The aim of this study was to investigate the effectiveness of quality of life psychotherapy on blind girls’ mental health in Esfahan. The study was quasi-experimental with pretest, posttest, control group design and a follow up. The population consisted of all blind girls who had records in Isfahan Welfare Organization in 2014. Through convenience sampling, 40 blind girls were selected and randomly assigned into two groups, experimental and control. Experimental group received quality of life psychotherapy for 8 sessions (90 minutes each) and then, both groups completed SCL-90-R personality traits questionnaire (Dragotis et al, 1973). The data were analyzed by analysis of covariance. Time-varying effects of depression were significant, that is, the pre-test rate of depression in both groups decreased significantly (P<0.01). The interaction of time with the indicators of anxiety, obsession and hostility was significant (P<0.01). In other words, psychotherapy made a significant difference between experimental group and control group in the three indicators of anxiety, obsession and hostility in posttest and follow up.