON TRADITIONAL PERSIAN MEDICINE TO HELP CANCER TREATMENT...

INTRODUCTION: THE INCIDENCE OF PRIMARY COLORECTAL LYMPHOMAS IS RARE, COMPRISING 10-20% OF GASTROINTESTINAL LYMPHOMAS AND ONLY 0.2-0.6% OF LARGE BOWEL MALIGNANCIES. THE AIM OF THIS STUDY IS REPORT A RARE CASE WITH RECTAL ADENOCARCINOMA IN PATIENT WITH DIFFUSE LARGE B-CELL LYMPHOMA OF THE ILEOCECAL...

1. OPTIMAL SURGERY (TME AND APE) REDUCE LOCAL RECURRENCE AND IMPROVE SURVIVAL.2. GOOD MRI MAY GUIDE SURGERY AND SELECTIVE PREOPERATIVE RADIOTHERAPY. 3. RADIOTHERAPY AND SURGERY OVERTREATMENT MAY LEAD TO POORER QUALITY OF LIFE...

INTRODUCTION & AIM: THE APOPTOTIC FACTORS SUCH AS BID, BIM AND APAF1 HAVE A MAIN ROLE IN INDUCING APOPTOTIC PATHWAYS. FURTHERMORE, SOME COMPOUNDS SUCH AS CARVACROL CAN ACTIVE THESE APOPTOTIC FACTORS TO CAUSE APOPTOSIS. IN THIS STUDY, THE COMET ASSAY TECHNIQUE AND MOLECULAR DYNAMICS SIMULATIONS WERE APPLIED TO INVESTIGATE THE EFFECTS OF CARVACROL ON INDUCTION OF APOPTOTIC PATHWAY...

WNT SIGNAL TRANSDUCTION PATHWAYS ARE FUNDAMENTAL MECHANISMS THAT DIRECT CELL PROLIFERATION, CELL POLARITY AND CELL FATE DETERMINATION DURING EMBRYONIC DEVELOPMENT AND CELLULAR HOMEOSTASIS. THE CANONICAL WNT SIGNALING PATHWAY FUNCTIONS BY REGULATING THE PROTEIN STABILIZATION OF B-CATENIN, A TRANSCRIPTIONAL CO ACTIVATOR THAT CONTROLS THE EXPRESSION OF SOME IMPORTANT CELLULAR GENES. UPREGULATION OF B-CATENIN TRANSCRIPTIONAL ACTIVITY CAN LEAD TO NUMEROUS FORMS OF HUMAN CANCER, MOST NOTABLY HEREDITARY AND SPORADIC FORMS OF COLON CANCER...

INTRODUCTION: ACCORDING TO A CHANGE IN THE TREND OF INCREASING INCIDENCE OF DISEASES AND NON-COMMUNICABLE DISEASES IN THE COUNTRY AND THE BROAD IMPACT OF THESE DISEASES ON PREMATURE DEATH, THE IMPORTANCE OF CANCER IS OBVIOUS TO EVERYBODY IN SOCIETY, REGARDING TO THE FACT THAT GASTROINTESTINAL CANCER IS THE MOST COMMON CANCERS, THIS STUDY EXAMINES THE EPIDEMIOLOGY OF DEATH DUE TO GASTROINTESTINAL TRACT IN THE CITY OF ALBORZ IN 1393.

INTRODUCTION & AIM: HEPATITIS B VIRUS (HBV) IS THE LEADING CAUSE OF CIRRHOSIS AND HEPATOCELLULAR CARCINOMA (HCC) IN THE WORLD. THE MAIN GOAL OF THERAPY IN CHRONIC HEPATITIS B (CHB) PATIENTS INCLUDES THE DRIVING VIRAL REPLICATION TO THE LOWEST POSSIBLE LEVEL IN ORDER TO HALT THE PROGRESSION OF CHRONIC HEPATITIS TO PREVENT THE DEVELOPMENT OF LIVER FAILURE, DUE TO SUBSEQUENT LIVER CIRRHOSIS, AND THE EMERGENCE OF HCC. THE AIM OF THIS STUDY WAS THE DETECTION OF RTA181T/SW172* MUTANT FREQUENCY AMONG CHRONIC HBV PATIENTS WHO SHOW INCOMPLETE RESPONSE TO ANTIVIRAL THERAPY...

INTRODUCTION & AIM: CANCER IS ONE OF THE CHRONIC DISEASES THAT REDUCE THE SPIRITUAL WELL-BEING AND LIFE SATISFACTION. THEREFORE, THIS RESEARCH AIMED TO DETERMINE THE EFFECT OF EDUCATIONAL INTERVENTION ON SPIRITUAL WELL-BEING AND LIFE SATISFACTION OF PATIENTS WITH GASTROINTESTINAL CANCER IN CITY OF ILAM...

WITH OPTIMAL MRI STAGING, NEOADJUVANT (CHEMO) RADIATION (CHRT) IN HIGH RISK PATIENTS, AND GOOD SURGERY (TOTAL MESORECTAL EXCISION), LOCAL RECURRENCE RATES ARE DOWN TO 5%. THIS IMPROVED ONCOLOGICAL OUTCOME COMES AT A COST. ESPECIALLY FOR THE ELDERLY AND IN PATIENTS WITH COMORBIDITY, RECTAL RESECTIONS ARE FORMIDABLE PROCEDURES WITH SUBSTANTIAL PERI-OPERATIVE MORBIDITY AND MORTALITY...

INTRODUCTION & AIM: GASTRIC CANCER IS CONSIDERED AS A MAJOR CAUSE OF DEATH FROM CANCER WORLDWIDE, ALTHOUGH ITS INCIDENCE HAS DECREASED DURING THE LAST DECADE. GASTRIC CANCER IS THE LEADING CAUSE OF CANCER DEATH IN IRAN AND KURDISTAN PROVINCE IS AMONG THE PROVINCES WITH THE HIGHEST INCIDENCE RATE...

INTRODUCTION: COLORECTAL CANCER IS THE FOURTH MOST COMMON CANCER IN MEN AND THE THIRD MOST COMMON IN WOMEN. BRUCELLA INFECTIONS IN IMMUNE COMPROMISED HOSTS (LIKE CLL) ARE RELATIVELY RARE. HEREIN, WE REPORTED FIRST CASE REPORT, A PATIENT HAVE BEEN DIAGNOSED AS SIMULTANEOUS CLL AND BRUCELLOSIS DURING HIS FOLLOW UP THAT SHE INDICATED A SUBSEQUENT NEOPLASM AFTER CLL ACCORDING TO OUR KNOWLEDGE...

