THE SURVEY ON -592 POLYMORPHISM OF INTERLUKIN-10 IN HEPATITIS B VIRUS INFECTED PATIENTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

BAGHERI MANSOORi MOHAMMAD HASSAN; SHARIFI ZOHREH; SANATI MOHAMMAD HOSSEIN; SHAHZADEH FAZELI ABOLHASSAN; FARHANGNIA MANSOUREH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Isfahan Medical School Year:2014 | Volume:31 | Issue:271 Page(s): 2434-2441

Download Full-Text

Persian Verion

View:

962

Download:

Cites:

Information Journal Paper

Title

THE SURVEY ON -592 POLYMORPHISM OF INTERLUKIN-10 IN HEPATITIS B VIRUS INFECTED PATIENTS

Author(s)

Keywords

SINGLE NUCLEOTIDE POLYMORPHISMS (SNPS)Q2

INTERLEUKINQ1

10 (ILQ2

10)Q2

HEPATITIS B VIRUS (HBV)Q2

ALLELEQ2

SPECIFIC POLYMERASE CHAIN REACTIONQ2

Abstract

Background: Infection with hepatitis B virus (HBV) may result in a number of different clinical outcomes. There are strong evidences in HBV infection that host genetic factors play a major role in determining the outcome of infection. Polymorphisms in the promoter region of INTERLEUKIN 10 (IL-10) affect its production and confer susceptibility to inflammatory diseases. The aim of present study was to investigate the association between HBV infection and -592 polymorphism in the promoter region of the IL-10 gene in Iranian population.Methods: 100 HBV infected patients and 100 healthy individuals were randomly selected. Genomic DNA was extracted from blood buffy coat using the salting-out method. The IL-10-592(A/C) genotypes were determined using allele-specific polymerase chain reaction (PCR) method. The PCR products were electrophoresed on 1.5% agarose gel. The data were analyzed using chi-square test.Findings: The frequency of IL-10-592 C/C genotype was 16% in patients infected with HBV and 12% in healthy individuals and was not significantly different (P=0.5). Also, the frequency of C variant allele was 55.5% in HBV infected patients and 53% in healthy individuals that was not statistically different (P=0.6).Conclusion: Based on our findings, there was not any relationship between IL-10-592 (A/C) polymorphism and susceptibility to HBV infection in our study population.

Cites

References

No record.

Cite

APA: Copy

BAGHERI MANSOORi, MOHAMMAD HASSAN, SHARIFI, ZOHREH, SANATI, MOHAMMAD HOSSEIN, SHAHZADEH FAZELI, ABOLHASSAN, & FARHANGNIA, MANSOUREH. (2014). THE SURVEY ON -592 POLYMORPHISM OF INTERLUKIN-10 IN HEPATITIS B VIRUS INFECTED PATIENTS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 31(271), 2434-2441. SID. https://sid.ir/paper/50754/en

Vancouver: Copy

BAGHERI MANSOORi MOHAMMAD HASSAN, SHARIFI ZOHREH, SANATI MOHAMMAD HOSSEIN, SHAHZADEH FAZELI ABOLHASSAN, FARHANGNIA MANSOUREH. THE SURVEY ON -592 POLYMORPHISM OF INTERLUKIN-10 IN HEPATITIS B VIRUS INFECTED PATIENTS. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2014;31(271):2434-2441. Available from: https://sid.ir/paper/50754/en

IEEE: Copy

MOHAMMAD HASSAN BAGHERI MANSOORi, ZOHREH SHARIFI, MOHAMMAD HOSSEIN SANATI, ABOLHASSAN SHAHZADEH FAZELI, and MANSOUREH FARHANGNIA, “THE SURVEY ON -592 POLYMORPHISM OF INTERLUKIN-10 IN HEPATITIS B VIRUS INFECTED PATIENTS,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 31, no. 271, pp. 2434–2441, 2014, [Online]. Available: https://sid.ir/paper/50754/en

Related Journal Papers