EFFECT OF ISOLATED SOY PROTEIN ON PREVENTION OF RHEUMATOID ARTHRITIS IN COLLAGEN-INDUCED RATS

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MOHAMMAD SHAHI M.; MAHBOUB S.A.; HEYDARI FATEMEH; RASHIDI B.; RASHIDI M.R.

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Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2009 | Volume:3 | Issue:1 Page(s): 1-12

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Title

EFFECT OF ISOLATED SOY PROTEIN ON PREVENTION OF RHEUMATOID ARTHRITIS IN COLLAGEN-INDUCED RATS

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Keywords

SOYBEAN PROTEINSQ3

ARTHRITISQ2

RHEUMATOIDQ3

ISOFLAVONESQ3

Abstract

Background and Objectives: The aim of this study was to investigate the effect of isolated soy protein on prevention of RHEUMATOID ARTHRITIS in collagen-induced rats.Methods: A total of 24 female Sprague-Dawley rats (body weights: 180-200g) were randomly divided into four equal groups including normal; control of RHEUMATOID ARTHRITIS; RHEUMATOID ARTHRITIS + isolated soy protein (7g/kg); RHEUMATOID ARTHRITIS + dexamethasone (1mg/kg).Experimentally RHEUMATOID ARTHRITIS in rats was induced by subcutaneous injection of collagen .. emolsified in Incomplete Frund’s Adjuvant in days 1 and 7. Treatments were gavaged to animals for 30 days, once a day. The severity of RHEUMATOID ARTHRITIS symptoms in paws were daily measured in double blind format by standard method. The statistical comparison between the experimental groups was performed by Independent -samples ttest and One-Way ANOVA using SPSS software.Results: The clinical symptoms of RHEUMATOID ARTHRITIS started from day 17.4±2.4, 20±4 and 14.1±1.9 in isolated soy protein, dexamethasone and control groups, respectively (P<0.05). The severity of clinical symptoms of RHEUMATOID ARTHRITIS on day 30 was 3.84±2.04, 2±1.78 and 6.5±1.76 in isolated soy protein, dexamethasone and control groups, respectively (P<0.05). At the end of the study, the incidence rates of RHEUMATOID ARTHRITIS in isolated soy protein and control groups was %83.33 and %100, respectively. Conclusion: Isolated soy protein decreased the severity of clinical symptoms of RHEUMATOID ARTHRITIS. Therefore, it could be a key factor in prevention and even treatment of RHEUMATOID ARTHRITIS.

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APA: Copy

MOHAMMAD SHAHI, M., MAHBOUB, S.A., HEYDARI, FATEMEH, RASHIDI, B., & RASHIDI, M.R.. (2009). EFFECT OF ISOLATED SOY PROTEIN ON PREVENTION OF RHEUMATOID ARTHRITIS IN COLLAGEN-INDUCED RATS. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 3(1), 1-12. SID. https://sid.ir/paper/132425/en

Vancouver: Copy

MOHAMMAD SHAHI M., MAHBOUB S.A., HEYDARI FATEMEH, RASHIDI B., RASHIDI M.R.. EFFECT OF ISOLATED SOY PROTEIN ON PREVENTION OF RHEUMATOID ARTHRITIS IN COLLAGEN-INDUCED RATS. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2009;3(1):1-12. Available from: https://sid.ir/paper/132425/en

IEEE: Copy

M. MOHAMMAD SHAHI, S.A. MAHBOUB, FATEMEH HEYDARI, B. RASHIDI, and M.R. RASHIDI, “EFFECT OF ISOLATED SOY PROTEIN ON PREVENTION OF RHEUMATOID ARTHRITIS IN COLLAGEN-INDUCED RATS,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 3, no. 1, pp. 1–12, 2009, [Online]. Available: https://sid.ir/paper/132425/en

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