THE EFFECT OF SOME FLAVONOIDS ON IN-VITRO NON-ENZYMATIC GLYCOSYLATION OF PROTEINS

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ASGARI SEDIGHEH; NADERI GH.; GHARIPOOR M.

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Paper Information

Journal: Journal of Kermanshah University of Medical Sciences Year:2004 | Volume:8 | Issue:1 Page(s): 1-9

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Information Journal Paper

Title

THE EFFECT OF SOME FLAVONOIDS ON IN-VITRO NON-ENZYMATIC GLYCOSYLATION OF PROTEINS

Author(s)

ASGARI SEDIGHEH | NADERI GH. | GHARIPOOR M. | Issue Writer Certificate

Keywords

FLAVONOIDSQ4

PROTEIN GLYCOSYLATIONQ4

ANTIOXIDANTSQ2

ALBUMINQ2

INSULINQ2

HEMOGLOBINQ3

BIOCHANIN AQ4

Abstract

Introduction: Non-enzymatic glycosylation of proteins which is the major cause of diabetic complications, cardiovascular diseases retinopathy, nephropathy and neuropathy can effectively be inhibited by ANTIOXIDANTS. Materials and Method: The antioxidant effects of several FLAVONOIDS, such as rutin, kaempferol, quercetin, apigenin, naringin, morin and BIOCHANIN A were studied on glycosylation of INSULIN, HEMOGLOBIN and ALBUMINin In-vitro. Optimal glucose concentration as well as incubation time were determined and inhibition percentage of the proteins were measured at three different concentrations (0.5,5 and 10 ?g/ml) using spectrophotometric method. Results: This study showed that BIOCHANIN A has potent antioxicant effects as it inhibits glycosylation of HEMOGLOBIN INSULIN and ALBUMIN by 100%, 60% and 100% respectively. Apigenin is also inhibits ALBUMIN glycosylation by 100%. Conclusion: As potent antioxidant effects are induced by flavenoedes, preventive effects of some plants containing the FLAVONOIDS on diabetic complication is expected.

Cites

IN VITRO EFFECT OF CHAMOMILE, CLOVE AND GARLIC EXTRACT ON NON-ENZYMATIC GLYCOSYLATION OF ALBUMIN

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APA: Copy

ASGARI, SEDIGHEH, NADERI, GH., & GHARIPOOR, M.. (2004). THE EFFECT OF SOME FLAVONOIDS ON IN-VITRO NON-ENZYMATIC GLYCOSYLATION OF PROTEINS. JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD), 8(1), 1-9. SID. https://sid.ir/paper/20920/en

Vancouver: Copy

ASGARI SEDIGHEH, NADERI GH., GHARIPOOR M.. THE EFFECT OF SOME FLAVONOIDS ON IN-VITRO NON-ENZYMATIC GLYCOSYLATION OF PROTEINS. JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD)[Internet]. 2004;8(1):1-9. Available from: https://sid.ir/paper/20920/en

IEEE: Copy

SEDIGHEH ASGARI, GH. NADERI, and M. GHARIPOOR, “THE EFFECT OF SOME FLAVONOIDS ON IN-VITRO NON-ENZYMATIC GLYCOSYLATION OF PROTEINS,” JOURNAL OF KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES (BEHBOOD), vol. 8, no. 1, pp. 1–9, 2004, [Online]. Available: https://sid.ir/paper/20920/en

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