THE SURVEY OF THE EFFECT OF CYTOKINE IL22 ON THE ULCER ORIGINATED FROM L- MAJOR IN BALB/C MICE

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HEZARJARIBI HAJAR ZIAEE; GHAFARI FAR FATEMEH; DALIMI ASL ABDOLHOSSEIN; SHARIFI ZOHREH

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Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2012 | Volume:21 | Issue:SUPPLEMENT 1 Page(s): 285-294

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Title

THE SURVEY OF THE EFFECT OF CYTOKINE IL22 ON THE ULCER ORIGINATED FROM L- MAJOR IN BALB/C MICE

Author(s)

HEZARJARIBI HAJAR ZIAEE | GHAFARI FAR FATEMEH | DALIMI ASL ABDOLHOSSEIN | SHARIFI ZOHREH | Issue Writer Certificate

Keywords

LEISHMANIA AND RATQ2

BALB/CQ2

Abstract

Background and purpose: IL22 is the family member of IL10 that is created by Th17, Th22, NK cells and recently the role of Il22 in protection and inherent defense mechanisms, in the control of bacterial and viral infection, homeostasis and repair tissue has been demonstrated. So in this research the effect of Il22 treatment on lesion originated from L-major in BALB/C mice has been survived.Materials and methods: 24 female BALB/C mice for 8 weeks old at least 2x106 Promastigotes of L-Major Iraninan standard strain MR HO/IR/75/ER in stationary phase through 100 micro liter subcutaneous challenged and in three of eight groups of mice has been injected by 5ng/ml and 10ng/ml (IM) with recombinant IL22. Immunity cellular and homoral with assessment cytokines IL 4Results: IFN-Ã, cultures spleen lymphocyte cells and survey of IgG2a, IgG Total with Elisa method and MTT method and clinical study measuring the wound healing and lifespan of mice and death registration was done.Conclusion: The study conclusion indicated that the growth of ulcer especially has been reduced in IL-22 groups and the greatest effect in IL-22(5ng) group. IL-22(5ng) has caused the increased production of, IFN-Ã and the reduced IL4.The LSD test has shown that, IFN-Ã, IGg Total with P<0.05 significant in IL22-5ng groups rather than other groups and IL4 with P<0.05 non significant in IL22-5ng but significant with other groups. IGg2a in IL22-5ng with P<0.05 is not significant with IL22-10ng groups. but significant with other groups. MTT IL22-5ng is significant with other groups.We can infer that increasing IFN-Ã and reducing IL4 by IL22-5ng has caused the protective immunity in L-major, so if it is used with the anti leishmania drug combined may have effective results in treatment.

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APA: Copy

HEZARJARIBI, HAJAR ZIAEE, GHAFARI FAR, FATEMEH, DALIMI ASL, ABDOLHOSSEIN, & SHARIFI, ZOHREH. (2012). THE SURVEY OF THE EFFECT OF CYTOKINE IL22 ON THE ULCER ORIGINATED FROM L- MAJOR IN BALB/C MICE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 21(SUPPLEMENT 1), 285-294. SID. https://sid.ir/paper/44757/en

Vancouver: Copy

HEZARJARIBI HAJAR ZIAEE, GHAFARI FAR FATEMEH, DALIMI ASL ABDOLHOSSEIN, SHARIFI ZOHREH. THE SURVEY OF THE EFFECT OF CYTOKINE IL22 ON THE ULCER ORIGINATED FROM L- MAJOR IN BALB/C MICE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;21(SUPPLEMENT 1):285-294. Available from: https://sid.ir/paper/44757/en

IEEE: Copy

HAJAR ZIAEE HEZARJARIBI, FATEMEH GHAFARI FAR, ABDOLHOSSEIN DALIMI ASL, and ZOHREH SHARIFI, “THE SURVEY OF THE EFFECT OF CYTOKINE IL22 ON THE ULCER ORIGINATED FROM L- MAJOR IN BALB/C MICE,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. SUPPLEMENT 1, pp. 285–294, 2012, [Online]. Available: https://sid.ir/paper/44757/en

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