STUDY OF MTHFR A1298C POLYMORPHISM AS A GENETIC RISK FACTOR FOR CARDIOVASCULAR DISEASE IN THE IRANIAN POPULATION

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HADAVI VALEH; IMANIAN HASHEM; KARIMINEJAD ARIANA; ALMADANI NAVID; ROSTAMI MARYAM; OBERKANINS CHRISTIAN; NAJMABADI HOSSEIN

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Journal: GENETICS IN THE 3RD MILLENNIUM Year:2010 | Volume:8 | Issue:1 Page(s): 1962-1966

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Title

STUDY OF MTHFR A1298C POLYMORPHISM AS A GENETIC RISK FACTOR FOR CARDIOVASCULAR DISEASE IN THE IRANIAN POPULATION

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Keywords

VENOUS THROMBOEMBOLISMQ3

POLYMORPHISMQ3

GENETICQ3

METHYLENETETRAHYDROFOLATE REDUCTASEQ3

GENE FREQUENCYQ2

IRANQ2

Abstract

Two hundred and eight asymptomatic individuals from different origins of IRAN were included in this study in order to assess the distribution of the MTHFR A1298C POLYMORPHISM responding for cardiovascular disease (CVD) in the general IRANian population using a novel technique reverse hybridization StripAssay for the rapid and simultaneous detection. The test is based on multiplex PCR and hybridization to a teststrip presenting a parallel array of allele-specific oligonucleotide probes for each mutation. The prevalence of mutant MTHFRAl298C in our study population (0.42), was remarkably high. Mutant MTHFRAl298C in IRAN occurred less frequently than among Europeans, but exceeded the much lower frequencies known from India and most of Asia. Here we describe the distribution of mutant allele MTHFR A1298C in different ethnicities of IRANian population and compare the results to previously reported data. Our data represent the only comprehensive study to date with respect to thrombophilic gene POLYMORPHISM in IRAN.

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APA: Copy

HADAVI, VALEH, IMANIAN, HASHEM, KARIMINEJAD, ARIANA, ALMADANI, NAVID, ROSTAMI, MARYAM, OBERKANINS, CHRISTIAN, & NAJMABADI, HOSSEIN. (2010). STUDY OF MTHFR A1298C POLYMORPHISM AS A GENETIC RISK FACTOR FOR CARDIOVASCULAR DISEASE IN THE IRANIAN POPULATION. GENETICS IN THE 3RD MILLENNIUM, 8(1), 1962-1966. SID. https://sid.ir/paper/117213/en

Vancouver: Copy

HADAVI VALEH, IMANIAN HASHEM, KARIMINEJAD ARIANA, ALMADANI NAVID, ROSTAMI MARYAM, OBERKANINS CHRISTIAN, NAJMABADI HOSSEIN. STUDY OF MTHFR A1298C POLYMORPHISM AS A GENETIC RISK FACTOR FOR CARDIOVASCULAR DISEASE IN THE IRANIAN POPULATION. GENETICS IN THE 3RD MILLENNIUM[Internet]. 2010;8(1):1962-1966. Available from: https://sid.ir/paper/117213/en

IEEE: Copy

VALEH HADAVI, HASHEM IMANIAN, ARIANA KARIMINEJAD, NAVID ALMADANI, MARYAM ROSTAMI, CHRISTIAN OBERKANINS, and HOSSEIN NAJMABADI, “STUDY OF MTHFR A1298C POLYMORPHISM AS A GENETIC RISK FACTOR FOR CARDIOVASCULAR DISEASE IN THE IRANIAN POPULATION,” GENETICS IN THE 3RD MILLENNIUM, vol. 8, no. 1, pp. 1962–1966, 2010, [Online]. Available: https://sid.ir/paper/117213/en

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