EFFECTS OF WIN55,212-2 IN THE DORSAL HIPPOCAMPUS ON SCOPOLAMINE STATE-DEPENDENT MEMORY

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PIRI MORTEZA; NASEHI MOHAMMAD; SHAHIN MARYAM OL SADAT; ZARRINDAST MOHAMMAD REZA

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Journal: ADVANCES IN COGNITIVE SCIENCE Year:2010 | Volume:12 | Issue:1 (45) Page(s): 43-51

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Title

EFFECTS OF WIN55,212-2 IN THE DORSAL HIPPOCAMPUS ON SCOPOLAMINE STATE-DEPENDENT MEMORY

Author(s)

PIRI MORTEZA | NASEHI MOHAMMAD | SHAHIN MARYAM OL SADAT | ZARRINDAST MOHAMMAD REZA | Issue Writer Certificate

Keywords

SCOPOLAMINEQ3

WIN55Q3

21Q3

2Q3

STATE-DEPENDENT MEMORYQ3

PASSIVE AVOIDANCE TASKQ3

MOUSEQ3

Abstract

Objective: To assess the effects of the cannabinoid receptor agonist, WIN55, 212-2 on SCOPOLAMINE induced STATE-DEPENDENT MEMORY. Method: The step-down passive avoidance paradigm was used in the present study, which is an accepted model to examine long-term memory in mice.Results: Post-training intra-CA1 administration of SCOPOLAMINE (2 and 4 µg/mouse) decreased the memory retrieval. Pre-test SCOPOLAMINE administration restored the retrieval to the control level in the test day. This phenomenon is known as SCOPOLAMINE STATE-DEPENDENT MEMORY. Administration of WIN55, 212-2 (1 µg/mouse, intra-CA1) 5 min before test by itself decreased the memory retrieval. On the other hand, the animals in which memory retrieval was impaired due to SCOPOLAMINE (2 µg/mouse) post-training administration, pre-test administration of WIN55, 212-2 (1 µg/mouse, intra-CA1) 24 hr after training on the day of the test restored memory. Moreover, pre-test co-administration of non-effective dose of SCOPOLAMINE with ineffective dose of WIN55, 212-2 increased the restoration of memory by SCOPOLAMINE.Conclusion: These results suggest that cannabinoid receptors of the dorsal hippocampal CA1 regions may play an important role in SCOPOLAMINE-induced amnesia and SCOPOLAMINE STATE-DEPENDENT MEMORY.

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APA: Copy

PIRI, MORTEZA, NASEHI, MOHAMMAD, SHAHIN, MARYAM OL SADAT, & ZARRINDAST, MOHAMMAD REZA. (2010). EFFECTS OF WIN55,212-2 IN THE DORSAL HIPPOCAMPUS ON SCOPOLAMINE STATE-DEPENDENT MEMORY. ADVANCES IN COGNITIVE SCIENCE, 12(1 (45)), 43-51. SID. https://sid.ir/paper/82718/en

Vancouver: Copy

PIRI MORTEZA, NASEHI MOHAMMAD, SHAHIN MARYAM OL SADAT, ZARRINDAST MOHAMMAD REZA. EFFECTS OF WIN55,212-2 IN THE DORSAL HIPPOCAMPUS ON SCOPOLAMINE STATE-DEPENDENT MEMORY. ADVANCES IN COGNITIVE SCIENCE[Internet]. 2010;12(1 (45)):43-51. Available from: https://sid.ir/paper/82718/en

IEEE: Copy

MORTEZA PIRI, MOHAMMAD NASEHI, MARYAM OL SADAT SHAHIN, and MOHAMMAD REZA ZARRINDAST, “EFFECTS OF WIN55,212-2 IN THE DORSAL HIPPOCAMPUS ON SCOPOLAMINE STATE-DEPENDENT MEMORY,” ADVANCES IN COGNITIVE SCIENCE, vol. 12, no. 1 (45), pp. 43–51, 2010, [Online]. Available: https://sid.ir/paper/82718/en

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