Introduction: Children, who grow up in family environments, are resilient to life problems.Therefore, this study was done to compare risky behavior, communication skills and self-efficacy between adolescents that have been raised in an orphanage, replacement families and normal families.Methods: Descriptive and causal-comparative analysis was used as a research method. The statistical population included all adolescents aged 12 to 18 years, living in an orphanage, replacement families and normal families of Bandar Abbas, during year 2015. The sample of this study was 150 adolescents, which were selected from 50 orphanage adolescents and 50 adolescents of replacement families by purposive sampling and 50 adolescents of normal families by random sampling. Iranian Adolescents Risk Scale, General Self-Efficacy Scale and Queendom Communication Skills Test were used for gathering the data. Multiple-way analysis of variance and SPSS software were used for analyzing the data.Results: Mean and standard deviation of risky behavior in adolescents of orphanages were 118.04 ± 5.85, and for replacement families and normal families, these were 110.14 ± 5.21 and 109.82 ±6.06, respectively. Mean and standard deviation of communication skills in adolescents of orphanages were 111.17 ± 6.19, for replacement families, this was 122.11 ± 7.62 and for normal families it was 121.03 ± 6.42. Self-efficacy values in adolescents of orphanages were 53.33 ± 3.84, replacement families 61.39 ± 4.01 and normal families 63.20 ± 3.26. There was no significant difference between adolescents of normal families and replacement families in risky behaviors, communication skills and self-efficacy (P>0.05), yet there was a significant difference between adolescents of normal families and replacement families with orphanage adolescences in risky behaviors, communication skills and self-efficacy (P<0.05).Conclusions: The occurrence of risky behaviors is high in orphan adolescents. Also, orphan adolescents have weak communication skills and their perception of self-efficacy is low. Therefore, it is important to develop programs and conduct training to prevent risky behaviors as well as increase communication skills and self-efficacy in adolescents of orphanage.