A GREAT DEAL OF RESEARCH HAS DEMONSTRATED THE EXISTENCE OF CANCER STEM CELLS (CSCS) IN SEVERAL HUMAN CANCERS IN RECENT YEARS. CSCS ARE MINOR POPULATION OF TUMORIGENIC CELLS THAT ARE CAPABLE OF CONTINUOUS SELF-RENEWAL AND DIFFERENTIATION WHICH MAY BE REGULATED BY SOME SIGNALING PATHWAYS INCLUDING WNT/B-CATENIN, HEDGEHOG, AND NOTCH. IN ADDITION, RECENT STUDIES INDICATE THAT CSCS MAY BE RESPONSIBLE FOR TUMOR RELAPSE AND RESISTANCE TO THERAPY...

INTRODUCTION & AIM: THE PROGNOSIS OF COLORECTAL CANCER IS RELATIVELY GOOD IN TERMS OF SURVIVAL. IN MANY PROGNOSTIC STUDIES, PATIENTS MAY BE EXPOSED TO SEVERAL TYPES OF COMPETING EVENTS. THESE DIFFERENT CAUSES OF DEATH ARE CALLED COMPETING RISKS. TO INVESTIGATE THE PROGNOSIS FACTORS OF SURVIVAL OF PATIENTS WITH COLORECTAL CANCER IN PRESENCE OF COMPETING RISKS, USING. FOUR-PARAMETER LOG-LOGISTIC DISTRIBUTION...

INTRODUCTION & AIM: GASTRIC CANCER (GC) IS THE FOURTH HUMAN MALIGNANT DISEASE AND THE SECOND LEADING CAUSE OF CANCER DEATH IN THE WORLD. THIS CANCER IS AN ASYMPTOMATIC DISEASE AT EARLY STAGES AND SO IS OFTEN DETECTED AT ADVANCED STAGE. CIRCULATING MICRORNAS PLAY AN IMPORTANT ROLE IN DIAGNOSIS AND ASSESSMENT OF PATIENTS WITH CANCER AND THEREFORE DISCOVERY OF THESE MOLECULES IS PROMISING TO USE OF THEM AS NONINVASIVE BIOMARKERS IN THE SCREENING OF CANCER PATIENTS. IN THE PRESENT STUDY, WE ANALYZED THE EXPRESSION OF MIR-103 IN PLASMA OF VOLUNTEERS WITH GC AND HEALTHY INDIVIDUALS TO INVESTIGATE FUNCTION OF THIS MOLECULE AS A NON-INVASIVE DIAGNOSTIC BIOMARKER...

INTRODUCTION: RECORDS FROM THE CANCER REGISTRY SYSTEM OF IRAN INDICATE THAT CRC IS THE THIRD AND FOURTH MOST COMMON CANCER IN IRANIAN MEN AND WOMEN RESPECTIVELY. IT IS ESTABLISHED THAT CRC IS A COMPLEX DISEASE, AND ITS INCIDENCE IS RELATED TO BOTH GENETIC AND ENVIRONMENTAL FACTORS. IN THIS STUDY WE INVESTIGATED THE ENVIRONMENTAL FACTORS ASSOCIATED WITH COLORECTAL CANCER IN ISFAHAN, IRAN...

INTRODUCTION & AIM: COLORECTAL CANCER IS THE SECOND COMMON GASTROINTESTINAL CANCERS AND THE THIRD COMMON CANCER IN IRAN. THE AIM OF THIS STUDY IS TO DETECT GEOGRAPHICAL DISTRIBUTION AND IDENTIFY HIGH RISK OR LOW RISK CLUSTERS OF COLORECTAL CANCER IN IRAN...

INTRODUCTION: STUDIES HAVE SHOWN THAT CANCER IS AMULTI FACTORIAL DISEASE THAT IN ITS PATHOGENESIS, IN ADDITION TO GENETIC DISORDERS, THE EFFECT OF ENVIRONMENTAL FACTORS CAN ALSO BE POINTED. AMONG ALL ENVIRONMENTAL FACTORS, TOBACCO THAT CONSIDERED AS THE LEADING CAUSE OF RESPIRATORY AND CARDIOVASCULAR DISEASE PLAYS A KEY ROLE IN CANCER PATHOGENESIS AND PROGRESSION. MORE THAN 5, 000 CHEMICALS AND 62 CARCINOGENES HAVE BEEN DETECTED IN TOBACCO, WHICH COULD CONTRIBUTE TO TUMORGENESIS THROUGH ACTIVATING ONCOGENES, INHIBITION OF TUMOR SUPPRESSOR GENES, GENETIC AND EPIGENETIC CHANGES, ALTERATION OF GROWTH PATHWAYS, ANGIOGENESIS AND METASTASIS...

INTRODUCTION AND AIM: PH GRADIENT IN CANCER CELLS IS DIFFERING FROM NORMAL CELLS. IT IS BECAUSE OF PRODUCTION OF LACTIC ACID AND HYDROLYSIS OF ATP IN TUMOR HYPOXIC ENVIRONMENT. ACCOMMODATION WITH THIS MORE ACIDIC SITUATION IS CRUCIAL FOR CANCER CELLS VIABILITY ALSO METASTATIC POTENTIAL. FOR THIS REASON PH-REGULATING FACTORS IMPORTANCE IS OBVIOUS. OUR STUDY INDICATES A NEW CHLORIDE CHANNEL IN HEPATOCYTE ROUGH ENDOPLASMIC RETICULUM (RER) THAT WAS PH-SENSITIVE...

NEUROENDOCRINE TUMORS (NETS) ARE A GENETICALLY DIVERSE GROUP OF MALIGNANCIES THAT SOMETIMES PRODUCE PEPTIDES THAT CAUSE CHARACTERISTIC HORMONAL SYNDROMES. NETS CAN BE CLINICALLY SYMPTOMATIC (FUNCTIONING) OR SILENT (NONFUNCTIONING); BOTH TYPES FREQUENTLY SYNTHESIZE MORE THAN ONE PEPTIDE, ALTHOUGH OFTEN THESE ARE NOT ASSOCIATED WITH SPECIFIC SYNDROMES...

