Introduction: Suicide is one of the social and health challenges, which has influenced on the individual, family, and society. Statistics reveal that suicide rates have increased in the country. The present research carried out to determine the incidence of suicide in Iran through meta-analysis and systematic review.Methods: This is a systematic review and meta-analysis study on suicide incidence and trend in Iran by reviewing published papers within 2001-2014. To do this, databases including Medlib, Google Scholar, Pubmed, ISI, Science direct, SID, Medline, Magiran, and Irandoc were searched and two trained researchers independently extracted the articles through keywords and combinations. The results were integrated through using weighted average and Poisson distribution.Results: In the preliminary searching, 30 papers of 132 were qualified for study. The rate of suicide was estimated 8 out of one hundred thousand in Iran (1/9–6/8: 95% confidence interval), which was 11.1 (8/6-13/ 8: 95% confidence interval) and 7.4 (5/3–9/5: 95% confidence interval) in males and females, respectively. The results showed that the trend of suicide was descending in the last decade.Conclusion: Incidence of suicide has decreased in Iran during last years; however, the incidence was relatively high in western provinces. As well as The incidence of suicide leading to death among men far more than women.