To evaluate the effect of salinity stress on the biochemical reactions of almond genotypes, a factorialexperiment was carried out based on completely randomized design (CRD), with two factors; genotypesin 4 levels (Shahrood 12, ‘ Touno’ cultivars and ‘ 1-16’ genotype budded on GF677 rootstock and GF677(without budding)) and irrigation water salinity in 3 levels (0, 1. 2, 2. 4, 3. 6, and 4. 8 g/L of natural saltequal to electrical conductivity of 0. 5, 2. 5, 4. 9, 7. 3 and 9. 8 ds/m respectively). Total phenolics, antioxidant capacity, soluble carbohydrate, non-soluble carbohydrate, proline, total soluble proteins, hydrogen peroxide, malondialdehyde, other aldehydes, enzymes activity of catalase, ghayacol peroxidaseand ascorbat peroxidase were measured at the end of experiment. Results showed that in all genotypeswith increasing salinity level (to 4. 8 gr/lit), the content of hydrogen peroxide, malondialdehyde and otheraldehydes were increased. Also, the content of total phenolics, antioxidant capacity, solublecarbohydrates, proline, total soluble proteins, enzymes activity of catalase, ghayacol peroxidase andascorbat peroxidase, were increased at the lower salinity levels (1. 2 and 2. 4 g/lit), but their contents werereduced in higher salinity levels. Thoroughly, the highest content of soluble proteins, enzymes activity ofcatalase, ghayacol peroxidase and ascorbat peroxidase at salinity level 3. 6 gr/lit and the highest content oftotal phenolics, antioxidant capacity, soluble carbohydrate and prolin at salinity level 4. 8 gr/lit wereobserved in ‘ Shahrood 12’ cultivar. Also, the lowest content of hydrogen peroxide, malondialdehyde, other aldehydes and total non-soluble carbohydrate at salinity levels 3. 6 and 4. 8 gr/lit were observed in‘ Shahrood 12’ cultivar. Finally, ’ Shahrood 12’ budded on GF677 rootstock was recognized as the mosttolerant cultivar to salinity.