INTRODUCTION & AIM: IT IS ESTIMATED THAT THE INCIDENCE OF CANCER BY 2025, DEVELOPED COUNTRIES WILL INCREASE BY ABOUT 45%. THE NATURE OF CANCER AND ITS TREATMENTS SUCH AS CHEMOTHERAPY, SURGERY AND RADIATION THERAPY, CHANGES THE COURSE OF LIFE AND CAUSING A LOT OF PROBLEMS THAT ALL THESE PROBLEMS CAN BE ALL PHYSICAL, PSYCHOLOGICAL, SOCIAL, ECONOMIC AND THE PATIENT'S FAMILY. THIS EXPERIENCE PSYCHOLOGICAL AND PHYSICAL SYMPTOMS SUCH AS CONSTIPATION AND DIARRHEA SYMPTOM INDICES CANCER PATIENTS CAN HAVE A MAJOR IMPACT ON QUALITY OF LIFE. THIS ARTICLE IS PART OF A RESEARCH WITH IRCT2015012720834N1 COD WHERE WE DECIDED TO THE IMPACT OF BLEND EDUCATIONAL PROGRAM FOR BOWEL ISSUES THAT AFFECT THE QUALITY OF LIFE FOR CANCER PATIENTS SHAFA 2014 MEASURE...

INTRODUCTION AND AIM: COLORECTAL CANCER IS THE MOST COMMON GASTROINTESTINAL CANCER. MORE THAN ONE MILLION NEW CANCER CASES ARE REGISTERED YEARLY. THE PREVALENCE OF COLORECTAL CANCER IN IRAN IS INCREASING. IDENTIFYING GENES AND PATHWAYS WITCH ARE INVOLVED IN CANCER AND GENE EXPRESSION CHANGES CAN HELP EARLY DIAGNOSIS AND TREATMENT. WE EVALUATED THE EXPRESSION OF NUDCD1, A TUMOR ANTIGEN, TO REACH A NEW MOLECULAR INSIGHT OF COLORECTAL CANCER...

INTRODUCTION: DESPITE REMARKABLE ADVANCES IN MEDICAL SCIENCE, CANCER CONTINUES TO BE ONE OF THE MOST IMPORTANT DISEASE OF THIS CENTURY AND THE SECOND LEADING CAUSE OF DEATH AFTER CARDIOVASCULAR DISEASES. DIAGNOSIS OF CANCER, PARTICULARLY CANCERS OF THE DIGESTIVE TRACT CAN MAKE SPIRITUAL DISTRESS IN PERSON. THIS STUDY AIMED TO INVESTIGATE THE ROLE OF SPIRITUALITY AND SPIRITUAL HEALTH IN PATIENTS WITH GASTROINTESTINAL CANCER...

INTRODUCTION AND AIMS: COLORECTAL CANCER (CRC), ONE OF THE MOST COMMON MALIGNANT DISORDERS, IS A MAJOR CAUSE OF DEATH WORLDWIDE. ALTHOUGH THE RATE OF INCIDENCE OF CRC INCREASES WITH AGE, BEGINNING AGE OF ITS INCIDENCE HAS OVERWHELMINGLY DECREASED LATELY. CRC SURVIVAL IS DEPENDENT UPON THE STATE OF DISEASE AT DIAGNOSIS, THEREFORE FINDING EARLY STAGE MOLECULAR INDICATORS RESULTS IN THE HIGHER CHANCE OF SURVIVAL. WE AIMED TO DETERMINE THE LEVEL OF PLXNA1 EXPRESSION IN CANCEROUS AND NONCANCEROUS TISSUES OF PATIENTS AT DIFFERENT STAGES OF CANCER TO DEVELOP OUR MOLECULAR INSIGHT OF CRC...

INTRODUCTION: GASTRIC CANCER IS THE SECOND REASON OF CANCER-RELATED DEATH IN THE WORLD WITH PARTICULARLY HIGH PREVALENCE IN EAST ASIA. RECENTLY, THE FUNCTION OF LONG NON-CODING RNAS (LNCRNAS) AS TUMOR SUPPRESSORS OR ONCOGENE HAS APPEARED IN PREVALENT CANCER TYPES, SUCH AS GASTRIC CANCER. LINCRNA-P21 IS LOCATED UPSTREAM OF P21 GENE AND ACTIVATES ITS EXPRESSION UNDER THE CONTROL OF P53 TRANSCRIPTION FACTOR...

INTRODUCTION & AIM: MICRORNAS IN COLORECTAL CANCER (CRC) HAVE BEEN PROVIDED A NEW INSIGHT INTO THE CANCER DIAGNOSIS. THESE RNAS HAVE BEEN SUGGESTED AS RELIABLE AND STABLE BIOMARKERS FOR VARIOUS CANCERS. OUR STUDY AIMED TO ANALYZE THE MICRORNA EXPRESSION IN SERUM AND TISSUE SAMPLES IN CRC TO EXAMINE THE POTENTIAL VALUE OF THESE MOLECULES AS DIAGNOSTIC BIOMARKERS...

COLORECTAL CANCER (CRC) IS THE THIRD MOST COMMON CANCER AND THE FOURTH MOST COMMON CAUSE OF CANCER DEATH WORLDWIDE. IMMUNOTHERAPY MODALITIES INCLUDING IMMUNE CHECKPOINT INHIBITORS SUCH AS ANTI-PROGRAMMED DEATH 1 (PD-1) ANTIBODY AND ANTI-PROGRAMMED DEATH LIGAND 1 (PD-L1) ANTIBODY HAVE DEMONSTRATED EFFICACY IN A MULTITUDE OF HUMAN TUMOR TYPES. RECENT EVIDENCE SUPPORTS USE OF THESE ANTIBODIES IN TUMORS WITH MICROSATELLITE INSTABILITY (MSI-H)...

CURRENTLY, WITH GOOD PRE-OPERATIVE STAGING (MRI), NEOADJUVANT (CHEMO) RADIATION (CHRT), AND GOOD QUALITY SURGERY (TOTAL MESORECTAL EXCISION), LOCAL RECURRENCE RATES IN RECTAL CANCER ARE AS LOW AS 5%. HOWEVER, THIS EXCELLENT ONCOLOGICAL OUTCOME COMES WITH THE COST OF SUBSTANTIAL PERI-OPERATIVE MORBIDITY AND MORTALITY, AS WELL AS CONSIDERABLE LONG-TERM ANORECTAL AND UROGENITAL DYSFUNCTION. ULTRA-LOW ANASTOMOSES AND INTERSPHINCTERIC RESECTIONS, ESPECIALLY AFTER NEOADJUVANT RT OFTEN LEAVE THE PATIENT WITH A DUBIOUS DEGREE OF CONTINENCE.

