The purpose of this study was to predict the tendency of high risk behaviors based on religious beliefs, emotion seeking, environmental polution and media in female university students. The population included all female students at the University of Isfahan. Thus, in a correlational research design, 290 students were randomly selected and were assessed by Iranian Adolescents Risk Taking Scale (IADS), the Questionnaire for Measurement Rate of Use of Media (elyasi, 1393), Emotion Seeking Scale (Zukerman), Questionnaire of Religious Beliefs (Keshavarz & et al., 1389), a researcher-made scale for environmental pollution, and the Demographic Questionnaire. Results of Pearson correlation showed that religious beliefs, emotion seeking, squalor milieu, age of testees had significant relationship with high risk behaviors. In addition results of hierarchical regression showed that from among first rank variables, doing the religious rituals, uninhibition, squalor milieu, the use of virtual and social network; and from among second rank variables parents age can predict 54.9 % of tendency to high risk behaviors in female students (p<0.01).