It seem that there is an association among physical activity (PA), aerobic fitness and future heart disease (CHD) mortality. Energy expenditure can be an appropriate index to determine PA amount affected by intensity and duration of PA. The purpose of this study was to determine the relationship between energy expenditure, aerobic fitness and coronary heart disease (CHD) risk factors. Fifty male students (Age 22.52±2.80 yr. Height 175.3±7.12cm, Weight 7/.90±10.24kg, EE 2676±461, Vo2 max 56.57±5.03 ml/kg/min) in Gilan University took part in this study. Subjects completed an informed consent form, health history and Bouchard questionnaire. This questionnaire was translated and after piloting, it was used in Iran. Measurements included percent body fat (PBF), body mass index (BMI), waist hip ratio (WHR), body weight (BW) and coronary heart disease risk factors (TC, TG, LDL-c, HDL-c, SBP & DBP). Pierson correlation coefficient was performed for analyzing data and the maximal level of significance for this study was p≤0.05. The results of this study indicated that EE correlated with TC, LDL-c, TCIHDL-c, DBP, PBF, BMI and BW significantly related to TC, LDL-c, PBF, BMI and BW There was a significant relationship between PBF with TC, LDL-c, BW with SBP and DBP (P≤0.05). The results indicated that students' health more effected than EE and aerobic fitness although body fat is related to coronary heart disease risk factors. Therefore, it could decline the CHD risk with a decrease in EE and aerobic fitness.