STUDIES ON FLAVONOIDS AS ANTIOXIDANTS ON THE AFFINITY OF LDL TO ITS RECEPTOR:A
MODEL FOR PRENTION OF ATHEROSCLEROSIS

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SAFARI M.R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Studies in Medical Sciences Year:2002 | Volume:13 | Issue:1 Page(s): 51-60

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Title

STUDIES ON FLAVONOIDS AS ANTIOXIDANTS ON THE AFFINITY OF LDL TO ITS RECEPTOR:A MODEL FOR PRENTION OF ATHEROSCLEROSIS

Author(s)

SAFARI M.R. | Issue Writer Certificate

Keywords

LDLQ4

LDL RECEPTORQ4

ATHEROSCLEROSISQ3

FLAVONOIDQ4

Abstract

Introduction: There are many evidences that the low density lipoprotein (LDL) oxidation displays the key role in atherogenesis. When LDL is oxidized, the affinity LDL to its receptor is decreased. The accumulation of the oxidized-LDL in macrophage leads to the appearance of foam cells and formation of artherosclerosis. For several years, scientists tried to find antioxidant compounds that inhibit the oxidation of LDL but have no destructive effects. Recently, the FLAVONOIDs have reserved attention as antioxidant agents. The aim of this study is possible use of these compounds in preventing or treating ATHEROSCLEROSIS. Materials & Methods: In this study, the effects of various concentrations of four FLAVONOIDs including: "Ginestin, Morin, Naringin and Quercetin " on the affinity of natural-LDL and oxidized-LDL (with Cu+2) to its receptor bovine adrenal tissue cells have been investigated in the presence of labeled-LDL with fluoresein isothiocyanate (FITC). First, after purification of LDL-solvent of normal serum and incubation, oxidation reaction performed and LDL-solvent was labeled with FITC, and then all solvents were added to the medium that contains adrenal tissue cells (with LDL-receptor). Finally, fluorescence intensity of supernatant of each sample was determined in spcetrofluorometer. Results: Results showed that among FLAVONOIDs uscd, 'Quercetin,' was the best compound that was increased the affinity of LDL to its receptor (for natural-LDL 30% and for oxidized-LDL 75%). The effects of them were dose-dependent and the best concentration was 200 micromolar. Discussion: These finding showed that the FLAVONOIDs probably can change the affinity of LDL to its receptor and thus may prevent formation of ATHEROSCLEROSIS.

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APA: Copy

SAFARI, M.R.. (2002). STUDIES ON FLAVONOIDS AS ANTIOXIDANTS ON THE AFFINITY OF LDL TO ITS RECEPTOR:A MODEL FOR PRENTION OF ATHEROSCLEROSIS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), 13(1), 51-60. SID. https://sid.ir/paper/63933/en

Vancouver: Copy

SAFARI M.R.. STUDIES ON FLAVONOIDS AS ANTIOXIDANTS ON THE AFFINITY OF LDL TO ITS RECEPTOR:A MODEL FOR PRENTION OF ATHEROSCLEROSIS. STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES)[Internet]. 2002;13(1):51-60. Available from: https://sid.ir/paper/63933/en

IEEE: Copy

M.R. SAFARI, “STUDIES ON FLAVONOIDS AS ANTIOXIDANTS ON THE AFFINITY OF LDL TO ITS RECEPTOR:A MODEL FOR PRENTION OF ATHEROSCLEROSIS,” STUDIES IN MEDICAL SCIENCE (THE JOURNAL OF URMIA UNIVERSITY OF MEDICAL SCINCES), vol. 13, no. 1, pp. 51–60, 2002, [Online]. Available: https://sid.ir/paper/63933/en

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