INVESTIGATION OF ERG11 GENE MUTATIONS IN FLUCONAZOLE RESISTANT CANDIDA ALBICANS ISOLATED FROM A NUMBER OF RASHT HOSPITALS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

EFTEKHARI AZADEH DOKHT; ANVARI MASUMEH; RANJI NAJMEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Pathobiology Research Year:2015 | Volume:18 | Issue:3 Page(s): 97-107

Download Full-Text

Persian Verion

View:

1,068

Download:

Cites:

Information Journal Paper

Title

INVESTIGATION OF ERG11 GENE MUTATIONS IN FLUCONAZOLE RESISTANT CANDIDA ALBICANS ISOLATED FROM A NUMBER OF RASHT HOSPITALS

Author(s)

EFTEKHARI AZADEH DOKHT | ANVARI MASUMEH | RANJI NAJMEH | Issue Writer Certificate

Keywords

CANDIDA ALBICANSQ3

FLUCONAZOLEQ2

ERG11Q2

Abstract

Objective: Azole antifungal drugs have been a treatment option for CANDIDA ALBICANS infections. However, azole resistance can occur through different mechanisms such as alterations in ERG11 (lanosterol 14α-demethylase). This study assesses ERG11 gene mutations in CANDIDA ALBICANS strains isolated from patients with Candidia Volvo vaginitis in a number of Rasht hospitals between 2012-2014 by direct PCR and sequencing.Methods: We identified the yeast strains by standard identification methods, such as germ tubes. Drug sensitivity was determined as MIC 90 values by the macro dilution broth method based on the CLSI protocol. We screened the resistant strains prior to DNA extraction and ERG11 gene mutations were confirmed by PCR sequencing.Results: From 40 strains, 4 showed high levels of resistance to FLUCONAZOLE. Of these, two species had a MIC 90 of 512mg/ml and the other two species had a MIC 90 of 1024 mg/ml. Three strains had D116E and V456G polymorphisms.Conclusion: The most FLUCONAZOLE resistant CANDIDA ALBICANS strains worldwide were reported. Our results suggested a correlation between the polymorphism and FLUCONAZOLE resistance in the CANDIDA ALBICANS strains.

Cites

CORRELATION BETWEEN ERG11 GENE MUTATIONS AND FLUCONAZOLE RESISTANCE IN CANDIDA ALBICANS STRAINS ISOLATED FROM RASHT IN YEARS 2015-2016

References

No record.

Cite

APA: Copy

EFTEKHARI, AZADEH DOKHT, ANVARI, MASUMEH, & RANJI, NAJMEH. (2015). INVESTIGATION OF ERG11 GENE MUTATIONS IN FLUCONAZOLE RESISTANT CANDIDA ALBICANS ISOLATED FROM A NUMBER OF RASHT HOSPITALS. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), 18(3), 97-107. SID. https://sid.ir/paper/81166/en

Vancouver: Copy

EFTEKHARI AZADEH DOKHT, ANVARI MASUMEH, RANJI NAJMEH. INVESTIGATION OF ERG11 GENE MUTATIONS IN FLUCONAZOLE RESISTANT CANDIDA ALBICANS ISOLATED FROM A NUMBER OF RASHT HOSPITALS. PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES)[Internet]. 2015;18(3):97-107. Available from: https://sid.ir/paper/81166/en

IEEE: Copy

AZADEH DOKHT EFTEKHARI, MASUMEH ANVARI, and NAJMEH RANJI, “INVESTIGATION OF ERG11 GENE MUTATIONS IN FLUCONAZOLE RESISTANT CANDIDA ALBICANS ISOLATED FROM A NUMBER OF RASHT HOSPITALS,” PATHOBIOLOGY RESEARCH (MODARES JOURNAL OF MEDICAL SCIENCES), vol. 18, no. 3, pp. 97–107, 2015, [Online]. Available: https://sid.ir/paper/81166/en

Related Journal Papers