In this paper, a natural cooling system composed of domed roof and solar adsorption chiller is presented and its performance to provide the thermal comfort conditions in Yazd, Kerman, and Tehran is investigated based on ISIRI 14384 and ISO 7730. Furthermore, the effects of environmental parameters, wind speed, and geometric characteristics on the system performance are studied. To calculate the number of air changes of the room, Ansys Fluent software is used. Additionally, to estimate the room inlet temperature, the governing equations of the adsorption chiller and cooling channel are solved based on the fourth order Runge-Kutta and finite difference methods, respectively. The results show that increasing the incision diameter of the domed roof as well as the width of the cooling channel causes the number of air changes of the room to increase. Alternatively, increasing the width of the inlet air vent up to a threshold value will cause the number of air changes to increase. However, increasing beyond the threshold value has no significant effect on the number of air changes. Additionally, in the aforementioned cities, the room inlet air temperature is almost constant when the chiller operates. Finally, the environmental conditions for which the system is able to provide thermal comfort conditions, in the test room on July 15, are determined.