Background and Objectives: Time pattern for pulmonary thrombo-embolism (PTE) is known, while data on the incidence of deep vein thrombosis (DVT) is not clear. The aim of this study was to determine the seasonal variation in DVT incidence in Rafsanjan city in 2017 Materials and Methods: In this cross-sectional study, all 347 suspected DVTs were examined and diagnosis of DVT was performed by clinical examinations and ultrasonography. Demographic variables and their associated risk factors were recorded and analyzed by descriptive and analytic methods. Results: A total of 317 DVT were detected in the patients. The mean age of these individuals was 18± 52 years old and 57% were male and 42% female. The highest incidence was in the spring (29%) and summer (25%). Conclusion: There was a seasonal pattern of DVT occurrence in Rafsanjan city. Therefore, when an anticoagulant is administered, warmer months and high levels of hypercoagulability can be considered as an additional potential risk.