EVALUATION OF CYTOTOXICITY EFFECT OF SHARK CARTILAGE EXTRACT ON BREAST ADENOCARCINOMA CELL LINE(MCF7)

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SHAHROKHI S.; GHAZANFARI T.; MOHAGHEGHI S.M.A.; MOHAMMAD HASAN ZOHEYR; BABAEI GH.R.

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Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2005 | Volume:13 | Issue:2 Page(s): 12-18

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Title

EVALUATION OF CYTOTOXICITY EFFECT OF SHARK CARTILAGE EXTRACT ON BREAST ADENOCARCINOMA CELL LINE(MCF7)

Author(s)

Keywords

BREAST ADENOCARCIOMAQ2

SHARK CARTILAGEQ4

CYTOTOXICITYQ4

Abstract

Introduction: Several studies have supported have supported the shark cartigle contains antiagiogenic andante tumor comounds, it's antiangiogenic properties has been confirmed, which is an important mechanism in inhibiting tumor cell growth, but it's cytotoxic effect on tumor cell could be another mechanism and there is little dcientific evidence approving this. So, we evaluated this effect on human adenocarcinoma cell line (MCF7.)Materials & methods: To assess the CYTOTOXICITY effect of SHARK CARTILAGE extract on MCF7 and L929 cell lines, they were cultured and propagated then incubated with different doses of shark cartialige (25µg, 50µg, 75 µg, 100 µg) for 24, 48 and 72 hrs. After the incubation period MTT test was done.Results: The results of MTT showed that this extract has dose dependent CYTOTOXICITY on tumor cells. For example, the highest CYTOTOXICITY was seen in incubating cell with 100µg of extract for 72 hrs, while there was no CYTOTOXICITY in normal cells which shows the differential CYTOTOXICITY effect of SHARK CARTILAGE extract on tumor cells.Discussion: Considering the finds, SHARK CARTILAGE extract can inhibit the tumor cell growth through a CYTOTOXICITY as well as it's anti-angiogenicity.

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APA: Copy

SHAHROKHI, S., GHAZANFARI, T., MOHAGHEGHI, S.M.A., MOHAMMAD HASAN, ZOHEYR, & BABAEI, GH.R.. (2005). EVALUATION OF CYTOTOXICITY EFFECT OF SHARK CARTILAGE EXTRACT ON BREAST ADENOCARCINOMA CELL LINE(MCF7). JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 13(2), 12-18. SID. https://sid.ir/paper/89792/en

Vancouver: Copy

SHAHROKHI S., GHAZANFARI T., MOHAGHEGHI S.M.A., MOHAMMAD HASAN ZOHEYR, BABAEI GH.R.. EVALUATION OF CYTOTOXICITY EFFECT OF SHARK CARTILAGE EXTRACT ON BREAST ADENOCARCINOMA CELL LINE(MCF7). JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2005;13(2):12-18. Available from: https://sid.ir/paper/89792/en

IEEE: Copy

S. SHAHROKHI, T. GHAZANFARI, S.M.A. MOHAGHEGHI, ZOHEYR MOHAMMAD HASAN, and GH.R. BABAEI, “EVALUATION OF CYTOTOXICITY EFFECT OF SHARK CARTILAGE EXTRACT ON BREAST ADENOCARCINOMA CELL LINE(MCF7),” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 13, no. 2, pp. 12–18, 2005, [Online]. Available: https://sid.ir/paper/89792/en

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