AN OVERVIEW ON ANTICANCER DRUGS WITH ANTILEISHMANIAL ACTIVITY

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KEIGHOBADI MASOUD; AKHTARI JAVAD; FAKHAR MAHDI; EMAMI SAEED; MIRZAEI HASSAN

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:28 | Issue:161 Page(s): 154-165

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Title

AN OVERVIEW ON ANTICANCER DRUGS WITH ANTILEISHMANIAL ACTIVITY

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Keywords

LEISHMANIASISQ2

DRUG TARGETSQ1

ANTI-CANCER DRUGSQ1

Abstract

LEISHMANIASIS is a major public health problem, but so far there are no effective commerciallyavailable vaccines for this disease. Its control strategy is only reliant on therapy, but currently the drugsavailable for the treatment of LEISHMANIASIS are also limited and a great concern is the rapid rate ofresistance to common drugs. The first step in discovery and development of new drugs is to identify anappropriate drug target. Accordingly, it is important to recognize the metabolic pathways in which theleishmania parasites live and selecting a target in the parasite biological pathway, absent in the host ordifferent from the host homolog. Discovery of new drugs requires high costs and takes a lot of time (up to15 years). Therefore, choosing the approved drugs in the market for various diseases, includingLEISHMANIASIS is very cost-effective considering the mechanism of drug action and other aspects. Miltefosin is an effective anti-cancer agent that is also used for different types of LEISHMANIASIS. In recentyears, researchers have focused on the anti-leishmanial effects of pharmaceutical compounds or anticancerdrugs to find more effective compounds with lower side effects. The present article mainly reviews theanticancer drugs that have been tested for their anti-leishmanial effects in both in vitro and in vivoconditions.

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APA: Copy

KEIGHOBADI, MASOUD, AKHTARI, JAVAD, FAKHAR, MAHDI, EMAMI, SAEED, & MIRZAEI, HASSAN. (2018). AN OVERVIEW ON ANTICANCER DRUGS WITH ANTILEISHMANIAL ACTIVITY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 28(161 ), 154-165. SID. https://sid.ir/paper/45475/en

Vancouver: Copy

KEIGHOBADI MASOUD, AKHTARI JAVAD, FAKHAR MAHDI, EMAMI SAEED, MIRZAEI HASSAN. AN OVERVIEW ON ANTICANCER DRUGS WITH ANTILEISHMANIAL ACTIVITY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;28(161 ):154-165. Available from: https://sid.ir/paper/45475/en

IEEE: Copy

MASOUD KEIGHOBADI, JAVAD AKHTARI, MAHDI FAKHAR, SAEED EMAMI, and HASSAN MIRZAEI, “AN OVERVIEW ON ANTICANCER DRUGS WITH ANTILEISHMANIAL ACTIVITY,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 161 , pp. 154–165, 2018, [Online]. Available: https://sid.ir/paper/45475/en

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