INFLUENCE OF INTRACEREBRAL ADMINISTRATION OF L-ARGININE IN DORSAL HIPPOCAMPUS (CA1) ON WIN55, 212-2 INDUCED STATE-DEPENDENT MEMORY

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PIRI MORTEZA; NASEHI M.; ZARINDAST M.R.

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Journal: Journal of Advances in Medical and Biomedical Research Year:2010 | Volume:18 | Issue:70 Page(s): 10-21

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Title

INFLUENCE OF INTRACEREBRAL ADMINISTRATION OF L-ARGININE IN DORSAL HIPPOCAMPUS (CA1) ON WIN55, 212-2 INDUCED STATE-DEPENDENT MEMORY

Author(s)

PIRI MORTEZA | NASEHI M. | ZARINDAST M.R. | Issue Writer Certificate

Keywords

WIN55Q3

212-2Q3

STATE-DEPENDENT MEMORYQ2

STEP-DOWN PASSIVE AVOIDANCE TASKQ2

L-ARGININEQ2

NOQ2

MICEQ2

Abstract

Background and Objective: Cannabinoids are a class of psychoactive compounds that produce a wide array of effects in a large number of species. In the present study, the effects of bilateral intra-CA1 injections of L-ARGININE on WIN55, 212-2 induced STATE-DEPENDENT MEMORY of passive avoidance task was examined in MICE. Materials and Methods: One-trial step-down paradigm was used for the assessment of memory retention in adult male NMRI MICE. Results: Post-training intra-CA1 administration of cannabinoid receptor agonist, WIN55, 212-2 (0.5 and 1 mg/mouse), decreased the memory retrieval. The memory impairment induced by post-training administration of WIN55, 212-2 (1mg/mouse) was restored by pre-test administration of the same dose of the drug, showing the STATE-DEPENDENT MEMORY of WIN55, 212-2. Single intra-CA1 administration of L-ARGININE (0.3, 1 and 3 mg/mouse) 5 min pre-test could NOt alter the memory retrieval. On the other hand, in the animals in which retrieval was impaired due to post-training administration of WIN55, 212-2 (1mg/mouse), pre-test intra-CA1 administration of L-ARGININE (1 and 3 mg/mouse), 24 hr after training restored memory retrieval. Furthermore, in the animals under influence of post-training administration of WIN55, 212-2 (1mg/mouse), pre-test co-administration of NOn-effective doses of WIN55, 212-2 and L-ARGININE, increased the restoration of memory by the pre-test WIN55, 212-2. Conclusion: The findings of the present study suggest that NO system of dorsal hippocampus may play an important role in WIN55, 212-2-induced amnesia and WIN55, 212-2 STATE-DEPENDENT MEMORY.

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APA: Copy

PIRI, MORTEZA, NASEHI, M., & ZARINDAST, M.R.. (2010). INFLUENCE OF INTRACEREBRAL ADMINISTRATION OF L-ARGININE IN DORSAL HIPPOCAMPUS (CA1) ON WIN55, 212-2 INDUCED STATE-DEPENDENT MEMORY. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, 18(70), 10-21. SID. https://sid.ir/paper/61517/en

Vancouver: Copy

PIRI MORTEZA, NASEHI M., ZARINDAST M.R.. INFLUENCE OF INTRACEREBRAL ADMINISTRATION OF L-ARGININE IN DORSAL HIPPOCAMPUS (CA1) ON WIN55, 212-2 INDUCED STATE-DEPENDENT MEMORY. JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH[Internet]. 2010;18(70):10-21. Available from: https://sid.ir/paper/61517/en

IEEE: Copy

MORTEZA PIRI, M. NASEHI, and M.R. ZARINDAST, “INFLUENCE OF INTRACEREBRAL ADMINISTRATION OF L-ARGININE IN DORSAL HIPPOCAMPUS (CA1) ON WIN55, 212-2 INDUCED STATE-DEPENDENT MEMORY,” JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH, vol. 18, no. 70, pp. 10–21, 2010, [Online]. Available: https://sid.ir/paper/61517/en

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