The present study aims to design the competency model of managers of Iranian science and technology parks, as knowledge-based scientific and research institutions. This is a non-experimental research using a descriptive-analytical design with developmental objective, which was conducted through a mixed method. The study population includes three groups, namely managers, experts, and academics of the parks with managerial competencies. Qualitative sampling was done through snowball method, and a targeted random sampling was employed for quantitative part. Qualitative data was collected through desk study (of books and papers) and interview, a field study and a questionnaire inquiry were conducted for collection of quantitative data. The data was analyzed through descriptive statistics and inferential statistics, including exploratory factor analysis (EFA), confirmatory factor analysis (CFA), T test, and Chi-square test. In the first stage, 198 concept codes were obtained through the qualitative approach specifically content analysis with category systems (coding). Then, 84 indices were identified after categorizing the codes. These indices were formed under nine main components and in three dimensions, namely general competency, interpersonal competency, and professional competency. During the second stage, a questionnaire was made and its validity and reliability were measured. The reliability (Cronbach's alpha) for general, social, and professional competencies was 0. 899, 0. 875, and 0949 respectively. The results of EFA and CFA analyses showed that the competency of managers of science and technology parks included 74 indices, 19 components, and 3 dimensions. Four components for general competency included perception attitude, innovation, and personality. Seven components for interpersonal competency were team work, leadership, effective communication, participation and consultation, global thinking, networking, and strategic insight. Eight components for professional competency considered as IT management, investment management, financial management, marketing management strategic management, environmental management, monitoring and evaluation and executive management.