COLORECTAL CANCER IS THE THIRD MOST COMMON CANCER IN THE WORLD AND IS THE FOURTH CAUSE OF DEATH DUE TO CANCER. EPIGENETIC MODIFICATIONS THAT INCLUDE POST-TRANSLATIONAL PROCESSES ON HISTONE SUCH AS ACETYLATION, METHYLATION OR PHOSPHORYLATION, IT MAY BE EFFECTIVE IN CANCER PROGRESSION. SINCE THE CONTROL COLORECTAL CANCER PREVALENCE IN THE COUNTRY WAS REQUIRED, IT INVESTIGATED THE RELATIONSHIP BETWEEN HISTONE DEACETYLASE ENZYMES WITH COLORECTAL CANCER IN THIS REVIEW...

INTRODUCTION & AIM: GLOBALLY, GASTROINTESTINAL CANCERS ARE THE MOST COMMON CANCERS IN THE OLDER POPULATION AGED 65 AND OLDER. DUE TO SUCH HIGH PREVALENCE, THIS STUDY AIMED TO PROVIDE THE INCIDENCE RATE OF THESE CANCERS IN SUCH POPULATION AND OBSERVE THE CHANGING IMPACT OF THESE CANCERS WITH INCREASING AGE VERSUS YOUNG ADULT (15 TO 44) AND MIDDLE AGE (45 TO 64) GROUPS...

INTRODUCTION: CRC RESULTS FROM A PROGRESSIVE ACCUMULATION OF GENETIC AND EPIGENETIC ALTERATIONS THAT LEAD TO UNCONTROLLED GROWTH OF CELLS IN THE COLON AND RECTUM. CELL SURFACE GROWTH FACTOR RECEPTORS PLAY A VITAL ROLE. RON RECEPTOR TYROSINE KINASE, ONE OF THESE RECEPTOR, IS ACTIVATED BY BINDING OF ITS LIGAND, HGFL. THE OVEREXPRESSION OF RON HAVE DOCUMENTED IN A VARIETY OF HUMAN CANCERS INCLUDING BREAST, COLON, LIVER, PANCREAS, AND BLADDER. THE AIM OF THIS STUDY WAS TO REVEAL MISREGULATION OF RON IN CRC TISSUES COMPARE TO NORMAL ADJACENT TISSUE...

INTRODUCTION & AIM: POLYMERS ARE WIDELY USED AS BIOMATERIALS DUE TO THEIR FAVORABLE PROPERTIES. ESPECIALLY IN THE FIELD OF TARGETED DRUG DELIVERY, POLYMER PLAYED A SIGNIFICANT ROLE BECAUSE IT CAN DELIVER THERAPEUTIC AGENTS DIRECTLY INTO THE INTENDED SITE OF ACTION, WITH SUPERIOR EFFICACY...

INTRODUCTION AND AIM: COMPARED TO OTHER CANCERS, THE GASTROINTESTINAL ONES ARE WORSE IN PROGNOSIS AND 5-YEAR SURVIVAL RATE. THESE CANCERS HAVE NOT A SPECIFIC TREATMENT AND ARE NOT PREDETERMINED, BUT SEEM TO BE MANAGEABLE BY AWARENESS OF PREVENTIVE MEASURES. THE NUTRITION IS CONSIDERED AS THE MAIN ENVIRONMENTAL FACTOR IN PATHOGENESIS OF 35% OF CANCERS. THE PURPOSE OF THIS STUDY WAS TO COMPARE THE EATING HABITS BETWEEN HEALTHY PEOPLE AND PATIENTS WITH GASTROINTESTINAL CANCERS...

INTRODUCTION AND AIM: GASTROINTESTINAL MALIGNANCIES ARE OF THE MOST COMMON CANCERS AND ACCOUNT FOR HALF OF ALL CANCER RELATED MORTALITIES IN IRANIAN POPULATION. THERE WAS STRONGEST ASSOCIATION BETWEEN HUMAN PAPILLOMAVIRUS (HPV) INFECTION AND UROGENITAL CANCERS IN PARTICULAR CERVIX. HOWEVER THERE IS NO CLEAR CAUSAL RELATIONSHIP IN ALL TYPES OF CANCERS, INCLUDING GASTROINTESTINAL CANCERS. THEREFORE PRESENT STUDY AS A SYSTEMATIC REVIEW AND META-ANALYSIS WAS DESIGNED TO EVALUATE THE PREVALENCE OF HPV IN GASTROINTESTINAL CANCERS AND ITS RELATION WITH THESE CANCERS...

INTRODUCTION & AIM: THE RHOB GENE IS ONE OF THE GENES THAT ARE INVOLVED IN WITH CANCERS SUCH AS GASTRIC CANCER. THIS GENE IS CONTRIBUTED IN CYTOSKELETAL ORGANIZATION AND CELL TRAFFICKING AND ITS EXPRESSION IS DECREASED IN GASTRIC CANCER. THERE ARE A VNTR POLYMORPHISM IN THE PROMOTER OF THE RHOB GENE AND IN THIS STUDY DIFFERENT GENOTYPES OF THIS VNTR IS ASSESSED WITH RISK OF GASTRIC CANCER, FOR THE FIRST TIME...

LEIOMYOSARCOMA IS A MALIGNANT TUMOR OF MESENCHYMAL CELLS AND IS THE MOST COMMON SOFT TISSUE SARCOMA. LEIOMYOSARCOMA IS AN EXTREMELY RARE TUMOR IN OCULAR AND PERIOCULAR REGION AND CAN BE PRIMARY, SECONDARY OR METASTATIC. PRIOR TO THE ADVENT OF C-KIT IMMUNOREACTIVITY, THE MAJORITY OF GASTROINTESTINAL STROMAL TUMORS WERE CLASSIFIED AS LEIOMYOSARCOMA...

INTRODUCTION: MOST STOMACH CANCERS ARE ADENOCARCINOMAS TYPE. USUALLY AFFECTS THE LOWER AND MIDDLE STOMACH. REMOVAL OF GASTRIC CARCINOMA IS ONLY POSSIBLE IF THE CANCER HAS NOT SPREAD TO THE STOMACH AND IS LIMITED. THE AIM OF THIS STUDY IS NURSING CARE AFTER SURGERY FOR GASTRIC CANCER...

