EFFECTS OF ω3-FATTY ACID SUPPLEMENT ON SERUM LIPIDS AND LIPOPROTEINS IN HEMODIALYSIS PATIENTS

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KOUSHKI A.; TALEBAN F.A.Z.; TABIBI H.; NOURAFSHAR R.; HEDAYATI MAHDI

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Journal: Journal of Sabzevar University of Medical Sciences Year:2009 | Volume:16 | Issue:1 (51) Page(s): 25-34

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Title

EFFECTS OF ω3-FATTY ACID SUPPLEMENT ON SERUM LIPIDS AND LIPOPROTEINS IN HEMODIALYSIS PATIENTS

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Abstract

Background and Purpose: Research on non-hemodialysis patients has shown that w3-fatty acid supplement can reduce the concentration of serum Lp(a). Therefore, the present study was designed to investigate the effects of w3-fatty acid supplement on serum lipids and lipoproteins in hemodialysis patients.Methods and Materials: This double-blind randomized clinical trial was conducted on 40 hemodialysis patients in 2008 in Vase’i Hospital in Sabzevar, Iran; they were randomly assigned to either w3-fatty acid supplement or placebo group. Patients in the w3-fatty acid supplement group received 2080 mg w3-fatty acid daily as 4 capsules, while the placebo group received 4 corresponding placebo capsules containing MCT oil. At baseline and the end of week 10 of the study, 5 ml blood samples were collected from each patient after a 12 to 14-hour fasting before dialysis; their serum triglyceride, total cholesterol, LDL-C, HDL-C and Lp(a) were measured. The obtained data were analyzed in SPSS using Chi-square, t-test, 32±paired t-test and ANOVA.Results: Serum triglyceride concentration were 113 19 in the supplement and placebo groups respectively in the beginning and 109 17 at the end of week 10. The reduction±25 and 115±the amounts decreased to 101 was significant in the supplement group (p<0.01) and the difference between the supplement and placebo group was significant (P<0.0.006). However, no significant differences were observed between the two groups as for the changes of serum total cholesterol, LDL-C, HDL-C and Lp(a) concentrations (P>0.05).Conclusion: Results of the present study indicate that w3-fatty acid supplement can reduce serum triglyceride concentration in hemodialysis patients but it does not affect other serum lipids and lipoproteins in hemodialysis patients.

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APA: Copy

KOUSHKI, A., TALEBAN, F.A.Z., TABIBI, H., NOURAFSHAR, R., & HEDAYATI, MAHDI. (2009). EFFECTS OF ω3-FATTY ACID SUPPLEMENT ON SERUM LIPIDS AND LIPOPROTEINS IN HEMODIALYSIS PATIENTS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 16(1 (51)), 25-34. SID. https://sid.ir/paper/82568/en

Vancouver: Copy

KOUSHKI A., TALEBAN F.A.Z., TABIBI H., NOURAFSHAR R., HEDAYATI MAHDI. EFFECTS OF ω3-FATTY ACID SUPPLEMENT ON SERUM LIPIDS AND LIPOPROTEINS IN HEMODIALYSIS PATIENTS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2009;16(1 (51)):25-34. Available from: https://sid.ir/paper/82568/en

IEEE: Copy

A. KOUSHKI, F.A.Z. TALEBAN, H. TABIBI, R. NOURAFSHAR, and MAHDI HEDAYATI, “EFFECTS OF ω3-FATTY ACID SUPPLEMENT ON SERUM LIPIDS AND LIPOPROTEINS IN HEMODIALYSIS PATIENTS,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 16, no. 1 (51), pp. 25–34, 2009, [Online]. Available: https://sid.ir/paper/82568/en

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