Effect of garlic extract and N-acetylcysteine against fenvalerate-induced oxidative stress in the serum and testis tissue of rat

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Raji Parisa; SEYEDALIPOUR BAGHER; HAJIZADEH MOGHADDAM AKBAR

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Journal: JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES Year:2019 | Volume:21 | Issue:2 (70) Page(s): 32-41

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Title

Effect of garlic extract and N-acetylcysteine against fenvalerate-induced oxidative stress in the serum and testis tissue of rat

Author(s)

Raji Parisa | SEYEDALIPOUR BAGHER | HAJIZADEH MOGHADDAM AKBAR | Issue Writer Certificate

Keywords

Garlic extractQ1

N-acetylcysteineQ1

FenvalerateQ1

Antioxidant enzymesQ2

Oxidative stressQ2

RatQ1

Abstract

Background and Objective: rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">Fenvalerate is a component of the pyrethroid pesticide induces oxidative stress. This study was done to determine the effect of garlic extract (GE) and N-acetylcysteine (NAC) against rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">fenvalerate-induced oxidative stress in the serum and testis tissue of rat. Methods: In this experimental study, 42 Wistar rats were randomly allocated into 7 groups including: control group, sham group (normal saline), the first experimental group receiving NAC (80 mg/kg/bw), the second experimental group receiving rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">fenvalerate (10 mg/kg/bw), the third experimental group receiving rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">fenvalerate (10 mg/kg/bw) + garlic extract (40 mg/kg/bw), the fourth experimental group receiving rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">fenvalerate (10 mg/kg/bw) + NAC (80 mg/kg/bw) and the fifth experimental group receiving rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">fenvalerate (10 mg/kg/bw) + garlic extract (40 mg/kg/bw) + NAC (80 mg/kg/bw). Injection of rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">fenvalerate was performed intraperitoneally for 7 consecutive days in animals of intervention groups. Afterwards, for 10 consecutive days, NAC and garlic extract were injected. In this study, 1/40 LD50 rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">fenvalerate was used. The activity of the catalase (CAT), glutathione S-transferase (GST), malondialdehyde (MDA) and total antioxidant capacity (TAC) were determined in serum and testis tissue in all animals. Results: MDA level of serum and testis tissue in rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">fenvalerate group increased significantly compared to the control group (P<0. 05). The injection of NAC and garlic extract alone (P<0. 05) as well as garlic extract in combination with NAC reduced MDA level of serum and testis tissue compared to rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">fenvalerate group (P<0. 05). Serum TAC level was significantly reduced in rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">fenvalerate group compared to control (P<0. 05). Serum TAC level was significantly increased in rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">fenvalerate + GE group, rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">fenvalerate + NAC group and rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">fenvalerate + GE + NAC group compated to the rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">fenvalerate group (P<0. 05). GST activity of serum was significantly increased in rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">fenvalerate group compared to control (P<0. 05). GST activity of serum was significantly reduced in NAC, garlic extract and combination of NAC and garlic extact groups compared to rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">fenvalerate group (P<0. 05). Conclusion: In this animal model study, low dose (10 mg/kg/bw) rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">fenvalerate induces oxidative stress. Garlic extract and N-acetylcysteine (alone and in combination) improve injures caused by rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">fenvalerate.

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APA: Copy

Raji, Parisa, SEYEDALIPOUR, BAGHER, & HAJIZADEH MOGHADDAM, AKBAR. (2019). Effect of garlic extract and N-acetylcysteine against fenvalerate-induced oxidative stress in the serum and testis tissue of rat. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 21(2 (70) ), 32-41. SID. https://sid.ir/paper/369592/en

Vancouver: Copy

Raji Parisa, SEYEDALIPOUR BAGHER, HAJIZADEH MOGHADDAM AKBAR. Effect of garlic extract and N-acetylcysteine against fenvalerate-induced oxidative stress in the serum and testis tissue of rat. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;21(2 (70) ):32-41. Available from: https://sid.ir/paper/369592/en

IEEE: Copy

Parisa Raji, BAGHER SEYEDALIPOUR, and AKBAR HAJIZADEH MOGHADDAM, “Effect of garlic extract and N-acetylcysteine against fenvalerate-induced oxidative stress in the serum and testis tissue of rat,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. 2 (70) , pp. 32–41, 2019, [Online]. Available: https://sid.ir/paper/369592/en

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