Evaluation of Antioxidant and Cytotoxic Effects of Nanoemulsion of Sour Cherry Kernel Oil on A549 Lung Cancer and HUVEC Normal Cells

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Darchini Maragheh Atieh; HOMAYOUNI TABRIZI MASOUD; KARIMI EHSAN

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Journal: Jundishapur Scientific Medical Journal Year:2019 | Volume:18 | Issue:1 Page(s): 71-79

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Title

Evaluation of Antioxidant and Cytotoxic Effects of Nanoemulsion of Sour Cherry Kernel Oil on A549 Lung Cancer and HUVEC Normal Cells

Author(s)

Darchini Maragheh Atieh | HOMAYOUNI TABRIZI MASOUD | KARIMI EHSAN | Issue Writer Certificate

Keywords

Nano emulsionQ1

Essential oilQ1

Sour cherry coreQ1

AntioxidantQ2

CytotoxicityQ2

Abstract

Background and Objective: Free radicals play a role in the pathology of many diseases, such as cancer, diabetes, heart disease, and especially in the aging process. The use of Antioxidant agents, especially Antioxidants from plant sources, can play a significant role in the prevention and treatment of these diseases. The aim of the present study was to prepare the nanoemulsion formulation of sour cherry kernel oil and to investigate its Antioxidant and cytotoxic effects on normal and cancerous cells. Subjects and Methods: Nanoemulsion was prepared by the use of polysorbate 80 and polysorbate 20 in water as an emulsion of oil in water. Polyethylene glycol was used as the co-surfactant. Antioxidant effects of concentrations of 31. 25, 62. 5, 125, 250, 500 and 1000 μ g/ml of nanomulsion were investigated on DPPH and ABTS radicals and compared with glutathione as standard. In addition, the cytotoxic effects of nanomulsion on A549 cancer cells and normal HUVEC cells were investigated. Results: The Antioxidant results show the potential of nanoemulsion in the removal of radicals of DPPH and ABTS with an IC50 concentration of 412 and 502  g/ml respectively. Furthermore, the results of the Cytotoxicity test showed the greater potency of nanoemulsion on the elimination of cancer cells compared to normal cells (with an IC50 of 52 mg/ml versus 70 mg/ml). Conclusion: Overall, the results of this study indicate the potentially Antioxidant and anti-cancer effects of nanoemulsion of sour cherry kernel oil, which can be used to prevent and treat many diseases that are associated with the production of reactive oxygen species.

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APA: Copy

Darchini Maragheh, Atieh, HOMAYOUNI TABRIZI, MASOUD, & KARIMI, EHSAN. (2019). Evaluation of Antioxidant and Cytotoxic Effects of Nanoemulsion of Sour Cherry Kernel Oil on A549 Lung Cancer and HUVEC Normal Cells. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 18(1 ), 71-79. SID. https://sid.ir/paper/362954/en

Vancouver: Copy

Darchini Maragheh Atieh, HOMAYOUNI TABRIZI MASOUD, KARIMI EHSAN. Evaluation of Antioxidant and Cytotoxic Effects of Nanoemulsion of Sour Cherry Kernel Oil on A549 Lung Cancer and HUVEC Normal Cells. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2019;18(1 ):71-79. Available from: https://sid.ir/paper/362954/en

IEEE: Copy

Atieh Darchini Maragheh, MASOUD HOMAYOUNI TABRIZI, and EHSAN KARIMI, “Evaluation of Antioxidant and Cytotoxic Effects of Nanoemulsion of Sour Cherry Kernel Oil on A549 Lung Cancer and HUVEC Normal Cells,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 18, no. 1 , pp. 71–79, 2019, [Online]. Available: https://sid.ir/paper/362954/en

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