Effect of garlic extract and N-acetylcysteine against fenvalerate-induced oxidative stress in the serum and testis tissue of rat

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Raji Parisa; SEYEDALIPOUR BAGHER; HAJIZADEH MOGHADDAM AKBAR

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Journal: JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES Year:2019 | Volume:21 | Issue:2 (70) Page(s): 32-41

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Title

Effect of garlic extract and N-acetylcysteine against fenvalerate-induced oxidative stress in the serum and testis tissue of rat

Author(s)

Raji Parisa | SEYEDALIPOUR BAGHER | HAJIZADEH MOGHADDAM AKBAR | Issue Writer Certificate

Keywords

Garlic extractQ1

N-acetylcysteineQ1

FenvalerateQ1

Antioxidant enzymesQ2

Oxidative stressQ2

RatQ1

Abstract

Background and Objective: Rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">FenvaleRate is a component of the pyrethroid pesticide induces Oxidative stress. This study was done to determine the effect of Garlic extract (GE) and N-acetylcysteine (NAC) against Rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">FenvaleRate-induced Oxidative stress in the serum and testis tissue of Rat. Methods: In this experimental study, 42 Wistar Rats were randomly allocated into 7 groups including: control group, sham group (normal saline), the first experimental group receiving NAC (80 mg/kg/bw), the second experimental group receiving Rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">FenvaleRate (10 mg/kg/bw), the third experimental group receiving Rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">FenvaleRate (10 mg/kg/bw) + Garlic extract (40 mg/kg/bw), the fourth experimental group receiving Rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">FenvaleRate (10 mg/kg/bw) + NAC (80 mg/kg/bw) and the fifth experimental group receiving Rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">FenvaleRate (10 mg/kg/bw) + Garlic extract (40 mg/kg/bw) + NAC (80 mg/kg/bw). Injection of Rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">FenvaleRate was performed intraperitoneally for 7 consecutive days in animals of intervention groups. Afterwards, for 10 consecutive days, NAC and Garlic extract were injected. In this study, 1/40 LD50 Rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">FenvaleRate was used. The activity of the catalase (CAT), glutathione S-transferase (GST), malondialdehyde (MDA) and total antioxidant capacity (TAC) were determined in serum and testis tissue in all animals. Results: MDA level of serum and testis tissue in Rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">FenvaleRate group increased significantly compared to the control group (P<0. 05). The injection of NAC and Garlic extract alone (P<0. 05) as well as Garlic extract in combination with NAC reduced MDA level of serum and testis tissue compared to Rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">FenvaleRate group (P<0. 05). Serum TAC level was significantly reduced in Rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">FenvaleRate group compared to control (P<0. 05). Serum TAC level was significantly increased in Rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">FenvaleRate + GE group, Rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">FenvaleRate + NAC group and Rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">FenvaleRate + GE + NAC group compated to the Rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">FenvaleRate group (P<0. 05). GST activity of serum was significantly increased in Rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">FenvaleRate group compared to control (P<0. 05). GST activity of serum was significantly reduced in NAC, Garlic extract and combination of NAC and garlic extact groups compared to Rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">FenvaleRate group (P<0. 05). Conclusion: In this animal model study, low dose (10 mg/kg/bw) Rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">FenvaleRate induces Oxidative stress. Garlic extract and N-acetylcysteine (alone and in combination) improve injures caused by Rate/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">FenvaleRate.

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APA: Copy

Raji, Parisa, SEYEDALIPOUR, BAGHER, & HAJIZADEH MOGHADDAM, AKBAR. (2019). Effect of garlic extract and N-acetylcysteine against fenvalerate-induced oxidative stress in the serum and testis tissue of rat. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 21(2 (70) ), 32-41. SID. https://sid.ir/paper/369592/en

Vancouver: Copy

Raji Parisa, SEYEDALIPOUR BAGHER, HAJIZADEH MOGHADDAM AKBAR. Effect of garlic extract and N-acetylcysteine against fenvalerate-induced oxidative stress in the serum and testis tissue of rat. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;21(2 (70) ):32-41. Available from: https://sid.ir/paper/369592/en

IEEE: Copy

Parisa Raji, BAGHER SEYEDALIPOUR, and AKBAR HAJIZADEH MOGHADDAM, “Effect of garlic extract and N-acetylcysteine against fenvalerate-induced oxidative stress in the serum and testis tissue of rat,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. 2 (70) , pp. 32–41, 2019, [Online]. Available: https://sid.ir/paper/369592/en

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