Background & Aims: Diabetes is the most common metabolic disease in the world, and self-care is one of the main strategies for controlling the disease. Several studies point to the lack of optimal self-care in diabetic patients as psychological barriers, and emotional distress seems to be one of the factors affecting it. Therefore, this study was conducted to determine the relationship between self-care and emotional distress in patients with type 2 diabetes. Materials & Methods: In this descriptive cross-sectional study, 380 patients with type 2 diabetes were selected from among those referring to Yazd Diabetes Research Center in 2018. A demographic questionnaire, an emotional distress questionnaire, and a self-care questionnaire for diabetic patients were utilized for gathering data. The collected data were analyzed by SPSS software version 21, and descriptive statistics and Pearson correlation coefficient were utilized. Results: The results showed that the mean score of self-care patients was 56. 65 ± 13. 13 and the mean score of emotional distress was 40. 82 ± 15. 15. Therefore, self-care and emotional distress were moderate in most patients. Based on the Pearson correlation coefficient, there was a negative correlation between self-care score and emotional distress in diabetic patients (r =-0. 25, p = 0. 01). Conclusion: Reducing emotional distress is one of the factors affecting the improvement of patients' self-care behaviors, therefore it is necessary to pay attention to it in educational and counseling programs to prevent complications of diabetes and to increase the self-care behaviors of patients.