EFFECT OF CIMETIDINE ON INTENSITY AND DURATION OF POST OPERATION PAIN IN COMPARISON WITH MORPHINE

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FOROUZESHFARD M.; MILADI GORJI H.

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Journal: Koomesh Year:2006 | Volume:7 | Issue:1-2 Page(s): 1-6

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Information Journal Paper

Title

EFFECT OF CIMETIDINE ON INTENSITY AND DURATION OF POST OPERATION PAIN IN COMPARISON WITH MORPHINE

Author(s)

FOROUZESHFARD M. | MILADI GORJI H. | Issue Writer Certificate

Keywords

CIMETIDINEQ4

MORPHINEQ2

ANTINOCICEPTIONQ3

ANALGESIAQ3

POST-OPERATION PAINQ3

SURGERYQ3

Abstract

Introduction: Pain is the most common complaint of patients and its treatment is the most ancient problem of human being. Opioids have many side effects that have limited MORPHINE administration. Recent studies have shown that CIMETIDINE (CIM) induces ANALGESIA in animals. Thus, this study was designed to evaluate the effect of CIM on modulation of post-operative pain in comparison with MORPHINE (MOR). Materials and Methods: This study was a double blind clinical trial. 90 patients (male & female) after earning satisfaction were divided into three groups: 1-CIM (5 mg/kg), 2-MOR (0.1 mg/kg), and 3-CIM+MOR. Drugs were injected (IV) in peak of pain during post-operation period. Numeric rating pain scale (RPS) method was used for pain scaling. Pain was measured in 30 min and 60 min after the drug injection.Results: Confounding variables including age, sex, and type of anesthesia and SURGERY had no significant effects on pain scores. Pain intensity was not significant at 30 and 60 min after the drug or vehicle injections among three groups, but it was significantly lower when compared with pain score before injection of drugs (P=0.0001). Also, there were no significant differences in duration of ANALGESIA among three groups Conclusion: The above findings indicated that the analgesic effect (time and quality) of CIM is compatible, with that of MORPHINE.

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References

THE ROLE OF ATP-SENSITIVE POTASSIUM CHANNELS AND OPIOID RECEPTORS ON CIMETIDINE ANTINOCICEPTION IN MOUSE

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APA: Copy

FOROUZESHFARD, M., & MILADI GORJI, H.. (2006). EFFECT OF CIMETIDINE ON INTENSITY AND DURATION OF POST OPERATION PAIN IN COMPARISON WITH MORPHINE. KOOMESH, 7(1-2), 1-6. SID. https://sid.ir/paper/37390/en

Vancouver: Copy

FOROUZESHFARD M., MILADI GORJI H.. EFFECT OF CIMETIDINE ON INTENSITY AND DURATION OF POST OPERATION PAIN IN COMPARISON WITH MORPHINE. KOOMESH[Internet]. 2006;7(1-2):1-6. Available from: https://sid.ir/paper/37390/en

IEEE: Copy

M. FOROUZESHFARD, and H. MILADI GORJI, “EFFECT OF CIMETIDINE ON INTENSITY AND DURATION OF POST OPERATION PAIN IN COMPARISON WITH MORPHINE,” KOOMESH, vol. 7, no. 1-2, pp. 1–6, 2006, [Online]. Available: https://sid.ir/paper/37390/en

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