The aim of this study was examination of the role of organizational commitment, social support, general health and job satisfaction in predicting burnout among the staff of Social security organization at Kohgiluyeh and Boyer Ahmad. The method of this study was correlational. The statistic population was all staff of Social security organization (302 persons) at Kohgiluyeh and Boyer Ahmad in 2012. 184 persons of them were selected as sample using simple random sampling method.. The Research tool are organizational commitment questionnaire (Allen and Mayer, 1984), job satisfaction questionnaire (Brifield and Roth, 1951), general health questionnaire (Goldberg, 1972), Burnout questionnaire (Maclash and Jackson, 1993) and society support (Zimet, Dahlem, Zimet & Farley, 1988). Data were analyzed by Pearson correlation and multiple regression. The result of this research showed that variables such as social support, job satisfaction, organization commitment and general health had negative and significant relationship with Burnout (p<0.01), and negatively able to predict burnout (p<0.05).