EFFECTS OF PHARMACOLOGIC PRECONDITIONING BY NATURAL HONEY ON ARRHYTHMIAS AND INFARCT SIZE IN ISOLATED HEART

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NAJAFI MOSLEM; MAHDIZADEH AGHDAM E.; RAFIEI FARZANEH; ETERAF OSKOUEI T.

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Journal: PHARMACEUTICAL SCIENCES Year:2008 | Volume:- | Issue:4 Page(s): 1-11

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Title

EFFECTS OF PHARMACOLOGIC PRECONDITIONING BY NATURAL HONEY ON ARRHYTHMIAS AND INFARCT SIZE IN ISOLATED HEART

Author(s)

NAJAFI MOSLEM | MAHDIZADEH AGHDAM E. | RAFIEI FARZANEH | ETERAF OSKOUEI T. | Issue Writer Certificate

Keywords

NATURAL HONEYQ2

ARRHYTHMIASQ2

INFARCT SIZEQ2

PHARMACOLOGIC PRECONDITIONINGQ2

ISCHEMIA/REPERFUSIONQ2

ISOLATED HEARTQ2

Abstract

Objectives: In this study, prophylactic effects of NATURAL HONEY as a PHARMACOLOGIC PRECONDITIONING agent on ISCHEMIA/REPERFUSION (I/R) induced cardiac ARRHYTHMIAS and INFARCT SIZE were investigated in isolated rat heart. Methods: Isolated rat hearts were mounted on a Langendorff apparatus then subjected to 30min regional ischemia followed by 120min reperfusion. In control group, the hearts were perfused by a modified Krebs-Henseleit solution throughout the experiment, however, in the test groups they were perfused by enriched Krebs solution with NATURAL HONEY (0.25, 0.5 and 1%) 10min before to 10min after ischemia. The ARRHYTHMIAS were analyzed based on the Lambeth conventions. The INFARCT SIZE was determined by Triphenyltetrazolium chloride and planimetry methods. Results: At the ischemia, the total number of ventricular ectopic beats (VEBs) in the control group was 667±116 while perfusion of NATURAL HONEY (0.25, 0.5 and 1%) reduced it to 128±35 (p<0.01), 161±35 (p<0.01) and 303±94 (p<0.05), respectively. The number of ischemic ventricular tachycardia (VT) and the time spent in VT were significantly lowered by the same concentrations. Honey (0.25 and 0.5%) decreased the incidence of VT from 100% (control) to 13% (p<0.001) and 25% (p<0.01), respectively. During reperfusion phase, the number of VEBs and VT were significantly reduced by all used concentrations. In addition, honey (0.25%) significantly decreased the incidence and time spent for reversible ventricular fibrillation. Moreover, perfusion of honey (0.25, 0.5 and 1%) reduced INFARCT SIZE from 46.3±2.9% (control value) to 3.3±1.3, 9.2±1.9 and 11.7±2.2%, respectively (p<0.001 for all). Conclusion: The results of this study showed antiarrhythmic and anti-infarct properties of NATURAL HONEY as a preconditioning agent against I/R injuries in isolated rat heart. Probably, antioxidant activity of honey, scavenging of free radicals and presence of energy sources such as glucose may involve in these cardioprotective effects.

Cites

EFFECTS OF CHRONIC ORAL ADMINISTRATION OF NATURAL HONEY ON ISCHEMIA/REPERFUSION-INDUCED ARRHYTHMIAS IN ISOLATED RAT HEART

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APA: Copy

NAJAFI, MOSLEM, MAHDIZADEH AGHDAM, E., RAFIEI, FARZANEH, & ETERAF OSKOUEI, T.. (2008). EFFECTS OF PHARMACOLOGIC PRECONDITIONING BY NATURAL HONEY ON ARRHYTHMIAS AND INFARCT SIZE IN ISOLATED HEART. PHARMACEUTICAL SCIENCES, -(4), 1-11. SID. https://sid.ir/paper/48507/en

Vancouver: Copy

NAJAFI MOSLEM, MAHDIZADEH AGHDAM E., RAFIEI FARZANEH, ETERAF OSKOUEI T.. EFFECTS OF PHARMACOLOGIC PRECONDITIONING BY NATURAL HONEY ON ARRHYTHMIAS AND INFARCT SIZE IN ISOLATED HEART. PHARMACEUTICAL SCIENCES[Internet]. 2008;-(4):1-11. Available from: https://sid.ir/paper/48507/en

IEEE: Copy

MOSLEM NAJAFI, E. MAHDIZADEH AGHDAM, FARZANEH RAFIEI, and T. ETERAF OSKOUEI, “EFFECTS OF PHARMACOLOGIC PRECONDITIONING BY NATURAL HONEY ON ARRHYTHMIAS AND INFARCT SIZE IN ISOLATED HEART,” PHARMACEUTICAL SCIENCES, vol. -, no. 4, pp. 1–11, 2008, [Online]. Available: https://sid.ir/paper/48507/en

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