Background: The psychological dysregulation inventory is a powerful and multidimensional tool in identifying and diagnosing behavioral and mental health problems in adolescents. Therefore, study of its validity and reliability in adolescents is necessary. Aims: The purpose of the present research was to examine the validity and reliability of the Persian version of psychological dysregulation inventory among adolescents. Method: The research design was descriptive and it was a type of factor analysis, and the statistical population of this study was all students of Tabriz secondary school, a sample of 440 people was selected by cluster sampling. The data were collected by the psychological dysregulation inventory (Mezzich and colleague, 2001). Results: The reliability coefficients obtained for behavioral dysregulation, cognitive dysregulation, emotional dysregulation components and total scale, were respectively, 0/90, 0/88, 0/85 and 0/95, which indicate a good reliability. Results of Confirmatory Factor Analysis indicated that significant relationship between observed variables and the Latent structures confirmed, and the threefactor in this sample was appropriate fitness. Conclusions: The psychological dysregulation inventory among the adolescents has good reliability and validity, and use of this tool in future research is reliable.