STUDY OF EFFECT OF NARDOSTACHYS JATAMANSI DC RHIZOMES EXTRACT ON TOLERANCE INDUCED BY MORPHINE IN MICE AND THE EFFECTIVENESS OF ITS COADMINISTRATION WITH KETAMINE

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HABIBIASL B.; HAGHEERMADADI M.; ASNAASHARI S.; DELAZAR A.

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Journal: PHARMACEUTICAL SCIENCES Year:2006 | Volume:- | Issue:3 Page(s): 1-6

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Title

STUDY OF EFFECT OF NARDOSTACHYS JATAMANSI DC RHIZOMES EXTRACT ON TOLERANCE INDUCED BY MORPHINE IN MICE AND THE EFFECTIVENESS OF ITS COADMINISTRATION WITH KETAMINE

Author(s)

HABIBIASL B. | HAGHEERMADADI M. | ASNAASHARI S. | DELAZAR A. | Issue Writer Certificate

Keywords

MORPHINEQ2

KETAMINQ2

NARDOSTACHY JATAMANSIQ2

TOLERANCEQ2

GC-MSQ2

Abstract

Objectives: Nardostachys Jatamansi DC has been used in traditional medicines of various countries because of seadative, anticonvulsion and analgesic properties. Methods: In this study, first, the rhizome of N. Jatamansi was extracted by hydromethanolic (70%) solvent and then, the presence of valporoates, in total extract, was revealed by GC-MS analysis of its n- Hexane fraction. For studying the effectiveness of N. Jatamansi total extract (NJTE) and its co-administration with KETAMINe (Ket.) in MORPHINE induced TOLERANCE, different groups of mice received MORPHINE (30mg/kg, ip) , MORPHINE (30mg/kg, ip) + Ket. (25, 50, 75 mg/kg, ip), MORPHINE (30 mg/kg, ip) + NJTE (10,20,30 mg/kg, ip) or MORPHINE (30mg/kg, ip) + Ket. (25 mg/kg, ip) + NJTE (10mg/kg, ip) for four days. Pretreatment was done 30 min before daily MORPHINE administration. TOLERANCE was assessed by administration of MORPHINE (9mg/kg, ip) and using hot-plate test on fifth day. Results: The GC-MS analysis of the n-hexan fraction of total extract led to the identification and quantification of fifteen compounds, the main components were 9- Aristolen-1-alpha-ol (31.1%), Valerenal (31%) and Valerenic acid (26.5%). Pharmacological results showed that Ket. inhibited the development of MORPHINE induced TOLERANCE in the dose dependent manner although the maximum inhibition was observed at the dose of 20 mg/kg of NJTE. Co-administration of both drugs revealed synergistic effect. Conclusion: NJTE, Ket. and co-administration of both drugs significantly inhibited the development of MORPHINE induced TOLERANCE.

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APA: Copy

HABIBIASL, B., HAGHEERMADADI, M., ASNAASHARI, S., & DELAZAR, A.. (2006). STUDY OF EFFECT OF NARDOSTACHYS JATAMANSI DC RHIZOMES EXTRACT ON TOLERANCE INDUCED BY MORPHINE IN MICE AND THE EFFECTIVENESS OF ITS COADMINISTRATION WITH KETAMINE. PHARMACEUTICAL SCIENCES, -(3), 1-6. SID. https://sid.ir/paper/48521/en

Vancouver: Copy

HABIBIASL B., HAGHEERMADADI M., ASNAASHARI S., DELAZAR A.. STUDY OF EFFECT OF NARDOSTACHYS JATAMANSI DC RHIZOMES EXTRACT ON TOLERANCE INDUCED BY MORPHINE IN MICE AND THE EFFECTIVENESS OF ITS COADMINISTRATION WITH KETAMINE. PHARMACEUTICAL SCIENCES[Internet]. 2006;-(3):1-6. Available from: https://sid.ir/paper/48521/en

IEEE: Copy

B. HABIBIASL, M. HAGHEERMADADI, S. ASNAASHARI, and A. DELAZAR, “STUDY OF EFFECT OF NARDOSTACHYS JATAMANSI DC RHIZOMES EXTRACT ON TOLERANCE INDUCED BY MORPHINE IN MICE AND THE EFFECTIVENESS OF ITS COADMINISTRATION WITH KETAMINE,” PHARMACEUTICAL SCIENCES, vol. -, no. 3, pp. 1–6, 2006, [Online]. Available: https://sid.ir/paper/48521/en

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