THE ROLE OF ADENOSINE AL RECEPTORS ON EPILEPTIC ACTIVITY OF THE HIPPOCAMPUS AND AMYGDALA IN HIPPOCAMPAL KINDLED RATS

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MIRNAJAFIZADEH S.J.; FATH ELAHI Y.; POURGHOLAMI M.H.

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Journal: Researcher Bulletin of Medical Sciences Year:2005 | Volume:10 | Issue:3 (45) Page(s): 153-160

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Title

THE ROLE OF ADENOSINE AL RECEPTORS ON EPILEPTIC ACTIVITY OF THE HIPPOCAMPUS AND AMYGDALA IN HIPPOCAMPAL KINDLED RATS

Author(s)

MIRNAJAFIZADEH S.J. | FATH ELAHI Y. | POURGHOLAMI M.H. | Issue Writer Certificate

Keywords

SEIZUREQ3

ADENOSINEQ3

HIPPOCAMPUSQ3

KINDLINGQ3

Abstract

Background: The HIPPOCAMPUS is among the most sensitive brain regions in producing epileptic activity and there are many researches about the role of different agents on the SEIZUREs induced from hippocampal neuronal activity. In this research, the role of intraperitoneal injection of N6- cyclohexyladenosine (CHA), a selective ADENOSINE A1 receptors agonist, and 1, 3-dimethyl-8- cyclopenthylxanthine (CPT), a selective A1 receptors antagonist, on hippocampal kindled SEIZUREs was investigated.Materials and methods: Intraperitoneal CHA (0.25, 0.5 and 1mg/kg) reduced hippocampal and amygdala after discharge duration (ADD) significantly. The stage 4 SEIZURE latency was also increased significantly by CHA at the dose of 1mg/kg. Intraperitoneal CPT (0.25, 0.5 and 1mg/kg) increased stage 5 SEIZURE duration, hippocampal secondary ADD and amygdala ADD significantly. Pretreatment of CPT (0.5 mg/kg) 5 min before CHA, reduced the effects of CHA on SEIZURE parameters.Results: All hippocampal kindled animals showd stage 5 SEIZUREs before and after salin injection. CHA and CPT in administered doses, had no significant effects on behavior or motor activity of rats. Althogh, CHA did not change hippocampal ADD and S5D, but significantly increased S4D.This effect was dose dependent.Conclusion: The results showed that in hippocampal kindled SEIZUREs, ADENOSINE receptors have anticonvulsant effects and injection of A1 receptor agonists enhanced this effect. In addition it may be suggested this anticonvulsant effect may be exerted in part through activity of ADENOSINE A1 receptors.

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APA: Copy

MIRNAJAFIZADEH, S.J., FATH ELAHI, Y., & POURGHOLAMI, M.H.. (2005). THE ROLE OF ADENOSINE AL RECEPTORS ON EPILEPTIC ACTIVITY OF THE HIPPOCAMPUS AND AMYGDALA IN HIPPOCAMPAL KINDLED RATS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 10(3 (45)), 153-160. SID. https://sid.ir/paper/18429/en

Vancouver: Copy

MIRNAJAFIZADEH S.J., FATH ELAHI Y., POURGHOLAMI M.H.. THE ROLE OF ADENOSINE AL RECEPTORS ON EPILEPTIC ACTIVITY OF THE HIPPOCAMPUS AND AMYGDALA IN HIPPOCAMPAL KINDLED RATS. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2005;10(3 (45)):153-160. Available from: https://sid.ir/paper/18429/en

IEEE: Copy

S.J. MIRNAJAFIZADEH, Y. FATH ELAHI, and M.H. POURGHOLAMI, “THE ROLE OF ADENOSINE AL RECEPTORS ON EPILEPTIC ACTIVITY OF THE HIPPOCAMPUS AND AMYGDALA IN HIPPOCAMPAL KINDLED RATS,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 10, no. 3 (45), pp. 153–160, 2005, [Online]. Available: https://sid.ir/paper/18429/en

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