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Information Journal Paper

Title

EFFECT OF GARLIC EXTRACT ON CUTANEOUS LEISHMANIASIS AND THE ROLE OF NITRIC OXIDE

Pages

  1-7

Abstract

 Nitric oxide (NO) is important for healing of LEISHMANIASIS in human and animal. In this study, 42 mice were infected with Leishmania major by injecting 1x105promastigotes into the base of tail to induce a lesion. Then the effects of GARLIC extract alone or in combination with vitamin A on healing of LEISHMANIASIS and on NO release were compared with the effects of glocantime. Mice were treated with the drugs two times daily for 45 days. The diameter of lesion was measured on days 1, 10, 20, 30 and 45 following drug administration. Also the rate of NO release in the culture of peritoneal macrophages was measured. The results showed that the diameters of lesions were reduced by aqueous extract of GARLIC over 30 days of treatment. However, the maximum reduction was achieved when mice were subjected to 10 days of vitamin A ointment, then treated for 45 days with GARLIC extract. There was a significant correlation between healing level and the amount of NO release.

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References

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APA: Copy

AHMADI, KAZEM, MAHMOUDZADEH POURNAKI, ABAS, CHERAGHALI, A., & ESFAHANI, A.A.. (2002). EFFECT OF GARLIC EXTRACT ON CUTANEOUS LEISHMANIASIS AND THE ROLE OF NITRIC OXIDE. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, 4(2), 1-7. SID. https://sid.ir/paper/58500/en

Vancouver: Copy

AHMADI KAZEM, MAHMOUDZADEH POURNAKI ABAS, CHERAGHALI A., ESFAHANI A.A.. EFFECT OF GARLIC EXTRACT ON CUTANEOUS LEISHMANIASIS AND THE ROLE OF NITRIC OXIDE. JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2002;4(2):1-7. Available from: https://sid.ir/paper/58500/en

IEEE: Copy

KAZEM AHMADI, ABAS MAHMOUDZADEH POURNAKI, A. CHERAGHALI, and A.A. ESFAHANI, “EFFECT OF GARLIC EXTRACT ON CUTANEOUS LEISHMANIASIS AND THE ROLE OF NITRIC OXIDE,” JOURNAL OF SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES, vol. 4, no. 2, pp. 1–7, 2002, [Online]. Available: https://sid.ir/paper/58500/en

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