The aim of the present study was to investigate the relationship of religious attitudes, psychological well-being and depression with academic performance in university students. The present research was of correlation type. The statistical population in this research was students in Islamic Azad University, Ahvaz Branch. The sample of research included 200 students (100 girls, 100 boys) who were selected based on stratified random sampling. The measurement instruments consisted of, Religions Belief Inventory (Arian, 1998), Satisfaction with Life Scale (SWLS) (Dinner et al., 1985), Beck Depression Inventory (BDI) (Beck, 1978), and student scholastic average as academic performance index. To analyze the data, Pearson correlation coefficient and multivariable regression analysis were employed. The results revealed that the relationship of religious attitudes, psychological well-being and depression with academic performance is significant (P<0.01). Also, the result of regression analysis showed that religious attitude, psychological well-being and depression are respectively convenient predictors of academic performance.