The effect of six weeks of voluntary wheel running exercise on hepatic superoxide dismutase levels and apoptosis-inducing factor after doxorubicin administration in aging model rats

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Sadat Hoseini S.K.; DABIDI ROSHAN V.

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Journal: Feyz Medical Sciences Journal Year:2018 | Volume:22 | Issue:3 Page(s): 267-273

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Title

The effect of six weeks of voluntary wheel running exercise on hepatic superoxide dismutase levels and apoptosis-inducing factor after doxorubicin administration in aging model rats

Author(s)

Sadat Hoseini S.K. | DABIDI ROSHAN V. | Issue Writer Certificate

Keywords

Voluntary exerciseQ1

DoxorubicinQ1

Hepatic toxicityQ2

Oxidative stressQ2

ApoptosisQ1

Abstract

Background: In the last decade, cancer incidence increases progressively with age and older patients cannot participate in treatment programs due to the special physical condition and side effects of anti-tumor drugs. Therefore, the aim of this study was to examine the effect of six-week voluntary wheel running exercise on Doxorubicin (DOX)-induced hepatotoxicity in aging model rats. Materials and Methods: Thirty-two Wistar male rats were randomly assigned to exercise and control groups with 4 subgroups. All subjects received a daily injection of D-galactose for nine weeks (100 mg/kg/day, intraperitoneally). The training protocol included six weeks of voluntary wheel running exercise. Doxorubicin was administrated intraperitoneally (1mg/kg/day) for 15 days. Superoxide dismutase (SOD) and Apoptosis-inducing factor (AIF) levels were measured after liver tissue homogenization by enzyme-linked immunosorbent assay (ELISA) method. Results: Administration of cumulative dose of DOX caused no significant decrease in SOD and AIF levels (P=0. 797, and P=0. 869, respectively). Six weeks of voluntary wheel running exercise led to insignificant decrease in SOD and insignificant increase in AIF in comparison to the control group (P=0. 377, and P=0. 948, respectively). Conclusion: According to the results of the present study, the six-week voluntary wheel running exercise has no significant effect on DOX-induced hepatotoxicity in aging model rats.

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APA: Copy

Sadat Hoseini, S.K., & DABIDI ROSHAN, V.. (2018). The effect of six weeks of voluntary wheel running exercise on hepatic superoxide dismutase levels and apoptosis-inducing factor after doxorubicin administration in aging model rats. FEYZ, 22(3 ), 267-273. SID. https://sid.ir/paper/40614/en

Vancouver: Copy

Sadat Hoseini S.K., DABIDI ROSHAN V.. The effect of six weeks of voluntary wheel running exercise on hepatic superoxide dismutase levels and apoptosis-inducing factor after doxorubicin administration in aging model rats. FEYZ[Internet]. 2018;22(3 ):267-273. Available from: https://sid.ir/paper/40614/en

IEEE: Copy

S.K. Sadat Hoseini, and V. DABIDI ROSHAN, “The effect of six weeks of voluntary wheel running exercise on hepatic superoxide dismutase levels and apoptosis-inducing factor after doxorubicin administration in aging model rats,” FEYZ, vol. 22, no. 3 , pp. 267–273, 2018, [Online]. Available: https://sid.ir/paper/40614/en

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