The purpose of this study was to design a strategic entrepreneurial model in the tourism industry with an exploratory mixed approach in the companies providing tourism services in the center, east and south of the country (Tehran, Mashhad and Shiraz). This research is applied-developmental in terms of nature, exploratory and mixed-heuristic in terms of data collection. In the qualitative part of the study, the research team consisted of 30 experts, including academic experts and managers of tourism service companies, selected by non-random method. The statistical population in the quantitative section consisted of 263 companies providing tourism services in the center, east and south of the country with 3, 5 and 163 sample size was estimated by stratified random sampling. In the qualitative section, the data collected was analyzed using Nvivo version 8 software and formulated in the conceptual data model of the Foundation. In the model test, the research hypotheses were first formulated and then analyzed by path analysis using SPSS software version 25 and Smart-PLS version 3. 2. The results of the quantitative phase showed that causal conditions affecting strategic entrepreneurship include social aspect, destination environment, and entrepreneurship growth and destination development. Intervening conditions include communication, predictability and new investment, and contextual conditions include resource gathering, human capital and productivity. The strategies outlined include cultural-social growth, the impact of incentives, and systemic engagement to improve performance, integration, and maximize the use of experiences as strategic entrepreneurial outcomes.