INFLUENCE OF INTRACEREBRAL ADMINISTRATION OF L-NAME IN DORSAL HIPPOCAMPUS (CA1) ON WIN55, 212-2 INDUCED STATE-DEPENDENT MEMORY IN THE STEP-DOWN PASSIVE AVOIDANCE TEST

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NASEHI M.; PIRI M.; ZARINDAST M.R.

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Journal Paper

Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2009 | Volume:19 | Issue:71 Page(s): 1-9

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Title

INFLUENCE OF INTRACEREBRAL ADMINISTRATION OF L-NAME IN DORSAL HIPPOCAMPUS (CA1) ON WIN55, 212-2 INDUCED STATE-DEPENDENT MEMORY IN THE STEP-DOWN PASSIVE AVOIDANCE TEST

Author(s)

NASEHI M. | PIRI M. | ZARINDAST M.R. | Issue Writer Certificate

Keywords

WIN55Q3

212-2Q3

L-NAMEQ2

STATE-DEPENDENT MEMORYQ2

STEP-DOWN PASSIVE AVOIDANCE TASKQ2

MICEQ2

Abstract

Background and purpose: This study presents the effects of nitricoxide synthase inhibitor (L-NAME) on WIN55, 212-2 induced STATE-DEPENDENT MEMORY of passive avoidance task, which were examined in MICE. Materials and methods: MICE were anesthetized with intra-peritoneal injection of ketamine hydrochloride, plus xylazine and then placed in a stereotaxic apparatus. Also, two stainless-steel annuals were placed 1 min above CA1. One-trial step-down paradigm was used for the assessment of memory retention in adult male NMRI MICE. Results: Post-training intra-CA1 administration of WIN55, 212-2 (0.5 and 1 mg/mouse), dose-dependent decreased the memory retrieval. The memory impairment induced by post-training administration of WIN55, 212-2 (1mg/mouse), was restored by pre-test administration with the same dose of drug (1mg/mouse, intra-CA1). Single intra-CA1 administration of L-NAME (0.3, 1 and 3 mg/mouse), 5 minute pre-test could not alter memory retrieval. Also, in animals in which retrieval was impaired due to post-training administration of WIN55, 212-2 (1mg/mouse), pre-test intra-CA1 administration of L-NAME (0.3, 1 and 3 mg/mouse) 24 hours after training, could not restore memory retrieval. Furthermore, in animals which received both post-training (1mg/mouse) and pre-test injection of WIN55, 212-2 (1mg/mouse), the injection of L-NAME (3 mg/mouse, intra-CA1), 2 minute before pre-test administration decreased retrieval. Conclusion: These findings may demonstrate the involvement of NO in STATE-DEPENDENT MEMORY induced by intra-CA1 administration of WIN55, 212-2.

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APA: Copy

NASEHI, M., PIRI, M., & ZARINDAST, M.R.. (2009). INFLUENCE OF INTRACEREBRAL ADMINISTRATION OF L-NAME IN DORSAL HIPPOCAMPUS (CA1) ON WIN55, 212-2 INDUCED STATE-DEPENDENT MEMORY IN THE STEP-DOWN PASSIVE AVOIDANCE TEST. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 19(71), 1-9. SID. https://sid.ir/paper/46168/en

Vancouver: Copy

NASEHI M., PIRI M., ZARINDAST M.R.. INFLUENCE OF INTRACEREBRAL ADMINISTRATION OF L-NAME IN DORSAL HIPPOCAMPUS (CA1) ON WIN55, 212-2 INDUCED STATE-DEPENDENT MEMORY IN THE STEP-DOWN PASSIVE AVOIDANCE TEST. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2009;19(71):1-9. Available from: https://sid.ir/paper/46168/en

IEEE: Copy

M. NASEHI, M. PIRI, and M.R. ZARINDAST, “INFLUENCE OF INTRACEREBRAL ADMINISTRATION OF L-NAME IN DORSAL HIPPOCAMPUS (CA1) ON WIN55, 212-2 INDUCED STATE-DEPENDENT MEMORY IN THE STEP-DOWN PASSIVE AVOIDANCE TEST,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 19, no. 71, pp. 1–9, 2009, [Online]. Available: https://sid.ir/paper/46168/en

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