INTRODUCTION & AIM: HELICOBACTER PYLORI INFECTION IS ONE OF THE MAIN RISK DETERMINANTS OF GASTRIC NON-CARDIA CANCER (GNCC), WHILE GASTRIC CARDIA CANCER (GCC) HAS NEGATIVE, POSITIVE OR NO ASSOCIATION WITH H. PYLORI INFECTION. ARDABIL HAS THE HIGHEST RATES OF H. PYLORI INFECTION (89%) IN IRAN AND ONE OF THE HIGHEST GCC RATES IN THE WORLD. THE AIM OF PRESENT STUDY WAS TO ANALYZE THE ASSOCIATIONS OF H. PYLORI INFECTION, AGE AND GENDER AND AREA OF RESIDENCE WITH THE RISK OF BOTH THE TYPE OF GC IN THE ARDABIL...

INTRODUCTION: SINCE CANCER IS THE MOST COMMON CAUSE OF DEATH IN THE WORLD POPULATION, THE POSSIBILITY THAT READILY AVAILABLE NATURAL SUBSTANCES FROM PLANTS, VEGETABLES, HERBS, AND SPICES MAY BE BENEFICIAL IN THE PREVENTION OF CANCER WARRANTS CLOSER EXAMINATION.SAFFRON IS A SPICE DERIVED FROM THE FLOWER OF THE SAFFRON CROCUS (CROCUS SATIVUS) PLANT NATIVE TO SOUTHWEST ASIA. IT HAS HISTORICALLY BEEN THE WORLD’S MOST EXPENSIVE SPICE PER UNIT WEIGHT. CHEMICAL ANALYSIS HAS SHOWN THE PRESENCE OF MORE THAN 150 COMPONENTS IN SAFFRON STIGMAS. THE MORE POWERFUL COMPONENTS OF SAFFRON ARE CROCIN, CROCETIN AND SAFRANAL. STUDIES IN ANIMAL MODELS AND WITH CULTURED HUMAN MALIGNANT CELL LINES HAVE DEMONSTRATED ANTITUMOR AND CANCER PREVENTIVE ACTIVITIES OF SAFFRON AND ITS MAIN INGREDIENTS, POSSIBLE MECHANISMS FOR THESE ACTIVITIES ARE DISCUSSED...

INTRODUCTION & AIM: CIRCULATING MICRORNAS ARE PROMISING BIOMARKERS IN DIAGNOSIS AND ASSESSMENT OF CANCEROUS PATIENTS. QUANTITATIVE REAL-TIME PCR ASSAY IS A SENSITIVE TEST FOR EVALUATING THE LEVELS OF MIRNAS EXPRESSION. NEVERTHELESS, THERE IS NO CONCURRENCE ON SELECTING APPROPRIATE REFERENCE GENES FOR QPCR ANALYSIS OF MIRNAS IN CIRCULATION. THEREFORE, THE CURRENT STUDY AIMED TO SELECT A SUITABLE REFERENCE GENE FOR NORMALIZING THE RT-QPCR ASSAY RESULTS IN PLASMA SAMPLES OF PATIENTS WITH GASTRIC CANCER...

MONITORING CANCER INCIDENCE AND TIME TRENDS IS ESSENTIAL FOR CANCER RESEARCHES AND HEALTH CARE PLANNING. IN SERVICE PLANNING, INDICATORS SUCH AS INCIDENCE CAN HELP DEVELOPMENT OF STRATEGIES FOR SERVICE PROVIDERS. IT IS ESTABLISHED FIGURE OF CANCER INCIDENCE WILL RISE IN FUTURE AND A MAJOR PART OF SUCH RISE ACCURSE IN DEVELOPING COUNTRIES WHERE 70% OF CANCERS RELATED DEATH WILL OCCUR. IT IS NECESSARY TO PROVIDE A CLEAR COMPARABLE FIGURE OF TRENDS IN INCIDENCE OF GI CANCERS IN IRAN. INCIDENCE DATA WAS PROVIDED BY CANCER REGISTRY SYSTEM SUPERVISED BY MOHME. THE DATA WAS ANALYZED BY EACH GI SEPARATED OVER 5 YEARS...

INTRODUCTION & AIM: WORLDWIDE, COLORECTAL CANCER (CRC) IS REPORTED TO BE THE FOURTH MOST COMMON CANCER IN MEN AND THE THIRD MOST COMMON IN WOMEN. KRAS IS A PROTOONCOGENE LOCATED ON THE SHORT ARM OF CHROMOSOME 12. THE AIM OF THIS STUDY WAS TO EVALUATE THE KRAS ONCOGENE AND ITS RELATIONSHIP IT WITH CLINICOPATHOLOGIC FEATURES IN 33 KURDISH PATIENTS...

INTRODUCTION AND AIMS: THE PRESENT INVESTIGATION WAS DESIGNED TO ASSESS THE EXPRESSION LEVELS OF DCLK1 AS A DISTINGUISHED INTESTINAL CANCER STEM CELL MARKER IN GASTRIC MALIGNANCY AND ITS CLINICAL SIGNIFICANCE IN A SERIES OF GASTRIC CANCERS (GC)...

INTRODUCTION & AIM: INCIDENCE OF COLORECTAL CANCER (CRC) IN IRAN HAS INCREASED RECENTLY; ESPECIALLY THE INCIDENCE OF THE DISEASE IN YOUNG PATIENTS IS HIGHER THAN EXPECTED. AIM OF THIS STUDY IS SURVEY ON 40 YOUNG PATIENTS WITH CRC IN KURDISH POPULATION...

A. IN RESECTABLE PANCREATIC ADENOCARCINOMAS:1. AFTER RESECTION MOST PATIENTS WILL BENEFIT FROM ADJUVANT CHEMOTHERAPY. 2. AFTER ADJUVANT CHEMOTHERAPY ADDING CHEMORADIATION IS CONTROVERSIAL – BETTER IN R1 OR N1 TUMORS.3. NEOADJUVANT TREATMENT IN RESECTABLE TUMORS MAY ADD SOME BENEFIT BUT IS STILL INVESTIGATIONAL. 4. PATIENTS WITH RESECTABLE TUMORS BUT WORSE PROGNOSIS MAY BE CANDIDATES FOR NEOADJUVANT TREATMENT...

INTRODUCTION: PANCREATIC CANCER IS THE FOURTH LEADING CAUSE OF CANCER-RELATED VESSEL. RISK FACTORS FOR PANCREATIC CANCER INCLUDE CONTACT MATERIALS, HIGH-FAT DIET WITH HIGH MEAT AND ENVIRONMENTAL TOXINS. PANCREATIC CANCER AND CHRONIC PANCREATITIS ASSOCIATED WITH DIABETES MELLITUS AND INHERITANCE...

