Background: The relationship between locus of control and coping strategies is substantially influenced by how a person apprsises it and reacts to it. The recognition of effective factors on reactions to stressful events, have a substantial role in the management and control of stress, and always had been a substantial issues in studies connected to coping behaviorology. Objective: The aim of this study was to determine the difference between individuals with internal and external locus of control, for coping strategies in stressful situations. Method: This study was conducted with survey and cross-sectional method. Data were collected from 373 students of Yazd University, from seven educational groups, between 22 June and 22 July 2006. These Students were selected via sampling. Students then were responded to Standardized Scales: Coping Strategies Scale (CSS) and Multidimensional Health Locus of Control Scale(MHLCS). Results: The results showed significant difference among students with internal and external locus of control, in regard to coping strategies, in generally, and in regard to components of coping strategies: seeking social support, reappraisal/adjustment, avoidance coping, problem-focused
coping, emotion-focused coping, active coping, and self-control, specially. Hierarchical multiple regression analysis showed that the locus of control variable explained for %16.8 of the variance in coping strategies. Discussion: The results of this study have been doubted the previous findings about higher use of problemsolving coping strategies by individuals with internal locus of control, and about the higher use of emotion-focused coping strategies by individuals with internal locus of control.