Background and Objectives: With the expansion of e-learning, one important aspect of change in education is in the field of teaching and learning, including the relation between the teacher and the learner. In the analysis and evaluation of the nature of this relation and its role in human cognition, one of the post structuralist emerging paradigms is Deleuze's rhizomatic epistemology. independent studies have been done in the area of Deleuze's ideas and electronic learning based on connectivism theory. However, what distinguishes this study from other studies is that: can the new territory that Deleuze names rhizomatic and by whose means challenges the traditional relationships between the teacher and the learner in the tree system and deterritorializes, support the new atmosphere of electronic learning? Do these two accompany each other? The aim of this research thus is examining the nature of the relationship between teacher and learner in comprehensive e-learning process with an emphasis on the ideas of Deleuze. Methods: The methodology of this study is philosophical analysis and deduction, which were used to answer the research question (What is the nature of the relation between the teacher and the learner in the process of e-learning? ). The method of data collection is desk-documentation study. Based on concept analysis, valid understanding of the concept and a clear explanation of its relationship with other concepts was achieved. Moreover, based on deductive approach, the implications of the nature of the relation between the teacher and the learner according to Deleuze's ideas in the process of teaching-learning in e-learning was assessed. Then, these were analyzed philosophically. In other words, Deleuze's rhizomatic epistemological concepts and the related elements on the one hand and the concepts of electronic learning based on connectivism theory on the other hand were analyzed, interpreted and clarified. In the end, the proportion of relation in e-learning to Deleuze's rhizomatic relation was evaluated. Findings: First, basic factors in rhizomatic epistemology of Deleuze were investigated. Based on the findings of this study, the essentialistic of the relationship between the teacher and the learner, according to Deleuze’ s opinions, is rhizomatic. This means that it has certain features such as interconnection and heterogeneity, pluralism, immigration, mapping, and non-indicative dissociation of rhizome, suggesting nonlinear, horizontal and non-hierarchical, fluid and fragile, decentralizing, spontaneous and molecular, dense and multiplexed, flexible and permeable relationships. Second, the nature of relationship in virtual learning process was illuminated. According to the theory of communication, communication in e-learning is a systemic and network communication in which non-linear relationships are established between system components and the network. According to this theory, e-learning is the process of network components communicating with each other. Finally, the nature of communication in e-learning was evaluated in relation to the nature of communication in Deleuze rhizomatic epistemology. Therefore, it is interpreted that the orientation of communication in e-learning is in line with Deleuze's rhizomatic relationship. Conclusion: Based on connectivism theory, electronic education is the very process of network elements connecting with each other. Thus, the direction of e-learning is aligned with Deleuze's rhizomatic relation. Thus, Deleuze's rhizomatic relationships with regard to the capabilities it holds, promises the ideal relationship between the teacher and the learner in the e-learning era and can serve as a model to address some of the challenges of the traditional educational system.