INTRODUCTION: GASTRIC CANCER IS THE SECOND MOST COMMON CANCER IN ASIA. BECAUSE MORE THAN 50 PERCENT OF KNOWN CASES DIAGNOSIS IS INOPERABLE. DESPITE AVAILABLE TREATMENTS HAVE A HIGH CHANCE OF A LIFETIME 5-YEAR-OLD CAN NOT EXPECT THESE PEOPLE. SINCE THE PREVALENCE OF GASTRIC CANCER, THE PRESENCE OF APPROPRIATE TOOLS FOR EARLY DETECTION AND TREATMENT, THIS STUDY WAS CONDUCTED TO DETERMINE THE DIAGNOSIS AND TREATMENT OF GASTRIC CANCER...

TO EXPLORE THE CYTOTOXICITY EFFECTS OF CASPIAN COBRA (NAJA OXIANA OR N. OXIANA) VENOM ON HEPATOCYTES AND MITOCHONDRIA OBTAINED FROM THE LIVER OF HCC RATS. IN THIS STUDY, HCC INDUCED BY DIETHYLNITROSAMINE (DEN), AS AN INITIATOR, AND 2-ACETYLAMINOFLUORENE (2-AAF), AS A PROMOTER...

INTRODUCTION & AIM: COLORECTAL CANCER (CRC) IS THE THIRD MOST COMMON CANCER, AND THE FOURTH MOST COMMON CAUSE OF CANCER DEATH WORLDWIDE. APPROXIMATELY, 1.4 MILLION PEOPLE ARE DIAGNOSED WITH CRC AND 700, 000 DIE OF CRC ANNUALLY.THE ABILITY OF CANCER CELLS TO MIGRATE AND RELOCATE LEAD TO THE CREATION OF SECONDARY TUMORS ELSEWHERE IN THE BODY.COFILIN 1 IS ONE OF THE IMPORTANT PROTEINS RESPONSIBLE FOR CELL MIGRATION PROCESS AND PLAYS A KEY ROLE IN THE DYNAMICS OF ACTIN FILAMENTS. MICROTUBULE ACTINS ARE RESPONSIBLE FOR FORMING CELLS. THEY ARE ALSO ESSENTIAL IN CYTOKINESIS AND CELL MIGRATION BY CREATING REDUNDANCIES AND FALSE LEGS. COFILIN 1 IS CONSIDERED AS AN ACTIN-BINDING PROTEIN WHICH CONTROLS LOCATING, POLYMERIZATION AND DEPOLYMERIZATIONOF ACTIN MONOMERS. THE PURPOSE OF THIS STUDY, AS A CASE-CONTROL STUDY, WAS TO EXAMINE CHANGES IN COFILIN 1 GENE EXPRESSION IN PATIENTS WITH COLORECTAL CANCER...

INTRODUCTION: GASTRIC CANCER (GC) HAS A HIGH INCIDENCE AND RANKS SECOND IN THE LEADING CAUSES OF CANCER RELATED DEATH. DESPITE MANY ADVANCES IN TREATMENT OF GC, PATIENTS SHOW POOR PROGNOSIS AND THE 5-YEAR SURVIVAL RATE IS 5–20% AND>80% OF CASES ARE DIAGNOSED AT THE MIDDLE TO LATE DISEASE STAGE. THEREFORE, IDENTIFYING NOVEL BIOMARKERS OPEN NEW LANDSCAPES IN DIAGNOSIS AND PROGNOSIS FOR VARIOUS STAGES OF GC.TODAY, THE EXISTING CANCER BIOMARKERS SUCH AS MG7-AG, CEA, CA199 AND CA50 IN CLINICAL DIAGNOSIS CANNOT BE EFFECTIVELY APPLIED TO THE CLINICAL DIAGNOSIS OF GC BECAUSE OF THEIR LOW SENSITIVITY AND SPECIFICITY...

INTRODUCTION AND AIM: LARGE BOWEL PREPARATION BEFORE SURGERY IS ONE OF ISSUES WHICH HAVE BEEN ADDRESSED IN RECENT YEARS. ACCORDING TO LAST REPORTS, THIS METHOD MAY LEADS TO INCREASE RISK OF WOUND INFECTION AND LEAK OF ANASTOMOSIS. THE SUBJECT WHICH HAS DEALT LESS IS SURGEON’S CONVENIENCE DURING SURGERY AND POSSIBILITY OF BOWEL PERFORATION...

CANCER IS BELIEVED TO BE A DISEASE INVOLVING STEM CELLS. THE DIGESTIVE TRACT HAS A VERY HIGH CANCER PREVALENCE PARTLY OWING TO RAPID EPITHELIAL CELL TURNOVER AND EXPOSURE TO DIETARY TOXINS. WORK ON THE HEREDITARY CANCER SYNDROMES INCLUDING FAMALIAL ADENOMATOUS POLYPOSIS (FAP) HAS LED TO SIGNIFICANT ADVANCES, INCLUDING THE ADENOMACARCINOMA SEQUENCE. THE INITIAL MUTATION INVOLVED IN THIS STEPWISE PROGRESSION IS IN THE “GATEKEEPER” TUMOR SUPPRESSOR GENE ADENOMATOUS POLYPOSIS COLI (APC). IN FAP SOMATIC, SECOND HITS IN THIS GENE ARE NONRANDOM EVENTS, SELECTED FOR BY THE POSITION OF THE GERMLINE MUTATION...

INTRODUCTION: COLORECTAL CANCER REFERS TO SEVERAL TYPES OF CANCER THAT CAN BE SEEN IN THE COLON OR RECTUM. IN THIS DISEASE, ABNORMAL GROWTH OF CELLS IN THE LOWER GASTROINTESTINAL TRACT AND BECOME METASTATIC. SIGNS AND SYMPTOMS OF CANCER OR METASTASIS BASED ON THE LOCATION OF TUMORS IN THE INTESTINE DIFFERS. UNFORTUNATELY, ALL OF COLORECTAL CANCER DETECTION METHODS ARE INVASIVE, PAINFUL AND EMBARRASSING. THE AIM OF THIS STUDY IS TO EVALUATE MUTATIONS IN K-RAS AND APC GENE IN PATIENTS WITH COLORECTAL CANCER WITH NON-INVASIVE METHOD USING STOOL SAMPLES...

