The Effect of Morphine on Growth and Development of Stomach in Balb/c Mouse embryo

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GHORBANI FATEMEH; SADRAIE SEYED HOMAYOON; KAKA GHOLAMREZA

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL Year:2018 | Volume:12 | Issue:7 Page(s): 12-20

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

558

Download:

Cites:

Information Journal Paper

Title

The Effect of Morphine on Growth and Development of Stomach in Balb/c Mouse embryo

Author(s)

GHORBANI FATEMEH | SADRAIE SEYED HOMAYOON | KAKA GHOLAMREZA | Issue Writer Certificate

Keywords

FetusQ2

MorphineQ2

MiceQ2

StomachQ1

MorphometryQ3

Abstract

Background and Objectives: The presence of addicts in the community, not only causes a lot of problems, but also can lead to problems for the next generation. The purpose of this study was to investigate the effects of Morphine on the appearance and histomorphometric changes of the Stomach tissue in Balb/c mouse embryo. Methods: A total of 30 adult Balb/c Mice were randomly divided into five groups: control group (solvent Morphine), experimental 1 and 2 (received Morphine at the doses of 0. 01 and 0. 1mg/ml, respectively, during pregnancy) and experimental 3 and 4 (received Morphine at the doses of 0. 01 and 0. 1mg/ml, respectively, before and during pregnancy). The pregnant Mice were killed on the 20th day of pregnancy, and the embryos were removed. Weight and crown-rump length of the embryos were recorded, and the 5 micron sagittal sections were prepared. After histological processing and hematoxylin-eosin staining, the Stomach tissue, were examined by light microscope and MOTIC software. Results: The mean weight of the embryos in the experimental group 2 significantly increased compared to the control group. The mean crown-rump length significantly decreased in the experimental groups 2 and 4 compared to the control group. The mean thickness of submucosal layer in both keratinized stratified squamous epithelium and simple columnar epithelium of the Stomach significantly increased in the experimental groups 3 and 4 as compared to the control group. Moreover, the mean number of cells in the simple columnar epithelium of the Stomach in experimental group 4 showed a significant increase compared to the control group. Conclusion: The use of low-dose Morphine during pregnancy can lead to an increase in the weight of the Fetus and the placenta, and does not contribute to malformation and serious damage to the Fetus, but high doses of this drug cause histomorphological changes in the thickness of the submucosal layer in both stratified squamous epithelium and simple columnar epithelium of the Stomach.

Cites

No record.

References

No record.

Cite

APA: Copy

GHORBANI, FATEMEH, SADRAIE, SEYED HOMAYOON, & KAKA, GHOLAMREZA. (2018). The Effect of Morphine on Growth and Development of Stomach in Balb/c Mouse embryo. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, 12(7 ), 12-20. SID. https://sid.ir/paper/132445/en

Vancouver: Copy

GHORBANI FATEMEH, SADRAIE SEYED HOMAYOON, KAKA GHOLAMREZA. The Effect of Morphine on Growth and Development of Stomach in Balb/c Mouse embryo. QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL[Internet]. 2018;12(7 ):12-20. Available from: https://sid.ir/paper/132445/en

IEEE: Copy

FATEMEH GHORBANI, SEYED HOMAYOON SADRAIE, and GHOLAMREZA KAKA, “The Effect of Morphine on Growth and Development of Stomach in Balb/c Mouse embryo,” QOM UNIVERSITY OF MEDICAL SCIENCES JOURNAL, vol. 12, no. 7 , pp. 12–20, 2018, [Online]. Available: https://sid.ir/paper/132445/en

Related Journal Papers