THE EXPANSION OF MICRO-RNA 21 (MIR-21) IN THE SERUM OF PATIENTS WITH GASTRIC CANCER

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PARTO P.; MASOUDIAN N.

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Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2016 | Volume:23 | Issue:6 Page(s): 10-19

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Title

THE EXPANSION OF MICRO-RNA 21 (MIR-21) IN THE SERUM OF PATIENTS WITH GASTRIC CANCER

Author(s)

PARTO P. | MASOUDIAN N. | Issue Writer Certificate

Keywords

GASTRIC ADENOCARCINOMAQ2

MICRORNAQ1

MIR-21Q2

Abstract

Introduction: MICRORNAs (miRNAs) are new group of regulatory RNAs with approximately 22 nucleotides in length. The miRNAs have important role in human cancers and apparently function as either oncogenes or tumor suppressors. In this study, serum level of MIR-21 was determined in patients with GASTRIC ADENOCARCINOMA and its correlation with tumor staging was assessed in the patients, for the first time, in Iran.Materials & methods: The study was conducted on 40 patients with GASTRIC ADENOCARCINOMA and 40 control subjects who had referred to cancer institute due to gastrointestinal irritation but were diagnosed as healthy on noncancerous. Serum levels of miR 21 were measured using a quantitative Real-time polymerase chain reaction (qRT-PCR) assay. The correlation of miR 21 serum level with tumor staging was assessed in the patients.Results: Serum level of miR 21 was approximately 3.5 fold higher in patients with GASTRIC ADENOCARCINOMA than control subjects (P<0.0001). Increased level of MIR-21 in serum was associated with clinical stages of tumors in the patients (τ=0.56, P<0.01).Discussion & Conclusions: Given the importance of miR 21 in the progression of GASTRIC ADENOCARCINOMA and its correlation with clinicopathological factors, the serum level of MIR-21 can be served as a new noninvasive diagnostic biomarker for GASTRIC ADENOCARCINOMA.

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APA: Copy

PARTO, P., & MASOUDIAN, N.. (2016). THE EXPANSION OF MICRO-RNA 21 (MIR-21) IN THE SERUM OF PATIENTS WITH GASTRIC CANCER. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 23(6), 10-19. SID. https://sid.ir/paper/89992/en

Vancouver: Copy

PARTO P., MASOUDIAN N.. THE EXPANSION OF MICRO-RNA 21 (MIR-21) IN THE SERUM OF PATIENTS WITH GASTRIC CANCER. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;23(6):10-19. Available from: https://sid.ir/paper/89992/en

IEEE: Copy

P. PARTO, and N. MASOUDIAN, “THE EXPANSION OF MICRO-RNA 21 (MIR-21) IN THE SERUM OF PATIENTS WITH GASTRIC CANCER,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 23, no. 6, pp. 10–19, 2016, [Online]. Available: https://sid.ir/paper/89992/en

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