INTRODUCTION AND AIM: A POUCH-LIKE TUBE KNOWN AS APPENDIX THAT IS ATTACHED TO CECUM MAY BE A PART OF THE LYMPHATIC, EXOCRINE, OR ENDOCRINE SYSTEMS. TUMORS THAT OCCUR IN THIS SMALL ORGAN OF DIGESTIVE TRACT COMPRISE A LARGE GROUP OF BOTH BENIGN AND MALIGNANT DISEASES INCLUDING CARCINOID, APPENDICAL MUCOCELES, COLONIC-TYPE ADENOCARCINOMA, ETC. CONSIDERING THE IMPORTANCE OF EPIDEMIOLOGICAL INFORMATION FOR EARLY DETECTION, PREVENTION AND CONTROL OF THE DISEASES, DIFFERENT TYPES OF APPENDIX TUMORS WAS EVALUATED IN BAQIYATALLAH HOSPITAL...

INTRODUCTION & AIM: GASTRIC CANCER (GC) IS THE FIFTH COMMONEST MALIGNANT DISEASE AND THE THIRD-LEADING CAUSE OF CANCER-RELATED MORTALITY IN THE WORLD. ARDABIL, A NORTHWESTERN PROVINCE OF IRAN, INCLUDES THE HIGHEST RATE OF GC WITHIN THE COUNTRY. THE AIM OF THE PRESENT STUDY WAS TO ASSESS THE ASSOCIATIONS OF THE VACA C-REGION GENOTYPES OF HELICOBACTER PYLORI WITH GC IN THE ARDABIL POPULATION...

INTRODUCTION & AIM: GASTRIC CANCER IS A SERIOUS HEALTH PROBLEM AND THE SECOND MOST COMMON TYPE OF FATAL CANCER IN THE WORLD THAT IS ASSOCIATED WITH POOR SURVIVAL RATES.GASTRIC CANCER IS INFLUENCED BY GENETIC AND ENVIRONMENTAL FACTORS. SEVERAL GENES MAY BE ASSOCIATED WITH AN INCREASED RISK OF GASTRIC CANCER. THE PURPOSE OF THIS STUDY WAS AN OVERVIEW OF THE GENES INVOLVED IN GASTRIC CANCER...

INTRODUCTION: CANCER STEM CELLS (CSCS) ARE SUBPOPULATION OF TUMOR CELLS THAT CAUSE RELAPSE AND METASTASIS BY GIVING RISE TO NEW TUMORS. THUS IT IS IMPORTANT TO KNOW THE MECHANISMS THAT REGULATE SELF-RENEWAL AND DIFFERENTIATION OF CSCS. ALSO IT HAS BEEN DEMONSTRATED THAT CSCS ARE THE CAUSE OF CHEMOTHERAPY RESISTANCE. SO THE STUDY OF THE PROPERTIES OF STEM CELLS COULD BE A NEW WINDOW OF OPPORTUNITY TO INCREASE SURVIVAL IN PATIENTS AND CREATE MORE EFFECTIVE TREATMENTS IN THE FUTURE. THE AIM OF THIS REPORT IS TO SUMMARIZE STUDIES OF CSCS AND TUMOR METASTASIS AT THE CELLULAR LEVEL, WITH OBTAIN OF NEW INSIGHTS INTO UNDERSTANDING THE ROLE OF CSCS IN TUMOR RECURRENCE AND METASTASIS IN COLORECTAL CANCER...

METASTATIC DISEASE TO THE LIVER FROM COLORECTAL CANCER WILL BE PUT INTO CONTEXT IN TERMS OF EPIDEMIOLOGY AND CLINICAL RELEVANCE. THE CONCEPT OF RESECTABLE METASTATIC DISEASE TO THE LIVER WILL BE DISCUSSED...

INTRODUCTION AND AIM: CANCER IS ONE OF THE THREE MAIN PROBLEMS OF THE POPULATION' S HEALTH AND GASTROINTESTINAL CANCERS ARE THE MOST COMMON CAUSE OF CANCER-RELATED DEATHS. ALTHOUGH THE PREVENTIVE RECOMMENDATIONS FOR GI CANCERS ARE ABUNDANT, RELIABLE AND CLEAR, THE INCIDENCE OF GI CANCERS CAUSED BY INCORRECT LIFE STYLE HAS BEEN INCREASED. THE GOAL OF THIS STUDY WAS TO ASSESS PEOPLE'S TENDENCY TO FOLLOW SUCH PREVENTIVE FEEDING BEHAVIORS...

BACK GROUND: ALCOHOL IS A DRUG COLORLESS LIQUID WITH A SWEET SMELL AND TASTE OF BURNING. PEOPLE WITH PSYCHOLOGICAL DEPENDENCE (PHYSICAL) AND MENTAL ALCOHOL IS CALLED ALCOHOLISM. ALCOHOL CAUSES OF CHRONIC DISEASE IN CADENCE PROBLEM INTERPERSONAL AND FAMILY PROBLEMS AND WORK IS. THE EFFECTS OF ALCOHOL CAN BE INTENSIFY THE OFFENSIVE AND AGGRESSION, STUMBLE, TOGETHER AND TALK TO EACH OTHER, HEARTBURN, STRABISMUS, CONFUSION NUMBNESS OF BODY, INCREASED URINATION NOTED. AFTER ALCOHOL ABOUT 20 PERCENT OF IT ABSORBED FROM THE STOMACH AND PROCEDURES AND THE REMAINING 80PERCENT IN THE SMALL INTESTINE WILL BE ABSORBED IN TO THE BODY AND THE KIDNEYS, WHICH IS 5PERCENT URINE IS THE BODY IS REMOVED FROM THE BODY, THOUGH THE LUNGS EXHALE OUT 5 PERCENT AND SMALL AMOUNT OF SWEAT AND MUCH ALCOHOL LIVER ENZYMES OXIDE AND ACETICACID CARBON DIOXIDE AND WATR BECOMES...

INTRODUCTION & AIM: AFTER CARDIOVASCULAR DISEASES AND ACCIDENTS, CANCER IS THE THIRD CAUSE OF DEATH IN IRAN. THE PRESENT STUDY IS AIMED TO INVESTIGATE THE DIGESTIVE CANCER DEATHS, PROCEDURE IN NEYSHABUR AND FIRUZEH DURING 2011-2015...

INTRODUCTION & AIM: COLORECTAL CANCER IS A COMMON MALIGNANCY AND SECOND LEADING CAUSE OF CANCER MORTALITIES IN UNITED STATES AND OTHER DEVELOPED COUNTRIES. THE EFFICIENCY OF RADIATION THERAPY IN THIS TUMOR CELLS IS MODERATE. TO INCREASE THE RESPONSE OF CELLS TO RADIATION, RADIOSENSITIZER CAN BE EMPLOYED. THE AIM OF PRESENT STUDY WAS TO EVALUATE RADIOSENSITIZING EFFECT OF ELECTROPORATION ON INTESTINAL COLON CANCER (HT-29) CELLS AS LESS RADIOSENSITIVE TUMOR CELLS...

