The main goal of this research was modeling sustainable human resources development in effects of knowledge management channels and Organizational factors. Method of this research was descriptive with analysis of correlation and structural equation model. The statistical population included all employees of Islamic Azad University of Hormozgan province, that 228 people were selected as statistical sample of the research by Cochran formula. Measurement’ s instruments are three kinds of questioner on human resource development, Organizational factors and knowledge management process, which their reliability are calculated by Cronbach’ s alpha method and are reported as, in order, 0. 91. 0. 98, 0. 93. Validity of questioners is based on Confirmatory Factor Analysis that indicated good validity of structure. Data are analyzed by SPSS 20 and Liseral8. 54 software. Results indicated that Organizational factors had a positive, direct and meaningful effect on knowledge management process. Knowledge management process had a positive, direct and meaningful effect on human resource development. Organizational factors had a positive, direct and meaningful effect on human resource development., Organizational factors had a positive, indirect and meaningful effect on human resource development with mediator of knowledge management process. So, resulted experimental model is in accordance with conceptual model of research. General conclusion of this research was existence of relation between Organizational factors and human resource development with role of mediator of knowledge management among staff of Islamic Azad University of Hormozgan.