Introduction: Infantile colic is a painful condition in the first months of infancy. This study wascarried out with the aim of testing the hypothesis that massage treatment has a clinically relevanteffect on this condition. Materials and Methods: This randomized clinical trial was conductedamong 100 infants of<12 weeks of age with infantile colic. They were randomly assigned to eitherinfant massage (n=50) or rocking groups (n=50). In the massage group, trained individualstaught the parents of the infants the massage technique and gave them a brochure. Rocking groupparents was recommended to rock their infants three times a day for 1 week. Parents recordedthe pattern of crying (numbers, length, and severity of crying). After 1 week of intervention, data were analysed using t‑test, Chi square test, and repeated measurement analysis of variance(P<0.05).Results: Significant differences were not observed in infant and mother demographicinformation. Before intervention, the mean of total number, length, and severity of crying were6.12 (1.76) time/day, 4.97 (1.37) hour/day, and 6.60 (1.54) in the massage group and 6.96 (2.9)time/day, 3 (1.31) hour/day, and 5.98 (2.22) in the rocking group, respectively. After 1 week ofintervention, the mean difference of total number, length, and severity of crying were 4.08 (1.83)time/day, 2.81 (1.77) hour/day, and 2.9 (2.37) in the massage group and 0.56 (2.28) time/day, 0.27 (1.09) hour/day, and 0.02 (1.64) in the rocking group, respectively. Conclusions: This trial ofmassage treatment for infantile colic showed statistically significant or clinically relevant effect incomparison with the rocking group.