INTRODUCTION AND AIM: CAPECITABINE IS CURRENTLY BEING EVALUATED FOR THE TREATMENT OF A VARIETY OF GASTROINTESTINAL MALIGNANCIES. THE AIM OF THIS STUDY IS TO REPORT ON THE INCIDENCE OF LATE GASTROINTESTINAL BLEEDING IN PATIENTS WITH PANCREATIC CANCER WHO RECEIVED CONCURRENT CAPECITABINE AND ABDOMINAL IRRADIATION FOLLOWED BY PROLONGED CAPECITABINE THERAPY...

INTRODUCTION & AIM: COLORECTAL CANCER IS THE THIRD MOST PREVALENT CANCER WORLDWIDE. IT IS DUE TO THE ABNORMAL GROWTH OF COLON OR RECTUM CELLS THAT HAVE THE ABILITY TO INVADE OR SPREAD TO OTHER PARTS OF THE BODY. COLORECTAL CANCER IS INFLUENCED BY GENETIC AND ENVIRONMENTAL FACTORS. MUTATIONS IN THE APC GENE ARE THE MOST COMMON MUTATION FOUND IN COLORECTAL CANCER. THE PURPOSE OF THIS STUDY WAS TO REVIEW OF THE ROLE OF THE APC GENE INVOLVED IN COLORECTAL CANCER...

QUALITY OF LIFE IS A MULTIDIMENSIONAL FEATURES THAT THE WORLD HEALTH ORGANIZATION, IT IS UNDERSTOOD ANY PERSON OF LIFE, VALUES, GOALS, AND INDIVIDUAL INTERESTS HAS DEFINED STANDARDS. THERE IS A RECIPROCAL RELATIONSHIP BETWEEN THE DISEASE AND QUALITY OF LIFE. PHYSICAL DISORDERS AND RELATED SYMPTOMS IN PATIENTS WITH CHRONIC DISEASES SUCH AS CANCER HAVE A DIRECT EFFECT ON ALL ASPECTS OF THE QUALITY OF LIFE OF PATIENTS...

INTRODUCTION: GASTRIC CANCER IS THE SECOND REASON OF CANCER-RELATED DEATH IN THE WORLD WITH PARTICULARLY HIGH PREVALENCE IN EAST ASIA. BASED ON CANCER STEM CELLS (CSCS), MALFUNCTION OF SIGNALING PATHWAYS THAT ARE ESSENTIAL FOR NORMAL GROWTH AND DEVELOPMENT ALSO INVOLVED IN THE TUMOR INITIATION AND PROGRESSION...

INTRODUCTION & AIM: MOST PATIENTS WITH ADVANCED ESOPHAGEAL CANCER HAVE DYSPHAGIA, WHICH LEADS TO WEIGHT LOSS AND MALNOURISHMENT. IN THIS ARTICLE, WE REVIEWED THE USE OF STENTS FOR DYSPHAGIA PALLIATION IN THESE PATIENTS...

RECOMMENDATIONS ON NEOADJUVANT TREATMENT FOR ALL STAGE IIA AND III RECTAL CANCER PATIENTS ARE STILL PRESENT IN MOST TREATMENT GUIDELINES FOR RECTAL CANCER MANAGEMENT.BUT IS THERE A NEED FOR THAT? WHAT HAVE WE ACHIEVED SO FAR WITH THE INTRODUCTION OF NEOADJUVANT RT IN TERMS OF LOCAL CONTROL AND RADIATION INDUZED SIDE EFFECTS?

BACKGROUND: IT IS NECESSARY TO KNOW THE CAUSES OF DYSPEPSIA TO ESTABLISH THE THERAPEUTIC APPROACH. DYSPEPSIA IS A FREQUENT SYNDROME OUR COUNTRY, WHILE THERE ARE RESTRICTIONS TO ENDOSCOPY AND HIGH PREVALENCE OF HELICOBACTER PYLORI (H. PYLORI) INFECTION. THE AIM OF THIS STUDY WAS TO EVALUATE THE ENDOSCOPIC FINDINGS OF THE SYNDROME, IN AN OUTPATIENT SCREENING CLINIC OF THE BAQIYATALLAH HOSPITAL IN TEHRAN, IRAN...

INTRODUCTION & AIM: COLORECTAL CANCER (CRC) IS THE THIRD MOST PREVALENT CANCER WORLDWIDE. THE INCREASING INCIDENCE OF COLORECTAL CANCER (CRC) IN THE PAST THREE DECADES IN IRAN HAS MADE IT A MAJOR PUBLIC HEALTH BURDEN. THE PURPOSE OF THIS STUDY WAS TO COMPARE PARAMETRIC COMPETING RISK AND COX MODELS AS WELL AS TO DETERMINE DEMOGRAPHIC AND PATHOLOGICAL FACTORS AFFECTING THE SURVIVAL OF PATIENTS WITH COLORECTAL CANCER...

COLORECTAL CANCER (CRC) IS THE THIRD MOST COMMON CANCER IN THE WORLD. THIS DISEASE IS THE FORTH MOST COMMON CANCER IN IRANIAN MEN AND THE SECOND AMONG WOMEN. CRC HAS BECOME ONE OF THE DEADLIEST AND ALSO ONE OF THE MOST AVOIDABLE CANCERS. COLORECTAL CANCER DEATH RATES HAVE BEEN DECLINED IN DEVELOPED COUNTRIES PROBABLY DUE TO INCREASED USE OF AVAILABLE SCREENING TESTS AS WELL AS ENCOURAGING A HEALTHFUL DIET AND EXERCISE...

BACKGROUND AND AIM: ACCORDING TO WORLD HEALTH ORGANIZATION (WHO) MOST OF CHRONIC DISEASES SUCH CANCER, CAN BE PREVENTIVE BY IDENTIFYING RISK FACTORS LIKE UNHEALTHY DIET, SMOKING AND LACK OF PHYSICAL ACTIVITY. THESE FACTORS ARE DUE TO UNHEALTHY LIFE STYLE, AND IT IS NECESSARY TO DECREASE THEM BY EDUCATIONAL INTERVENTIONS. THE AIM OF CURRENT STUDY WAS DETERMINING THE EFFECTIVENESS OF EDUCATIONAL INTERVENTION BASED ON HEALTH BELIEF MODEL (HBM) ON NUTRITIONAL PREVENTIVE BEHAVIORS FROM COLORECTAL CANCER AMONG STAFF OF SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES' FACULTIES...