PROTECTIVE EFFECTS OF ERYNGIUM CAUCASICUM TRAUTV HYDROALCHOLIC EXTRACT ON TRICYCLAZOLE INDUCED HEPATOTOXICITY IN MICE

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FATTAHI ESMAEIL; HEMAYATKHAH JAHROMI VAHID

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2016 | Volume:19 | Issue:8 (113) Page(s): 67-78

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Title

PROTECTIVE EFFECTS OF ERYNGIUM CAUCASICUM TRAUTV HYDROALCHOLIC EXTRACT ON TRICYCLAZOLE INDUCED HEPATOTOXICITY IN MICE

Author(s)

FATTAHI ESMAEIL | HEMAYATKHAH JAHROMI VAHID | Issue Writer Certificate

Keywords

ERYNGIUM CAUCASICUM TRAUTVQ1

HEPATO PROTECTIVEQ1

PHENOLIC COMPOUNDSQ1

TRICYCLAZOLEQ1

Abstract

Background: ERYNGIUM CAUCASICUM TRAUTV has antioxidant properties due to the presence of flavonoids andphenolic compounds. So, the present study was done to investigate the protective effects of Eryngium caucasicumTrautv extract on TRICYCLAZOLE induced hepatotoxicity in mice.Materials and Methods: In this experimental study, 42 mice were divided into 6 groups including control, sham, TRICYCLAZOLE (TCZ) and three experimental groups. The mice in the TRICYCLAZOLE group, received 50 mg/kg TCZvia intraperitoneal injection and experimental groups 2, 3 and 4 received respectively 100, 200 and 400 mg/kg of extractvia gavage for 4 weeks and 2 days per week. The sham group received only sterile water. At the end, serumlevels of ALT, AST and ALP, serum concentration of albumin and total bilirubin were measured. Also, total phenoliccompounds and flavonoids in the extract were measured. Data were analyzed by using ANOVA.Results: TRICYCLAZOLE increased serum levels of aminotransferase, phosphatase alkaline and total bilirubinand decreased serum concentration of albumin. But, treatment with extract decreased liver enzymes and bilirubin andincreased levels of albumin (p<0.05). Amount of total PHENOLIC COMPOUNDS and the flavonoids were measured 91.16mg/gr galicacid in extract and 84.48 mg/gr quercetin in extract, respectively.Conclusion: The results demonstrated that ERYNGIUM CAUCASICUM TRAUTV extract due to the presence of highphenolic compounds has protective effects on TRICYCLAZOLE induced hepatotoxicity.

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APA: Copy

FATTAHI, ESMAEIL, & HEMAYATKHAH JAHROMI, VAHID. (2016). PROTECTIVE EFFECTS OF ERYNGIUM CAUCASICUM TRAUTV HYDROALCHOLIC EXTRACT ON TRICYCLAZOLE INDUCED HEPATOTOXICITY IN MICE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 19(8 (113)), 67-78. SID. https://sid.ir/paper/69165/en

Vancouver: Copy

FATTAHI ESMAEIL, HEMAYATKHAH JAHROMI VAHID. PROTECTIVE EFFECTS OF ERYNGIUM CAUCASICUM TRAUTV HYDROALCHOLIC EXTRACT ON TRICYCLAZOLE INDUCED HEPATOTOXICITY IN MICE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2016;19(8 (113)):67-78. Available from: https://sid.ir/paper/69165/en

IEEE: Copy

ESMAEIL FATTAHI, and VAHID HEMAYATKHAH JAHROMI, “PROTECTIVE EFFECTS OF ERYNGIUM CAUCASICUM TRAUTV HYDROALCHOLIC EXTRACT ON TRICYCLAZOLE INDUCED HEPATOTOXICITY IN MICE,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 19, no. 8 (113), pp. 67–78, 2016, [Online]. Available: https://sid.ir/paper/69165/en

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