Pistachio is one of the most important nut crops that has a special place among agricultural products. In recent years, the rate of yield production in Iran was less than that of global amounts, which the plant nutritional problems are of the most important reason for that. Present study was conducted to evaluate the effect of foliar spray with amino acids and seaweed extract on yield and quality of pistachios (cv Ahmad Aghaei). The experiment was carried out as a factorial randomized complete block design with three replications. Treatments was spraying with amino acids (aminosauren) and seaweed (Ascophyllum nodosum), both at three levels (0, 1 and 2 mg/L). Among the treatments, aminosuren had more positive effects on the yield of pistachio, than the algae extract of Ascophyllum. Different concentrations of amino acids and seaweed extracts showed significant effects on leaf area and pistachio yield compared with the control samples. Based on the results, combination treatment of aminosauren and seaweed at a concentration of 2 mg/L had the best effect on yield (4. 58 kg/tree), leaf area (109/8 cm2) and nut weigh (18. 8 ounces). Finally, according to the results of this study, the combined fertilizer containing amino acids and seaweed can play a significant role in improving the yield and quality attributes of pistachio.