INFLUENCE OF WIN55, 212-2 ON MORPHINE STATE-DEPENDENT MEMORY IN THE STEP-DOWN PASSIVE AVOIDANCE TEST

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NAVAEIAN M.; PIRI M.; PAKPOUR B.

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Journal: SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES Year:2011 | Volume:16 | Issue:3 (SERIAL NUMBER 61) Page(s): 84-94

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Title

INFLUENCE OF WIN55, 212-2 ON MORPHINE STATE-DEPENDENT MEMORY IN THE STEP-DOWN PASSIVE AVOIDANCE TEST

Author(s)

NAVAEIAN M. | PIRI M. | PAKPOUR B. | Issue Writer Certificate

Keywords

CANNABINOIDSQ2

MORPHINEQ2

INHIBITORY AVOIDANCE TASKQ2

Abstract

Background and Aim: Both endogenous CANNABINOIDS and opiate substances have high levels of expression in the brain and may have important neuromodulatory functions. The present study evaluated the possible role of cannabinoid system of the dorsal hippocampus in MORPHINE induced amnesia and MORPHINE state-dependent memory in adult male mice.Material and Methods: In this experimental study 255 adult male NMRI mice were anaesthetized and put into a stereotaxic device and cannula were implanted bilaterally in the CA1 regions of their dorsal hippocampus. Seven days after recovery from surgery, the behavioral testing was started by use of INHIBITORY AVOIDANCE TASK. In this study MORPHINE and WIN55, 212-2 was used as opioid receptor agonist and cannabinoid receptor agonist respectively.Results: Intra peritoneal (i.p.) administration of MORPHINE immediately after training, decreased memory formation in a dose-dependent way (P<0.01). Amnesia induced by post-training MORPHINE injection was reversed by pre-test administration of the same dose of MORPHINE that is due to a state-dependent effect (P<0.001). Pre-test intra-CA1 administration of WIN55 212-2 after training, reversed amnesia induced by MORPHINE and restored normal memory state (P<0.001).Conclusion: The results of this study suggested that cannabinoid receptors of the dorsal hippocampal CA1 regions might play an important role in MORPHINE-induced amnesia and MORPHINE state-dependent memory.

Cites

THE EFFECT OF D2 RECEPTOR AGONIST INJECTION IN THE NUCLEUS ACCUMBENS ON RESTORATION OF MORPHINE INDUCED AMNESIA BY NICOTINE IN MALE RATS

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APA: Copy

NAVAEIAN, M., PIRI, M., & PAKPOUR, B.. (2011). INFLUENCE OF WIN55, 212-2 ON MORPHINE STATE-DEPENDENT MEMORY IN THE STEP-DOWN PASSIVE AVOIDANCE TEST. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, 16(3 (SERIAL NUMBER 61)), 84-94. SID. https://sid.ir/paper/76922/en

Vancouver: Copy

NAVAEIAN M., PIRI M., PAKPOUR B.. INFLUENCE OF WIN55, 212-2 ON MORPHINE STATE-DEPENDENT MEMORY IN THE STEP-DOWN PASSIVE AVOIDANCE TEST. SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2011;16(3 (SERIAL NUMBER 61)):84-94. Available from: https://sid.ir/paper/76922/en

IEEE: Copy

M. NAVAEIAN, M. PIRI, and B. PAKPOUR, “INFLUENCE OF WIN55, 212-2 ON MORPHINE STATE-DEPENDENT MEMORY IN THE STEP-DOWN PASSIVE AVOIDANCE TEST,” SCIENTIFIC JOURNAL OF KURDISTAN UNIVERSITY OF MEDICAL SCIENCES, vol. 16, no. 3 (SERIAL NUMBER 61), pp. 84–94, 2011, [Online]. Available: https://sid.ir/paper/76922/en

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